| FMR LLC |
| <0.01% | <0.01% | #60 | $94.3M | 5.1M | $43.0M | 2.9M | +2.2M+77.12% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #78 | $80.7M | 4.4M | $4.9M | 327,082 | +4.0M+1,234.70% | Add |
| Deep Track Capital, LP |
| 0.97% | — | #18 | $66.7M | 3.6M | $0 | 0 | +3.6M | New Buy |
| Caligan Partners LP |
| 2.75% | 1.62% | #2 | $58.5M | 3.2M | $24.4M | 1.6M | +1.5M+93.51% | Add |
| TCG Crossover Management, LLC |
| 1.34% | 0.32% | #12 | $55.8M | 3.0M | $11.0M | 738,383 | +2.3M+308.61% | Add |
| Affinity Asset Advisors, LLC |
| 2.42% | 1.03% | #6 | $53.6M | 2.9M | $20.0M | 1.3M | +1.6M+116.28% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #73 | $53.4M | 2.9M | $1.1M | 71,654 | +2.8M+3,932.28% | Add |
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 0.21% | 0.08% | #32 | $46.2M | 2.5M | $13.7M | 916,000 | +1.6M+172.71% | Add |
| Point72 Asset Management, L.P. |
| 0.05% | 0.02% | #41 | $44.1M | 2.4M | $13.7M | 916,142 | +1.5M+160.55% | Add |
| Avoro Capital Advisors LLC |
| 0.39% | 0.21% | #29 | $43.1M | 2.3M | $21.1M | 1.4M | +923,333+65.48% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #86 | $41.8M | 2.3M | $10.7M | 719,694 | +1.5M+214.61% | Add |
| BVF INC/IL |
| 0.98% | 0.78% | #17 | $38.4M | 2.1M | $24.4M | 1.6M | +442,700+27.11% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #68 | $35.4M | 1.9M | $9.6M | 643,000 | +1.3M+197.64% | Add |
| Nantahala Capital Management, LLC |
| 1.15% | 0.68% | #13 | $34.4M | 1.9M | $18.4M | 1.2M | +627,250+50.79% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.04% | 0.02% | #44 | $32.0M | 1.7M | $12.8M | 854,000 | +875,000+102.46% | Add |
| Soleus Capital Management, L.P. |
| 1.05% | 0.27% | #16 | $30.6M | 1.7M | $6.6M | 441,978 | +1.2M+274.45% | Add |
| BRAIDWELL LP |
| 1.11% | — | #15 | $30.1M | 1.6M | $0 | 0 | +1.6M | New Buy |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #65 | $24.2M | 1.3M | $0 | 0 | +1.3M | New Buy |
| ALLIANCEBERNSTEIN L.P. |
| 0.01% | — | #59 | $23.3M | 1.3M | $0 | 0 | +1.3M | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #63 | $22.3M | 1.2M | $17.0M | 1.1M | +67,079+5.87% | Add |
| Logos Global Management LP |
| 0.91% | 0.97% | #20 | $21.3M | 1.2M | $19.4M | 1.3M | -150,000-11.54% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #80 | $20.4M | 1.1M | $2.5M | 169,889 | +935,229+550.49% | Add |
| Commodore Capital LP |
| 1.12% | 0.42% | #14 | $18.8M | 1.0M | $7.2M | 483,000 | +535,319+110.83% | Add |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.16% | 0.1% | #35 | $18.5M | 1.0M | $9.9M | 662,968 | +337,032+50.84% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #75 | $17.5M | 946,320 | $897,383 | 60,106 | +886,214+1,474.42% | Add |
| Trails Edge Capital Partners, LP |
| 2.62% | — | #3 | $16.5M | 891,881 | $0 | 0 | +891,881 | New Buy |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #61 | $16.5M | 891,405 | $2.6M | 172,149 | +719,256+417.81% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.01% | #50 | $15.9M | 861,711 | $10.9M | 731,586 | +130,125+17.79% | Add |
| Vestal Point Capital, LP |
| 0.33% | — | #31 | $14.3M | 775,000 | $0 | 0 | +775,000 | New Buy |
| Seven Fleet Capital Management LP |
| 2.35% | 1.01% | #8 | $14.2M | 770,765 | $3.2M | 213,819 | +556,946+260.48% | Add |
| Parkman Healthcare Partners LLC |
| 1.45% | — | #11 | $14.2M | 766,290 | $0 | 0 | +766,290 | New Buy |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.17% | 0.09% | #34 | $13.0M | 702,051 | $7.3M | 485,758 | +216,293+44.53% | Add |
| Squarepoint Ops LLC |
| 0.01% | <0.01% | #55 | $10.9M | 589,245 | $1.2M | 81,285 | +507,960+624.91% | Add |
| Caption Management, LLC |
| 0.05% | 0.09% | #43 | $10.3M | 554,800 | $16.2M | 1.1M | -531,900-48.95% | Reduce |
| BAKER BROS. ADVISORS LP |
| 0.05% | — | #40 | $10.2M | 550,000 | $0 | 0 | +550,000 | New Buy |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.96% | — | #19 | $9.2M | 500,402 | $0 | 0 | +500,402 | New Buy |
| Davern Capital Partners, LP |
| 1.48% | — | #10 | $8.7M | 468,666 | $0 | 0 | +468,666 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #82 | $8.3M | 450,233 | $3.9M | 260,535 | +189,698+72.81% | Add |
| Pivotal bioVenture Partners Investment Advisor LLC |
| 2.61% | 1.58% | #4 | $8.0M | 434,033 | $4.4M | 295,933 | +138,100+46.67% | Add |
| FRANKLIN RESOURCES INC |
| <0.01% | — | #74 | $7.5M | 404,191 | $0 | 0 | +404,191 | New Buy |
| Boxer Capital Management, LLC |
| 0.52% | 0.59% | #25 | $6.9M | 375,000 | $4.5M | 300,000 | +75,000+25.00% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | <0.01% | #57 | $6.6M | 357,200 | $1.8M | 120,114 | +237,086+197.38% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #89 | $6.4M | 344,521 | $456,201 | 30,556 | +313,965+1,027.51% | Add |
| DV EQUITIES, LLC |
| 0.88% | — | #21 | $6.1M | 332,213 | $0 | 0 | +332,213 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #76 | $6.0M | 324,808 | $1.3M | 86,434 | +238,374+275.79% | Add |
| Velan Capital Investment Management LP |
| 3.65% | 1.73% | #1 | $6.0M | 324,452 | $2.8M | 185,122 | +139,330+75.26% | Add |
| Schonfeld Strategic Advisors LLC |
| 0.02% | — | #49 | $5.7M | 310,008 | $0 | 0 | +310,008 | New Buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #95 | $5.3M | 285,627 | $9.5M | 637,200 | -351,573-55.17% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #102 | $5.3M | 284,702 | $0 | 0 | +284,702 | New Buy |
| Vivo Capital, LLC |
| 0.46% | — | #27 | $5.1M | 275,000 | $0 | 0 | +275,000 | New Buy |
