| ORBIMED ADVISORS LLC |
| 2.02% | 2.08% | #5 | $107.0M | 7.2M | $104.8M | 7.2M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #87 | $106.7M | 7.1M | $90.1M | 6.2M | +978,389+15.88% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #80 | $66.8M | 4.5M | $52.2M | 3.6M | +908,099+25.47% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | <0.01% | #64 | $56.6M | 3.8M | $42.7M | 2.9M | +871,826+29.88% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #97 | $49.2M | 3.3M | $47.3M | 3.2M | +58,172+1.80% | Add |
| ADAMS STREET PARTNERS LLC |
| 11.06% | 18.41% | #1 | $48.9M | 3.3M | $47.9M | 3.3M | 00.00% | Unchanged |
| Vivo Capital, LLC |
| 3.83% | 3.41% | #3 | $41.9M | 2.8M | $41.0M | 2.8M | 00.00% | Unchanged |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.01% | 0.01% | #60 | $40.8M | 2.7M | $33.9M | 2.3M | +413,115+17.82% | Add |
| PERCEPTIVE ADVISORS LLC |
| 0.6% | 0.66% | #13 | $39.9M | 2.7M | $33.5M | 2.3M | +375,000+16.36% | Add |
| Deep Track Capital, LP |
| 0.54% | 0.6% | #16 | $37.2M | 2.5M | $36.5M | 2.5M | +400+0.02% | Add |
| BRAIDWELL LP |
| 1.18% | 0.86% | #9 | $31.8M | 2.1M | $25.6M | 1.8M | +373,500+21.31% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #88 | $27.7M | 1.9M | $25.1M | 1.7M | +140,918+8.23% | Add |
| Foresite Capital Management VI LLC |
| 4.26% | 5.82% | #2 | $27.4M | 1.8M | $26.8M | 1.8M | 00.00% | Unchanged |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #78 | $23.6M | 1.6M | $22.5M | 1.5M | +35,543+2.31% | Add |
| Hood River Capital Management LLC |
| 0.17% | 0.2% | #26 | $23.5M | 1.6M | $19.5M | 1.3M | +236,696+17.73% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #96 | $20.1M | 1.3M | $4.5M | 617,224 | +727,512+117.87% | Add |
| Boxer Capital Management, LLC |
| 1.24% | 2.11% | #8 | $16.4M | 1.1M | $16.1M | 1.1M | 00.00% | Unchanged |
| Catalio Capital Management, LP |
| 3.03% | 2.73% | #4 | $16.1M | 1.1M | $13.0M | 891,933 | +188,955+21.18% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #91 | $15.7M | 1.1M | $11.2M | 768,436 | +281,705+36.66% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #65 | $15.7M | 1.0M | $12.7M | 866,362 | +181,623+20.96% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #83 | $15.6M | 1.0M | $13.4M | 912,722 | +130,129+14.26% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #122 | $12.2M | 814,750 | $9.8M | 669,895 | +144,855+21.62% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.01% | #57 | $11.7M | 785,208 | $7.9M | 539,869 | +245,339+45.44% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #114 | $11.3M | 757,798 | $3.5M | 237,004 | +520,794+219.74% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | 0.02% | #52 | $11.2M | 750,000 | $11.0M | 750,000 | 00.00% | Unchanged |
| Eversept Partners, LP |
| 0.58% | — | #14 | $11.2M | 747,994 | $0 | 0 | +747,994 | New Buy |
| EMERALD ADVISERS, LLC |
| 0.24% | 0.32% | #22 | $10.2M | 685,683 | $10.0M | 686,216 | -533-0.08% | Reduce |
| DCF Advisers, LLC |
| 1.68% | 2.49% | #6 | $9.5M | 637,500 | $9.3M | 637,500 | 00.00% | Unchanged |
| Blue Owl Capital Holdings LP |
| 1.32% | 2.14% | #7 | $9.1M | 608,600 | $8.0M | 545,000 | +63,600+11.67% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #100 | $8.6M | 575,158 | $7.4M | 506,104 | +69,054+13.64% | Add |
| EMERALD MUTUAL FUND ADVISERS TRUST |
| 0.28% | 0.33% | #20 | $7.9M | 526,389 | $6.7M | 459,253 | +67,136+14.62% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #85 | $7.8M | 520,528 | $7.4M | 504,631 | +15,897+3.15% | Add |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.06% | 0.07% | #36 | $6.7M | 450,000 | $6.6M | 450,000 | 00.00% | Unchanged |
| Nextech Invest Ltd. |
| 0.32% | 0.46% | #19 | $6.7M | 450,000 | $6.6M | 450,000 | 00.00% | Unchanged |
| DIADEMA PARTNERS LP |
| 0.79% | 0.87% | #10 | $6.4M | 428,211 | $5.1M | 351,111 | +77,100+21.96% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #111 | $5.9M | 396,116 | $4.2M | 289,114 | +107,002+37.01% | Add |
| Caption Management, LLC |
| 0.03% | 0.01% | #44 | $5.5M | 365,434 | $2.3M | 160,000 | +205,434+128.40% | Add |
| BARCLAYS PLC |
| <0.01% | <0.01% | #107 | $4.7M | 315,749 | $3.6M | 243,776 | +71,973+29.52% | Add |
| Jump Financial, LLC |
| 0.04% | 0.03% | #39 | $4.7M | 313,400 | $2.2M | 147,850 | +165,550+111.97% | Add |
| Trexquant Investment LP |
| 0.03% | — | #43 | $4.4M | 296,347 | $0 | 0 | +296,347 | New Buy |
| Polymer Capital Management (HK) LTD |
| 0.2% | 0.23% | #24 | $3.9M | 263,662 | $2.7M | 183,187 | +80,475+43.93% | Add |
| Brevan Howard Capital Management LP |
| 0.02% | 0.02% | #46 | $3.7M | 250,291 | $2.5M | 167,971 | +82,320+49.01% | Add |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.48% | 0.58% | #17 | $3.7M | 244,961 | $3.6M | 247,961 | -3,000-1.21% | Reduce |
| Spruce Street Capital LP |
| 0.68% | 0.81% | #11 | $3.5M | 231,585 | $3.4M | 231,585 | 00.00% | Unchanged |
| SEB Asset Management AB |
| 0.01% | 0.01% | #55 | $3.4M | 226,837 | $3.3M | 226,837 | 00.00% | Unchanged |
| VICTORY CAPITAL MANAGEMENT INC |
| <0.01% | <0.01% | #82 | $3.3M | 220,761 | $1.9M | 128,352 | +92,409+72.00% | Add |
| Connor, Clark & Lunn Investment Management Ltd. |
| 0.01% | <0.01% | #62 | $3.3M | 217,750 | $1.2M | 83,907 | +133,843+159.51% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #128 | $3.1M | 208,119 | $2.8M | 188,129 | +19,990+10.63% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #123 | $3.0M | 202,609 | $2.7M | 185,347 | +17,262+9.31% | Add |
| F/m Investments LLC |
| 0.13% | 0.1% | #29 | $2.5M | 167,165 | $1.5M | 100,029 | +67,136+67.12% | Add |
