| FMR LLC |
| <0.01% | <0.01% | #73 | $111.5M | 19.5M | $58.9M | 10.6M | +8.9M+83.52% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #110 | $77.3M | 13.5M | $60.6M | 10.9M | +2.6M+23.78% | Add |
| Redmile Group, LLC |
| 4.55% | 5.34% | #2 | $67.8M | 11.9M | $80.6M | 14.5M | -2.7M-18.42% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #98 | $56.1M | 9.8M | $38.3M | 6.9M | +2.9M+41.99% | Add |
| BVF INC/IL |
| 1.27% | 1.54% | #7 | $49.7M | 8.7M | $48.2M | 8.7M | 00.00% | Unchanged |
| Woodline Partners LP |
| 0.12% | 0.05% | #21 | $39.5M | 6.9M | $12.9M | 2.3M | +4.6M+196.31% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #124 | $39.2M | 6.9M | $33.0M | 6.0M | +914,426+15.35% | Add |
| MAK CAPITAL ONE LLC |
| 4.69% | 3.86% | #1 | $33.5M | 5.9M | $26.2M | 4.7M | +1.1M+24.09% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #85 | $33.3M | 5.8M | $11.9M | 2.2M | +3.7M+170.59% | Add |
| Siren, L.L.C. |
| 0.52% | 0.61% | #12 | $25.5M | 4.5M | $21.9M | 4.0M | +500,000+12.63% | Add |
| Bain Capital Life Sciences Investors, LLC |
| 1.51% | 2.6% | #6 | $25.3M | 4.4M | $28.9M | 5.2M | -774,943-14.87% | Reduce |
| Bellevue Group AG |
| 0.49% | 0.68% | #13 | $23.4M | 4.1M | $28.6M | 5.2M | -1.1M-20.50% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #108 | $23.1M | 4.0M | $18.7M | 3.4M | +659,370+19.52% | Add |
| MPM BioImpact LLC |
| 1.23% | — | #8 | $20.2M | 3.5M | $0 | 0 | +3.5M | New Buy |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #76 | $20.0M | 3.5M | $19.1M | 3.4M | +60,502+1.75% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.03% | 0.04% | #41 | $20.0M | 3.5M | $23.8M | 4.3M | -800,000-18.60% | Reduce |
| GREAT POINT PARTNERS LLC |
| 3.78% | 3.18% | #3 | $20.0M | 3.5M | $13.9M | 2.5M | +1.0M+40.00% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #117 | $18.0M | 3.1M | $9.2M | 3.0M | +114,605+3.78% | Add |
| Palo Alto Investors LP |
| 2.46% | 2.5% | #5 | $16.8M | 2.9M | $16.3M | 2.9M | 00.00% | Unchanged |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.03% | #46 | $16.2M | 2.8M | $21.5M | 3.9M | -1.1M-27.17% | Reduce |
| Nuveen, LLC |
| <0.01% | 0.01% | #77 | $15.8M | 2.8M | $23.5M | 4.2M | -1.5M-34.88% | Reduce |
| Qube Research & Technologies Ltd |
| 0.01% | 0.02% | #49 | $15.7M | 2.7M | $17.3M | 3.1M | -364,353-11.70% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #135 | $12.8M | 2.2M | $8.2M | 1.5M | +763,710+51.49% | Add |
| Opaleye Management Inc. |
| 0.89% | 1.7% | #10 | $9.8M | 1.7M | $12.9M | 2.3M | -617,310-26.47% | Reduce |
| Logos Global Management LP |
| 0.37% | — | #16 | $8.6M | 1.5M | $0 | 0 | +1.5M | New Buy |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #100 | $8.6M | 1.5M | $5.1M | 924,078 | +573,678+62.08% | Add |
| Point72 Asset Management, L.P. |
| 0.01% | 0.01% | #61 | $7.9M | 1.4M | $10.4M | 1.9M | -489,096-26.13% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #122 | $7.7M | 1.4M | $6.0M | 1.1M | +265,144+24.39% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #116 | $7.2M | 1.3M | $6.1M | 1.1M | +155,354+14.09% | Add |
| Tetragon Partners GP Ltd |
| 1.12% | 1.39% | #9 | $7.1M | 1.2M | $7.2M | 1.3M | -50,000-3.87% | Reduce |
| Candriam S.C.A. |
| 0.03% | — | #39 | $6.8M | 1.2M | $0 | 0 | +1.2M | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #87 | $6.8M | 1.2M | $6.9M | 1.2M | -53,747-4.34% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #102 | $6.3M | 1.1M | $4.9M | 888,552 | +216,898+24.41% | Add |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| <0.01% | <0.01% | #93 | $5.9M | 1.0M | $5.0M | 903,368 | +133,998+14.83% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #157 | $5.6M | 1.0M | $1.6M | 323,894 | +680,414+210.07% | Add |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #121 | $5.6M | 978,055 | $3.9M | 698,739 | +279,316+39.97% | Add |
| PANAGORA ASSET MANAGEMENT INC |
| 0.02% | — | #48 | $5.5M | 967,926 | $0 | 0 | +967,926 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #133 | $5.3M | 920,182 | $4.9M | 887,335 | +32,847+3.70% | Add |
| KENNEDY CAPITAL MANAGEMENT LLC |
| 0.09% | 0.11% | #24 | $5.1M | 898,394 | $5.1M | 912,323 | -13,929-1.53% | Reduce |
| Ishara Investments LP |
| 3.38% | 0.91% | #4 | $4.7M | 820,000 | $965,345 | 174,250 | +645,750+370.59% | Add |
| Ensign Peak Advisors, Inc |
| 0.01% | 0.01% | #64 | $4.6M | 800,516 | $3.5M | 625,097 | +175,419+28.06% | Add |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| <0.01% | — | #94 | $4.2M | 737,935 | $0 | 0 | +737,935 | New Buy |
| Y-Intercept (Hong Kong) Ltd |
| 0.08% | 0.14% | #26 | $4.2M | 734,585 | $7.3M | 1.3M | -585,328-44.35% | Reduce |
| Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #83 | $4.0M | 705,291 | $3.9M | 711,380 | -6,089-0.86% | Reduce |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #103 | $4.0M | 691,812 | $4.3M | 777,253 | -85,441-10.99% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #161 | $3.7M | 641,594 | $2.5M | 457,540 | +184,054+40.23% | Add |
| Parkman Healthcare Partners LLC |
| 0.37% | 0.39% | #15 | $3.7M | 641,029 | $3.7M | 674,013 | -32,984-4.89% | Reduce |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | 0.01% | #75 | $3.6M | 629,127 | $4.2M | 758,232 | -129,105-17.03% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #144 | $3.6M | 623,094 | $7.2M | 1.3M | -672,847-51.92% | Reduce |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #112 | $3.5M | 616,489 | $3.1M | 562,181 | +54,308+9.66% | Add |
