| FMR LLC |
| 0.01% | 0.01% | #40 | $241.3M | 9.5M | $177.6M | 9.1M | +424,701+4.68% | Add |
| SR ONE CAPITAL MANAGEMENT, LP |
| 12.31% | 10.76% | #3 | $127.9M | 5.0M | $98.5M | 5.0M | 00.00% | Unchanged |
| NEA Management Company, LLC |
| 6.43% | 4.47% | #4 | $102.1M | 4.0M | $78.7M | 4.0M | 00.00% | Unchanged |
| Enavate Sciences GP, LLC |
| 28.8% | 21.8% | #1 | $99.5M | 3.9M | $76.6M | 3.9M | 00.00% | Unchanged |
| FEDERATED HERMES, INC. |
| 0.11% | 0.1% | #20 | $79.1M | 3.1M | $61.1M | 3.1M | -10,226-0.33% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #70 | $68.2M | 2.7M | $39.8M | 2.0M | +648,677+31.84% | Add |
| Capital International Investors |
| 0.01% | 0.01% | #38 | $63.5M | 2.5M | $47.6M | 2.4M | +68,912+2.83% | Add |
| Polar Capital Holdings Plc |
| 0.14% | 0.18% | #18 | $61.2M | 2.4M | $49.8M | 2.5M | -135,672-5.32% | Reduce |
| Fairmount Funds Management LLC |
| 3.96% | 3.33% | #7 | $59.9M | 2.4M | $46.1M | 2.4M | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #64 | $52.2M | 2.1M | $28.8M | 1.5M | +584,177+39.71% | Add |
| NVP Associates, LLC |
| 14.22% | 20.4% | #2 | $46.7M | 1.8M | $35.9M | 1.8M | 00.00% | Unchanged |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.01% | <0.01% | #46 | $40.5M | 1.6M | $24.4M | 1.2M | +347,766+27.91% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #74 | $34.4M | 1.4M | $24.3M | 1.2M | +109,473+8.79% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #58 | $31.2M | 1.2M | $7.6M | 388,347 | +842,812+217.03% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #54 | $31.1M | 1.2M | $7.0M | 357,266 | +869,662+243.42% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #68 | $22.4M | 882,654 | $12.8M | 655,785 | +226,869+34.60% | Add |
| ALLIANCEBERNSTEIN L.P. |
| 0.01% | 0.01% | #45 | $21.6M | 1.1M | $32.6M | 897,321 | +206,067+22.96% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | <0.01% | #35 | $20.7M | 815,150 | $5.4M | 275,056 | +540,094+196.36% | Add |
| EcoR1 Capital, LLC |
| 0.97% | 0.66% | #10 | $20.0M | 789,500 | $15.4M | 789,500 | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | <0.01% | #48 | $16.8M | 660,470 | $9.3M | 476,818 | +183,652+38.52% | Add |
| Woodline Partners LP |
| 0.05% | 0.04% | #27 | $15.0M | 590,539 | $11.5M | 590,525 | +14+0.00% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.02% | #34 | $14.6M | 576,717 | $13.0M | 667,070 | -90,353-13.54% | Reduce |
| ArrowMark Colorado Holdings LLC |
| 0.61% | 0.34% | #15 | $14.6M | 573,318 | $12.9M | 658,909 | -85,591-12.99% | Reduce |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 1.34% | 2.27% | #8 | $12.9M | 509,789 | $22.2M | 1.1M | -626,146-55.12% | Reduce |
| Rock Springs Capital Management LP |
| 0.62% | 0.58% | #14 | $12.7M | 502,077 | $9.8M | 502,077 | 00.00% | Unchanged |
| Pivotal bioVenture Partners Investment Advisor LLC |
| 4.05% | 4.14% | #6 | $12.5M | 490,766 | $11.6M | 591,991 | -101,225-17.10% | Reduce |
| NEXTBio Capital Management LP |
| 4.98% | 3.87% | #5 | $10.8M | 426,736 | $8.3M | 426,736 | 00.00% | Unchanged |
| Vestal Point Capital, LP |
| 0.22% | 0.11% | #16 | $9.3M | 365,000 | $3.9M | 200,000 | +165,000+82.50% | Add |
| MARSHALL WACE, LLP |
| 0.01% | 0.01% | #47 | $8.2M | 323,442 | $9.8M | 501,928 | -178,486-35.56% | Reduce |
| JENNISON ASSOCIATES LLC |
| <0.01% | <0.01% | #49 | $8.0M | 314,049 | $4.9M | 250,000 | +64,049+25.62% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #94 | $7.7M | 304,870 | $4.9M | 251,410 | +53,460+21.26% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #69 | $7.7M | 302,085 | $4.4M | 224,402 | +77,683+34.62% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #71 | $7.1M | 281,140 | $3.8M | 194,640 | +86,500+44.44% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #79 | $6.9M | 271,163 | $7.5M | 381,461 | -110,298-28.91% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #65 | $6.5M | 254,623 | $3.5M | 179,388 | +75,235+41.94% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #86 | $6.2M | 245,100 | $5.2M | 266,005 | -20,905-7.86% | Reduce |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.77% | 0.67% | #13 | $5.9M | 230,834 | $4.2M | 214,334 | +16,500+7.70% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #77 | $5.8M | 226,680 | $2.5M | 127,670 | +99,010+77.55% | Add |
| iA Global Asset Management Inc. |
| 0.06% | 0.06% | #26 | $5.5M | 215,130 | $4.2M | 215,830 | -700-0.32% | Reduce |
| Walleye Capital LLC |
| 0.02% | 0.01% | #33 | $5.3M | 209,050 | $2.4M | 125,232 | +83,818+66.93% | Add |
| Sio Capital Management, LLC |
| 0.88% | 0.93% | #11 | $5.3M | 208,557 | $6.5M | 331,730 | -123,173-37.13% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #80 | $4.5M | 178,089 | $7.2M | 367,405 | -189,316-51.53% | Reduce |
| Voleon Capital Management LP |
| 0.08% | 0.01% | #25 | $4.2M | 167,145 | $578,915 | 29,612 | +137,533+464.45% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #61 | $3.8M | 151,086 | $195,480 | 9,999 | +141,087+1,411.01% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #110 | $3.4M | 134,979 | $2.0M | 88,733 | +46,246+52.12% | Add |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #53 | $3.2M | 125,185 | $838,187 | 42,874 | +82,311+191.98% | Add |
| BARCLAYS PLC |
| <0.01% | <0.01% | #81 | $2.9M | 115,965 | $578,875 | 29,610 | +86,355+291.64% | Add |
| SEVEN GRAND MANAGERS, LLC |
| 0.1% | 0.13% | #21 | $2.5M | 100,000 | $2.0M | 100,000 | 00.00% | Unchanged |
| Birchview Capital, LP |
| 1.07% | 0.78% | #9 | $2.4M | 93,601 | $1.4M | 70,000 | +23,601+33.72% | Add |
| Verition Fund Management LLC |
| <0.01% | — | #55 | $1.9M | 72,988 | $0 | 0 | +72,988 | New Buy |
