| RA CAPITAL MANAGEMENT, L.P. |
| 2.04% | 1.78% | #6 | $234.3M | 7.0M | $168.1M | 7.0M | 00.00% | Unchanged |
| TRV GP V, LLC |
| 41.78% | 37.25% | #2 | $208.2M | 6.2M | $149.4M | 6.2M | 00.00% | Unchanged |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.86% | 0.78% | #11 | $148.5M | 4.4M | $105.6M | 4.4M | +37,486+0.85% | Add |
| TRV GP VI, LLC |
| 60.72% | 74.64% | #1 | $141.0M | 4.2M | $101.2M | 4.2M | 00.00% | Unchanged |
| Samsara BioCapital, LLC |
| 8.66% | 7.35% | #3 | $105.5M | 3.1M | $75.7M | 3.1M | 00.00% | Unchanged |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #42 | $102.6M | 3.1M | $69.8M | 2.9M | +156,339+5.38% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #70 | $64.7M | 1.9M | $43.8M | 1.8M | +109,914+6.03% | Add |
| Siren, L.L.C. |
| 1.29% | 1.33% | #9 | $63.6M | 1.9M | $48.1M | 2.0M | -100,000-5.00% | Reduce |
| Avoro Capital Advisors LLC |
| 0.4% | 0.32% | #15 | $44.8M | 1.3M | $32.1M | 1.3M | 00.00% | Unchanged |
| Jupiter Topco LLC |
| 0.02% | — | #37 | $43.7M | 1.3M | $0 | 0 | +1.3M | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #72 | $40.9M | 1.2M | $28.8M | 1.2M | +24,711+2.06% | Add |
| PRIMECAP MANAGEMENT CO/CA/ |
| 0.02% | 0.02% | #33 | $39.1M | 1.2M | $25.2M | 1.0M | +118,548+11.30% | Add |
| First Light Asset Management, LLC |
| 1.96% | 1.58% | #7 | $32.3M | 963,260 | $17.6M | 732,860 | +230,400+31.44% | Add |
| ADAR1 Capital Management, LLC |
| 1.45% | 1.54% | #8 | $31.5M | 940,747 | $26.2M | 1.1M | -149,071-13.68% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #66 | $22.8M | 679,163 | $15.5M | 645,146 | +34,017+5.27% | Add |
| Caption Management, LLC |
| 0.11% | — | #23 | $22.7M | 678,006 | $0 | 0 | +678,006 | New Buy |
| STATE STREET CORP |
| <0.01% | <0.01% | #84 | $21.9M | 652,630 | $15.2M | 631,447 | +21,183+3.35% | Add |
| LOOMIS SAYLES & CO L P |
| 0.03% | — | #31 | $20.9M | 624,752 | $0 | 0 | +624,752 | New Buy |
| Casdin Capital, LLC |
| 0.93% | 1.01% | #10 | $18.5M | 553,268 | $13.3M | 553,268 | 00.00% | Unchanged |
| Catalio Capital Management, LP |
| 3.37% | 1.48% | #5 | $18.0M | 536,152 | $7.1M | 294,360 | +241,792+82.14% | Add |
| ALGERT GLOBAL LLC |
| 0.16% | 0.01% | #21 | $13.3M | 397,487 | $505,000 | 21,035 | +376,452+1,789.65% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | 0.01% | #39 | $11.7M | 350,442 | $5.7M | 236,679 | +113,763+48.07% | Add |
| TUDOR INVESTMENT CORP ET AL |
| 0.02% | — | #38 | $11.0M | 328,966 | $0 | 0 | +328,966 | New Buy |
| Longaeva Partners L.P. |
| 0.22% | 0.07% | #20 | $10.0M | 298,171 | $1.8M | 74,567 | +223,604+299.87% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #79 | $9.9M | 295,900 | $1.8M | 73,000 | +222,900+305.34% | Add |
| Soleus Capital Management, L.P. |
| 0.32% | 0.27% | #16 | $9.2M | 275,000 | $6.6M | 275,000 | 00.00% | Unchanged |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #98 | $7.7M | 230,184 | $4.7M | 195,043 | +35,141+18.02% | Add |
| Universal- Beteiligungs- und Servicegesellschaft mbH |
| 0.01% | 0.01% | #41 | $7.5M | 222,702 | $5.4M | 223,995 | -1,293-0.58% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | <0.01% | #48 | $7.4M | 220,885 | $1.8M | 75,367 | +145,518+193.08% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #78 | $6.7M | 201,131 | $4.0M | 164,530 | +36,601+22.25% | Add |
| Kalehua Capital Management LLC |
| 4.67% | 3.31% | #4 | $6.5M | 194,544 | $4.7M | 194,544 | 00.00% | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #75 | $6.3M | 187,041 | $4.4M | 181,580 | +5,461+3.01% | Add |
| Woodline Partners LP |
| 0.02% | — | #36 | $6.2M | 185,535 | $0 | 0 | +185,535 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #65 | $5.5M | 165,656 | $3.7M | 154,484 | +11,172+7.23% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #113 | $4.5M | 134,377 | $1.0M | 54,458 | +79,919+146.75% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | — | #108 | $3.4M | 102,752 | $0 | 0 | +102,752 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #94 | $3.0M | 89,874 | $2.8M | 116,979 | -27,105-23.17% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #123 | $3.0M | 85,301 | $2.0M | 84,674 | +627+0.74% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | — | #100 | $3.0M | 88,150 | $0 | 0 | +88,150 | New Buy |
| FEDERATED HERMES, INC. |
| <0.01% | <0.01% | #50 | $2.9M | 86,753 | $2.1M | 89,301 | -2,548-2.85% | Reduce |
| LAZARD ASSET MANAGEMENT LLC |
| <0.01% | — | #51 | $2.5M | 75,425 | $0 | 0 | +75,425 | New Buy |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | — | #88 | $2.5M | 75,309 | $0 | 0 | +75,309 | New Buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| <0.01% | — | #67 | $2.5M | 74,649 | $0 | 0 | +74,649 | New Buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.01% | <0.01% | #43 | $2.3M | 68,180 | $683,317 | 28,436 | +39,744+139.77% | Add |
| HUSSMAN STRATEGIC ADVISORS, INC. |
| 0.49% | 0.55% | #12 | $2.1M | 63,000 | $2.5M | 105,000 | -42,000-40.00% | Reduce |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #71 | $2.0M | 60,973 | $1.5M | 61,290 | -317-0.52% | Reduce |
| DIADEMA PARTNERS LP |
| 0.25% | <0.01% | #17 | $2.0M | 59,700 | $4,854 | 202 | +59,498+29,454.46% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #105 | $1.9M | 56,176 | $1.4M | 58,709 | -2,533-4.31% | Reduce |
| XTX Topco Ltd |
| 0.02% | 0.02% | #32 | $1.8M | 54,489 | $882,454 | 36,723 | +17,766+48.38% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #86 | $1.7M | 50,562 | $3.0M | 124,101 | -73,539-59.26% | Reduce |
