| RA CAPITAL MANAGEMENT, L.P. |
| 1.49% | 1.65% | #2 | $171.9M | 11.2M | $155.5M | 11.2M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #85 | $94.2M | 6.1M | $75.5M | 5.4M | +701,434+12.91% | Add |
| Prosight Management, LP |
| 10.07% | 8.09% | #1 | $58.4M | 3.8M | $49.3M | 3.6M | +254,481+7.17% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #87 | $46.2M | 3.0M | $34.2M | 2.5M | +540,882+21.95% | Add |
| FMR LLC |
| <0.01% | <0.01% | #81 | $37.1M | 2.4M | $35.2M | 2.5M | -122,899-4.85% | Reduce |
| FEDERATED HERMES, INC. |
| 0.05% | <0.01% | #27 | $36.1M | 2.4M | $753,380 | 54,200 | +2.3M+4,241.19% | Add |
| Point72 Asset Management, L.P. |
| 0.03% | 0.02% | #32 | $30.6M | 2.0M | $16.1M | 1.2M | +837,697+72.46% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #113 | $28.5M | 1.9M | $25.2M | 1.8M | +45,986+2.54% | Add |
| TCG Crossover Management, LLC |
| 0.66% | 0.71% | #7 | $27.5M | 1.8M | $24.9M | 1.8M | 00.00% | Unchanged |
| Alyeska Investment Group, L.P. |
| 0.07% | 0.06% | #25 | $25.3M | 1.6M | $22.3M | 1.6M | +46,051+2.88% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #60 | $23.2M | 1.5M | $22.2M | 1.6M | -90,290-5.65% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #99 | $20.4M | 1.3M | $17.9M | 1.3M | +40,454+3.14% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #72 | $19.4M | 1.3M | $6.2M | 444,577 | +820,260+184.50% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | <0.01% | #41 | $18.5M | 1.2M | $1.6M | 116,099 | +1.1M+939.85% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #97 | $18.5M | 1.2M | $15.9M | 1.1M | +57,426+5.01% | Add |
| ALGERT GLOBAL LLC |
| 0.2% | 0.09% | #13 | $17.1M | 1.1M | $6.2M | 443,397 | +667,492+150.54% | Add |
| D. E. Shaw & Co., Inc. |
| 0.01% | <0.01% | #50 | $16.8M | 1.1M | $1.4M | 98,395 | +998,114+1,014.40% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #89 | $14.6M | 952,675 | $8.4M | 602,013 | +350,662+58.25% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #100 | $14.0M | 910,460 | $11.1M | 801,646 | +108,814+13.57% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #109 | $12.9M | 836,966 | $12.1M | 495,635 | +341,331+68.87% | Add |
| Nantahala Capital Management, LLC |
| 0.41% | 0.41% | #9 | $12.4M | 809,914 | $11.3M | 809,914 | 00.00% | Unchanged |
| Qube Research & Technologies Ltd |
| 0.01% | <0.01% | #46 | $10.8M | 702,057 | $2.7M | 197,145 | +504,912+256.11% | Add |
| Squarepoint Ops LLC |
| 0.01% | 0.01% | #47 | $8.2M | 532,321 | $8.4M | 604,000 | -71,679-11.87% | Reduce |
| ORBIMED ADVISORS LLC |
| 0.15% | 0.27% | #17 | $8.1M | 524,700 | $13.7M | 983,600 | -458,900-46.66% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #70 | $7.7M | 504,544 | $5.4M | 386,810 | +117,734+30.44% | Add |
| HRT FINANCIAL LP |
| 0.01% | 0.01% | #40 | $7.5M | 491,001 | $5.1M | 366,699 | +124,302+33.90% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #115 | $7.2M | 467,891 | $4.3M | 309,540 | +158,351+51.16% | Add |
| ADAR1 Capital Management, LLC |
| 0.3% | 0.24% | #11 | $6.5M | 420,881 | $4.1M | 298,546 | +122,335+40.98% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #107 | $6.1M | 398,366 | $5.0M | 362,180 | +36,186+9.99% | Add |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. |
| 0.32% | 0.44% | #10 | $5.8M | 376,496 | $5.2M | 376,496 | 00.00% | Unchanged |
| Woodline Partners LP |
| 0.02% | 0.04% | #35 | $5.7M | 370,032 | $10.3M | 738,032 | -368,000-49.86% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #104 | $5.7M | 369,191 | $4.9M | 354,328 | +14,863+4.19% | Add |
| Rock Springs Capital Management LP |
| 0.28% | 0.3% | #12 | $5.6M | 367,009 | $5.1M | 367,009 | 00.00% | Unchanged |
| Jump Financial, LLC |
| 0.04% | 0.04% | #30 | $5.6M | 361,665 | $3.1M | 221,800 | +139,865+63.06% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #95 | $5.5M | 359,725 | $1.3M | 96,630 | +263,095+272.27% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #93 | $4.8M | 315,271 | $4.4M | 313,648 | +1,623+0.52% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #134 | $4.1M | 270,100 | $10.1M | 727,355 | -457,255-62.87% | Reduce |
| PANAGORA ASSET MANAGEMENT INC |
| 0.01% | — | #42 | $4.1M | 269,113 | $0 | 0 | +269,113 | New Buy |
| Man Group plc |
| 0.01% | 0.01% | #54 | $3.8M | 248,801 | $4.8M | 342,986 | -94,185-27.46% | Reduce |
| BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | 0.02% | #59 | $3.3M | 211,635 | $15.2M | 1.1M | -878,512-80.59% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #83 | $3.2M | 209,593 | $1.5M | 105,300 | +104,293+99.04% | Add |
| Y-Intercept (Hong Kong) Ltd |
| 0.06% | 0.04% | #26 | $3.0M | 196,487 | $1.9M | 139,967 | +56,520+40.38% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #158 | $2.7M | 178,535 | $3.0M | 229,268 | -50,733-22.13% | Reduce |
| Jupiter Topco LLC |
| <0.01% | — | #92 | $2.6M | 172,229 | $0 | 0 | +172,229 | New Buy |
| Allspring Global Investments Holdings, LLC |
| <0.01% | <0.01% | #63 | $2.4M | 166,092 | $2.5M | 168,976 | -2,884-1.71% | Reduce |
| BML Capital Management, LLC |
| 1.36% | 1.38% | #5 | $2.4M | 154,961 | $2.2M | 154,961 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #138 | $2.3M | 150,701 | $3.1M | 219,806 | -69,105-31.44% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #131 | $2.1M | 135,072 | $1.7M | 119,826 | +15,246+12.72% | Add |
| Connor, Clark & Lunn Investment Management Ltd. |
| <0.01% | <0.01% | #61 | $2.1M | 133,870 | $1.7M | 119,376 | +14,494+12.14% | Add |
| THRIVENT FINANCIAL FOR LUTHERANS |
| <0.01% | — | #68 | $1.8M | 115,030 | $0 | 0 | +115,030 | New Buy |
