| Jupiter Topco LLC |
| 0.03% | — | #26 | $76.5M | 5.7M | $0 | 0 | +5.7M | New Buy |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.58% | 0.5% | #10 | $67.2M | 5.0M | $47.0M | 5.0M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #74 | $60.5M | 4.5M | $38.6M | 4.1M | +400,756+9.67% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #45 | $56.6M | 4.3M | $39.2M | 4.2M | +53,230+1.27% | Add |
| Novo Holdings A/S |
| 2.52% | 2.75% | #3 | $43.2M | 3.2M | $34.0M | 3.7M | -401,559-11.00% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #71 | $38.7M | 2.9M | $25.2M | 2.7M | +203,234+7.51% | Add |
| BVF INC/IL |
| 0.98% | 0.85% | #7 | $38.3M | 2.9M | $26.8M | 2.9M | 00.00% | Unchanged |
| T. Rowe Price Investment Management, Inc. |
| 0.02% | — | #31 | $33.4M | 2.5M | $0 | 0 | +2.5M | New Buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.04% | 0.02% | #25 | $29.9M | 2.2M | $14.9M | 1.6M | +644,047+40.12% | Add |
| Trails Edge Capital Partners, LP |
| 4.7% | 2.78% | #2 | $29.6M | 2.2M | $12.1M | 1.3M | +925,000+70.99% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #89 | $27.9M | 2.1M | $0 | 0 | +2.1M | New Buy |
| ARMISTICE CAPITAL, LLC |
| 0.33% | 0.33% | #12 | $26.6M | 2.0M | $18.6M | 2.0M | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #79 | $15.0M | 1.1M | $9.9M | 1.1M | +63,121+5.92% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #72 | $14.9M | 1.1M | $9.1M | 974,173 | +146,501+15.04% | Add |
| Evergreen Quality Fund GP, Ltd. |
| 0.2% | 0.2% | #18 | $12.7M | 951,474 | $8.9M | 951,474 | 00.00% | Unchanged |
| Parkman Healthcare Partners LLC |
| 1.29% | 0.5% | #5 | $12.6M | 948,184 | $4.9M | 522,577 | +425,607+81.44% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #68 | $12.0M | 901,197 | $3.0M | 317,096 | +584,101+184.20% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #59 | $9.7M | 730,857 | $4.9M | 522,823 | +208,034+39.79% | Add |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #53 | $9.5M | 710,942 | $6.6M | 708,044 | +2,898+0.41% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #38 | $8.2M | 614,573 | $5.4M | 578,265 | +36,308+6.28% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #102 | $7.7M | 579,903 | $0 | 0 | +579,903 | New Buy |
| DIADEMA PARTNERS LP |
| 0.94% | — | #8 | $7.6M | 571,107 | $0 | 0 | +571,107 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #76 | $7.5M | 562,929 | $3.2M | 342,034 | +220,895+64.58% | Add |
| ACUTA CAPITAL PARTNERS, LLC |
| 4.71% | — | #1 | $6.8M | 507,801 | $0 | 0 | +507,801 | New Buy |
| Nuveen, LLC |
| <0.01% | <0.01% | #61 | $6.7M | 503,071 | $5.2M | 561,805 | -58,734-10.45% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #101 | $6.7M | 503,020 | $7.3M | 835,911 | -332,891-39.82% | Reduce |
| RTW INVESTMENTS, LP |
| 0.05% | 0.04% | #24 | $6.3M | 475,737 | $4.4M | 475,737 | 00.00% | Unchanged |
| Catalio Capital Management, LP |
| 1.18% | — | #6 | $6.3M | 471,254 | $0 | 0 | +471,254 | New Buy |
| Schonfeld Strategic Advisors LLC |
| 0.02% | 0.01% | #33 | $5.4M | 407,470 | $941,332 | 101,110 | +306,360+303.00% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #107 | $5.2M | 402,137 | $3.6M | 415,655 | -13,518-3.25% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #86 | $4.5M | 339,275 | $3.1M | 328,379 | +10,896+3.32% | Add |
| Opaleye Management Inc. |
| 0.4% | 0.14% | #11 | $4.4M | 334,437 | $1.0M | 112,291 | +222,146+197.83% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #78 | $3.7M | 276,238 | $0 | 0 | +276,238 | New Buy |
| Burkehill Global Management, LP |
| 0.13% | 0.13% | #19 | $3.7M | 275,000 | $2.6M | 275,000 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #95 | $3.4M | 256,673 | $1.5M | 158,120 | +98,553+62.33% | Add |
| Propel Bio Management, LLC |
| 1.76% | 2.26% | #4 | $3.4M | 252,654 | $3.6M | 380,420 | -127,766-33.59% | Reduce |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #75 | $3.2M | 242,349 | $2.5M | 266,147 | -23,798-8.94% | Reduce |
| FEDERATED HERMES, INC. |
| <0.01% | 0.02% | #47 | $3.0M | 222,416 | $13.3M | 1.4M | -1.2M-84.47% | Reduce |
| ArrowMark Colorado Holdings LLC |
| 0.11% | 0.05% | #22 | $2.7M | 202,864 | $1.9M | 202,864 | 00.00% | Unchanged |
| Woodline Partners LP |
| 0.01% | 0.01% | #41 | $2.7M | 200,001 | $1.9M | 200,001 | 00.00% | Unchanged |
| Brevan Howard Capital Management LP |
| 0.01% | — | #34 | $2.4M | 176,850 | $0 | 0 | +176,850 | New Buy |
| Greenland Capital Management LP |
| 0.28% | — | #15 | $2.3M | 172,257 | $0 | 0 | +172,257 | New Buy |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #55 | $2.2M | 163,545 | $186,000 | 20,109 | +143,436+713.29% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #104 | $2.0M | 152,337 | $1.2M | 133,607 | +18,730+14.02% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #125 | $2.0M | 150,382 | $2.9M | 310,684 | -160,302-51.60% | Reduce |
| Perigon Wealth Management, LLC |
| 0.03% | 0.02% | #28 | $1.9M | 146,185 | $1.4M | 146,197 | -12-0.01% | Reduce |
| Persistent Asset Partners Ltd |
| 0.59% | — | #9 | $1.9M | 145,585 | $0 | 0 | +145,585 | New Buy |
| VOYA INVESTMENT MANAGEMENT LLC |
| <0.01% | <0.01% | #60 | $1.9M | 140,200 | $422,293 | 45,359 | +94,841+209.09% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #126 | $1.8M | 134,561 | $1.9M | 208,028 | -73,467-35.32% | Reduce |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #106 | $1.7M | 128,464 | $1.0M | 108,872 | +19,592+18.00% | Add |
