| BlackRock, Inc. |
| <0.01% | <0.01% | #97 | $212.8M | 8.8M | $138.3M | 8.9M | -155,293-1.74% | Reduce |
| Vestal Point Capital, LP |
| 4.56% | 2.82% | #3 | $195.3M | 8.1M | $100.8M | 6.5M | +1.6M+23.85% | Add |
| Deep Track Capital, LP |
| 2.73% | 1.61% | #5 | $187.7M | 7.7M | $98.4M | 6.3M | +1.4M+21.93% | Add |
| Rubric Capital Management LP |
| 1.61% | 0.41% | #8 | $175.3M | 7.2M | $38.3M | 2.5M | +4.8M+192.16% | Add |
| FMR LLC |
| 0.01% | <0.01% | #74 | $133.1M | 5.5M | $85.9M | 5.5M | -56,056-1.01% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.01% | #62 | $131.9M | 5.4M | $51.0M | 3.3M | +2.1M+65.23% | Add |
| MORGAN STANLEY |
| 0.01% | <0.01% | #73 | $115.5M | 4.8M | $20.9M | 2.3M | +2.5M+110.66% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #93 | $113.5M | 4.7M | $79.7M | 5.1M | -463,951-9.02% | Reduce |
| BAKER BROS. ADVISORS LP |
| 0.57% | 0.41% | #21 | $113.0M | 4.7M | $72.2M | 4.7M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #106 | $109.1M | 4.5M | $68.6M | 4.4M | +68,417+1.55% | Add |
| PERCEPTIVE ADVISORS LLC |
| 1.57% | 1.12% | #10 | $104.8M | 4.3M | $57.5M | 3.7M | +609,545+16.43% | Add |
| Redmile Group, LLC |
| 6.64% | 7.94% | #1 | $98.8M | 4.1M | $119.9M | 7.7M | -3.7M-47.32% | Reduce |
| GENERAL ATLANTIC, L.P. |
| 2.53% | 2.96% | #6 | $73.6M | 3.0M | $63.6M | 4.1M | -1.1M-26.08% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #95 | $61.6M | 2.5M | $39.1M | 2.5M | +17,062+0.68% | Add |
| Pictet Asset Management Holding SA |
| 0.05% | 0.04% | #46 | $57.0M | 2.4M | $42.3M | 2.7M | -374,906-13.75% | Reduce |
| ARK Investment Management LLC |
| 0.28% | 0.21% | #33 | $43.5M | 1.8M | $26.7M | 1.7M | +72,061+4.19% | Add |
| Capital World Investors |
| 0.01% | <0.01% | #79 | $43.4M | 1.8M | $13.8M | 893,327 | +894,589+100.14% | Add |
| Trails Edge Capital Partners, LP |
| 6.06% | 6.19% | #2 | $38.2M | 1.6M | $27.0M | 1.7M | -170,000-9.75% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #83 | $37.1M | 1.5M | $21.4M | 1.4M | +149,119+10.80% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #116 | $36.0M | 1.5M | $17.1M | 1.1M | +380,595+34.53% | Add |
| Soleus Capital Management, L.P. |
| 1.22% | 0.59% | #12 | $35.5M | 1.5M | $14.5M | 938,163 | +527,000+56.17% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| 0.01% | <0.01% | #70 | $34.7M | 1.4M | $12.1M | 780,696 | +650,621+83.34% | Add |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 0.42% | 0.33% | #24 | $31.5M | 1.3M | $20.1M | 1.3M | 00.00% | Unchanged |
| BRAIDWELL LP |
| 1.15% | 0.91% | #13 | $31.2M | 1.3M | $27.1M | 1.8M | -463,997-26.50% | Reduce |
| Kynam Capital Management, LP |
| 1.6% | 1.14% | #9 | $29.0M | 1.2M | $18.5M | 1.2M | 00.00% | Unchanged |
| Woodline Partners LP |
| 0.08% | 0.05% | #42 | $25.8M | 1.1M | $14.3M | 925,444 | +138,562+14.97% | Add |
| Sumitomo Mitsui Trust Group, Inc. |
| 0.01% | 0.01% | #61 | $23.9M | 983,462 | $18.3M | 1.2M | -197,684-16.74% | Reduce |
| Amova Asset Management Americas, Inc. |
| 0.31% | 0.26% | #32 | $23.8M | 983,462 | $18.3M | 1.2M | -197,684-16.74% | Reduce |
| Affinity Asset Advisors, LLC |
| 1.06% | 0.77% | #16 | $23.5M | 967,620 | $15.0M | 967,620 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #100 | $22.2M | 917,117 | $15.1M | 976,362 | -59,245-6.07% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #104 | $21.3M | 876,070 | $13.2M | 854,466 | +21,604+2.53% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #127 | $20.4M | 842,089 | $12.4M | 802,153 | +39,936+4.98% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #101 | $20.2M | 833,296 | $14.3M | 924,039 | -90,743-9.82% | Reduce |
| Nuveen, LLC |
| <0.01% | <0.01% | #81 | $20.0M | 825,833 | $12.6M | 812,601 | +13,232+1.63% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #114 | $19.7M | 813,589 | $20.4M | 1.3M | -505,070-38.30% | Reduce |
| KENNEDY CAPITAL MANAGEMENT LLC |
| 0.31% | 0.18% | #31 | $17.6M | 724,508 | $8.7M | 561,250 | +163,258+29.09% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #91 | $16.7M | 686,338 | $9.8M | 632,231 | +54,107+8.56% | Add |
| Rhenman & Partners Asset Management AB |
| 1.57% | 0.6% | #11 | $16.6M | 684,250 | $4.9M | 313,500 | +370,750+118.26% | Add |
| Handelsbanken Fonder AB |
| 0.04% | 0.03% | #50 | $15.4M | 633,000 | $8.5M | 547,000 | +86,000+15.72% | Add |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #88 | $14.4M | 593,262 | $5.2M | 353,733 | +239,529+67.71% | Add |
| Sofinnova Investments, Inc. |
| 0.66% | — | #19 | $12.7M | 524,098 | $0 | 0 | +524,098 | New Buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.01% | — | #78 | $11.6M | 477,141 | $0 | 0 | +477,141 | New Buy |
| Elmind Capital, LP |
| 2.8% | 2.02% | #4 | $11.2M | 460,000 | $7.1M | 460,000 | 00.00% | Unchanged |
| CITIGROUP INC |
| <0.01% | <0.01% | #98 | $9.4M | 389,384 | $7.4M | 477,410 | -88,026-18.44% | Reduce |
| Candriam S.C.A. |
| 0.04% | 0.05% | #51 | $9.2M | 377,902 | $10.1M | 534,259 | -156,357-29.27% | Reduce |
| Fisher Asset Management, LLC |
| <0.01% | <0.01% | #102 | $9.0M | 369,465 | $6.0M | 384,831 | -15,366-3.99% | Reduce |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.03% | 0.04% | #54 | $8.8M | 363,603 | $9.6M | 620,820 | -257,217-41.43% | Reduce |
| FIRST TRUST ADVISORS LP |
| 0.01% | — | #77 | $8.8M | 360,848 | $0 | 0 | +360,848 | New Buy |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #86 | $8.3M | 340,578 | $3.5M | 223,363 | +117,215+52.48% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #124 | $8.1M | 334,138 | $5.0M | 321,360 | +12,778+3.98% | Add |
