| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | 0.01% | #56 | $214.4M | 8.9M | $110.5M | 6.7M | +2.1M+31.86% | Add |
| NEA Management Company, LLC |
| 11.72% | 7.19% | #2 | $186.2M | 7.7M | $126.5M | 7.7M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #101 | $165.6M | 6.8M | $92.7M | 5.6M | +1.2M+21.38% | Add |
| TCG Crossover Management, LLC |
| 2.69% | 2.18% | #7 | $111.9M | 4.6M | $76.0M | 4.6M | 00.00% | Unchanged |
| Vestal Point Capital, LP |
| 2.6% | 1.66% | #8 | $111.3M | 4.6M | $59.3M | 3.6M | +996,535+27.65% | Add |
| BVF INC/IL |
| 2.76% | 2.34% | #6 | $108.0M | 4.5M | $73.4M | 4.5M | 00.00% | Unchanged |
| BAKER BROS. ADVISORS LP |
| 0.53% | 0.41% | #20 | $105.2M | 4.3M | $71.5M | 4.3M | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #95 | $90.3M | 3.7M | $55.2M | 3.4M | +377,436+11.25% | Add |
| MONTANOVA CAPITAL, LLC |
| 1.57% | 1.78% | #13 | $85.9M | 3.5M | $69.5M | 4.2M | -677,270-16.02% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #113 | $82.6M | 3.4M | $51.0M | 3.1M | +312,682+10.09% | Add |
| Versant Venture Management, LLC |
| 47.34% | 37% | #1 | $77.0M | 3.2M | $52.3M | 3.2M | 00.00% | Unchanged |
| BRAIDWELL LP |
| 2.19% | 1.76% | #9 | $59.3M | 2.5M | $52.7M | 3.2M | -755,012-23.55% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #102 | $45.1M | 1.9M | $25.4M | 1.5M | +323,301+20.98% | Add |
| AMERICAN CENTURY COMPANIES INC |
| 0.02% | 0.02% | #61 | $39.3M | 1.6M | $46.2M | 2.8M | -1.2M-42.24% | Reduce |
| MARSHALL WACE, LLP |
| 0.03% | 0.02% | #52 | $38.6M | 1.6M | $23.6M | 1.4M | +160,448+11.20% | Add |
| Aisling Capital Management LP |
| 7.98% | 5.37% | #3 | $37.6M | 1.6M | $25.6M | 1.6M | 00.00% | Unchanged |
| Bellevue Group AG |
| 0.61% | 0.49% | #17 | $28.8M | 1.2M | $20.6M | 1.3M | -60,000-4.80% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| 0.01% | <0.01% | #78 | $28.5M | 1.2M | $17.1M | 1.0M | +136,116+13.07% | Add |
| MPM BioImpact LLC |
| 1.71% | 1.5% | #11 | $28.1M | 1.2M | $19.4M | 1.2M | -15,847-1.35% | Reduce |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 2.79% | 3.36% | #5 | $26.8M | 1.1M | $32.9M | 2.0M | -893,745-44.64% | Reduce |
| Jupiter Topco LLC |
| 0.01% | — | #68 | $26.0M | 1.1M | $0 | 0 | +1.1M | New Buy |
| Frazier Life Sciences Management, L.P. |
| 0.53% | 0.42% | #21 | $24.2M | 1.0M | $16.5M | 1.0M | 00.00% | Unchanged |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #107 | $24.2M | 998,253 | $16.5M | 1.0M | -3,274-0.33% | Reduce |
| Woodline Partners LP |
| 0.07% | <0.01% | #39 | $23.3M | 962,884 | $1.2M | 74,496 | +888,388+1,192.53% | Add |
| FMR LLC |
| <0.01% | <0.01% | #129 | $22.6M | 934,414 | $16.8M | 1.0M | -89,890-8.78% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #133 | $19.2M | 791,932 | $8.5M | 515,966 | +275,966+53.49% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #127 | $19.1M | 789,545 | $4.8M | 645,196 | +144,349+22.37% | Add |
| Nextech Invest Ltd. |
| 0.88% | 0.35% | #14 | $18.4M | 761,153 | $5.0M | 304,237 | +456,916+150.18% | Add |
| Opaleye Management Inc. |
| 1.63% | — | #12 | $18.0M | 745,000 | $0 | 0 | +745,000 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #112 | $15.8M | 652,087 | $13.6M | 826,624 | -174,537-21.11% | Reduce |
| Nantahala Capital Management, LLC |
| 0.53% | 0.39% | #22 | $15.8M | 651,993 | $10.7M | 651,993 | 00.00% | Unchanged |
| FIRST TRUST ADVISORS LP |
| 0.01% | — | #71 | $15.7M | 647,796 | $0 | 0 | +647,796 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #108 | $14.9M | 616,310 | $9.0M | 546,689 | +69,621+12.74% | Add |
| BOONE CAPITAL MANAGEMENT LLC |
| 3.48% | — | #4 | $14.9M | 615,287 | $0 | 0 | +615,287 | New Buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.24% | 0.17% | #29 | $13.4M | 552,566 | $8.7M | 528,698 | +23,868+4.51% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #82 | $12.6M | 520,648 | $10.8M | 658,483 | -137,835-20.93% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #94 | $12.2M | 505,500 | $6.7M | 407,078 | +98,422+24.18% | Add |
| Parkwood LLC |
| 0.87% | 0.74% | #15 | $12.2M | 505,000 | $8.3M | 505,000 | 00.00% | Unchanged |
| Alphabet Inc. |
| 0.26% | 0.28% | #25 | $11.3M | 684,275 | $11.3M | 684,275 | 00.00% | Unchanged |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | 0.01% | #64 | $10.9M | 450,000 | $4.1M | 250,000 | +200,000+80.00% | Add |
| Caption Management, LLC |
| 0.05% | — | #44 | $10.0M | 412,322 | $0 | 0 | +412,322 | New Buy |
| KENNEDY CAPITAL MANAGEMENT LLC |
| 0.17% | 0.01% | #32 | $9.8M | 405,529 | $526,022 | 31,977 | +373,552+1,168.19% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #111 | $9.3M | 383,335 | $592,151 | 35,997 | +347,338+964.91% | Add |
| Fisher Asset Management, LLC |
| <0.01% | <0.01% | #97 | $8.8M | 363,520 | $5.2M | 314,862 | +48,658+15.45% | Add |
| Allspring Global Investments Holdings, LLC |
| 0.01% | 0.01% | #65 | $8.5M | 352,857 | $6.5M | 392,227 | -39,370-10.04% | Reduce |
| Empowered Funds, LLC |
| 0.04% | 0.03% | #47 | $8.0M | 329,266 | $5.0M | 305,398 | +23,868+7.82% | Add |
| Duquesne Family Office LLC |
| 0.14% | — | #33 | $7.2M | 297,600 | $0 | 0 | +297,600 | New Buy |
| TD ASSET MANAGEMENT INC |
| 0.01% | <0.01% | #77 | $6.9M | 285,936 | $4.7M | 286,978 | -1,042-0.36% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #153 | $6.2M | 254,561 | $6.4M | 387,542 | -132,981-34.31% | Reduce |
| DIADEMA PARTNERS LP |
| 0.74% | 0.52% | #16 | $6.0M | 248,491 | $3.1M | 187,307 | +61,184+32.67% | Add |
