| MORGAN STANLEY |
| 0.01% | <0.01% | #56 | $123.9M | 1.3M | $14.9M | 442,856 | +865,195+195.37% | Add |
| PERCEPTIVE ADVISORS LLC |
| 1.85% | 1.9% | #5 | $123.0M | 1.3M | $97.0M | 1.4M | -144,944-10.05% | Reduce |
| Sanofi |
| 20.54% | 23.17% | #1 | $109.7M | 1.2M | $77.8M | 1.2M | 00.00% | Unchanged |
| VIKING GLOBAL INVESTORS LP |
| 0.3% | 0.27% | #12 | $106.5M | 1.1M | $96.7M | 1.4M | -313,776-21.82% | Reduce |
| HighTower Advisors, LLC |
| 0.08% | 0.06% | #28 | $82.5M | 870,551 | $58.5M | 870,200 | +351+0.04% | Add |
| BANK OF AMERICA CORP /DE/ |
| 0.01% | <0.01% | #58 | $79.7M | 841,141 | $2.2M | 32,683 | +808,458+2,473.63% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #88 | $78.3M | 825,972 | $53.7M | 798,898 | +27,074+3.39% | Add |
| Schonfeld Strategic Advisors LLC |
| 0.23% | 0.12% | #15 | $66.1M | 697,586 | $17.1M | 254,827 | +442,759+173.75% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #80 | $60.7M | 640,458 | $37.0M | 550,845 | +89,613+16.27% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #91 | $46.7M | 492,477 | $32.7M | 486,422 | +6,055+1.24% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #63 | $38.3M | 404,676 | $10.9M | 161,574 | +243,102+150.46% | Add |
| Woodline Partners LP |
| 0.12% | 0.1% | #21 | $38.0M | 400,892 | $25.8M | 384,433 | +16,459+4.28% | Add |
| Capital Research Global Investors |
| <0.01% | <0.01% | #59 | $34.4M | 363,050 | $26.4M | 392,847 | -29,797-7.58% | Reduce |
| PFM Health Sciences, LP |
| 2.51% | 1.87% | #3 | $29.2M | 308,385 | $20.5M | 305,431 | +2,954+0.97% | Add |
| Sofinnova Investments, Inc. |
| 1.48% | 1.04% | #9 | $28.7M | 303,103 | $27.3M | 406,029 | -102,926-25.35% | Reduce |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND |
| 0.04% | 0.02% | #35 | $25.7M | 271,700 | $11.5M | 170,700 | +101,000+59.17% | Add |
| Parkman Healthcare Partners LLC |
| 2.49% | — | #4 | $24.3M | 256,950 | $0 | 0 | +256,950 | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #86 | $24.3M | 256,175 | $15.6M | 231,509 | +24,666+10.65% | Add |
| CDC Financial, Inc. |
| 6.75% | 7.97% | #2 | $16.1M | 170,130 | $12.5M | 186,530 | -16,400-8.79% | Reduce |
| First Turn Management, LLC |
| 1.67% | — | #6 | $15.6M | 164,783 | $0 | 0 | +164,783 | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #60 | $13.9M | 147,200 | $22.0M | 327,860 | -180,660-55.10% | Reduce |
| FIRST TRUST ADVISORS LP |
| 0.01% | — | #54 | $12.2M | 128,424 | $0 | 0 | +128,424 | New Buy |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #108 | $11.6M | 122,557 | $4.9M | 72,460 | +50,097+69.14% | Add |
| CAPITOLIS LIQUID GLOBAL MARKETS LLC |
| 0.05% | 0.05% | #31 | $11.3M | 119,200 | $8.4M | 125,000 | -5,800-4.64% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #96 | $9.7M | 102,372 | $10.6M | 157,373 | -55,001-34.95% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #89 | $9.6M | 100,957 | $6.3M | 93,696 | +7,261+7.75% | Add |
| NORGES BANK |
| <0.01% | — | #93 | $8.6M | 90,300 | $0 | 0 | +90,300 | New Buy |
| CITIGROUP INC |
| <0.01% | <0.01% | #70 | $7.2M | 75,721 | $4.2M | 62,516 | +13,205+21.12% | Add |
| Jefferies Financial Group Inc. |
| 0.05% | 0.02% | #32 | $7.0M | 73,416 | $2.6M | 38,973 | +34,443+88.38% | Add |
| NOMURA HOLDINGS INC |
| 0.01% | <0.01% | #50 | $7.0M | 73,400 | $1.0M | 15,500 | +57,900+373.55% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #84 | $6.6M | 69,920 | $4.3M | 64,322 | +5,598+8.70% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #52 | $5.9M | 62,201 | $3.4M | 50,183 | +12,018+23.95% | Add |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 0.08% | — | #30 | $5.8M | 61,545 | $0 | 0 | +61,545 | New Buy |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #66 | $5.7M | 59,841 | $2.2M | 32,539 | +27,302+83.91% | Add |
| Voleon Capital Management LP |
| 0.1% | 0.06% | #23 | $5.5M | 58,358 | $2.6M | 39,305 | +19,053+48.47% | Add |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
| 0.02% | <0.01% | #42 | $4.6M | 48,765 | $907,672 | 13,501 | +35,264+261.20% | Add |
| Western Standard LLC |
| 1.51% | — | #8 | $4.5M | 47,000 | $0 | 0 | +47,000 | New Buy |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #74 | $4.3M | 45,022 | $6.7M | 100,137 | -55,115-55.04% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #112 | $4.0M | 42,700 | $4.8M | 71,157 | -28,457-39.99% | Reduce |
| Caption Management, LLC |
| 0.02% | 0.01% | #43 | $3.8M | 40,400 | $1.2M | 17,600 | +22,800+129.55% | Add |
| VICTORY CAPITAL MANAGEMENT INC |
| <0.01% | <0.01% | #76 | $3.5M | 36,443 | $734,421 | 10,924 | +25,519+233.60% | Add |
| ArrowMark Colorado Holdings LLC |
| 0.14% | 0.06% | #20 | $3.3M | 35,176 | $2.4M | 35,176 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #114 | $3.3M | 35,019 | $3.2M | 48,137 | -13,118-27.25% | Reduce |
| HUSSMAN STRATEGIC ADVISORS, INC. |
| 0.69% | — | #10 | $3.0M | 31,500 | $0 | 0 | +31,500 | New Buy |
| Empyrean Capital Partners, LP |
| 0.09% | — | #25 | $2.8M | 30,000 | $0 | 0 | +30,000 | New Buy |
| Atom Investors LP |
| 0.25% | 0.13% | #14 | $2.8M | 29,594 | $1.8M | 26,505 | +3,089+11.65% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #119 | $2.7M | 28,678 | $1.7M | 25,671 | +3,007+11.71% | Add |
| Corient Private Wealth LLC |
| <0.01% | <0.01% | #73 | $2.7M | 28,653 | $1.9M | 28,814 | -161-0.56% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #116 | $2.5M | 26,200 | $1.7M | 25,874 | +326+1.26% | Add |
| Point72 Asset Management, L.P. |
| <0.01% | — | #65 | $2.5M | 26,011 | $0 | 0 | +26,011 | New Buy |
