| FMR LLC |
| 0.01% | 0.01% | #46 | $202.8M | 9.1M | $99.6M | 7.1M | +2.0M+28.81% | Add |
| Jupiter Topco LLC |
| 0.06% | — | #26 | $139.4M | 6.3M | $0 | 0 | +6.3M | New Buy |
| Fairmount Funds Management LLC |
| 6.69% | 4.62% | #3 | $101.2M | 4.6M | $64.0M | 4.6M | 00.00% | Unchanged |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.71% | 0.55% | #16 | $81.6M | 3.7M | $51.6M | 3.7M | 00.00% | Unchanged |
| Venrock Adviser, LLC |
| 2.17% | 1.69% | #7 | $71.6M | 3.2M | $45.2M | 3.2M | 00.00% | Unchanged |
| Bellevue Group AG |
| 1.43% | 1.17% | #8 | $67.9M | 3.1M | $49.2M | 3.5M | -443,506-12.67% | Reduce |
| Paradigm Biocapital Advisors LP |
| 1.19% | — | #11 | $63.5M | 2.9M | $0 | 0 | +2.9M | New Buy |
| BlackRock, Inc. |
| <0.01% | <0.01% | #81 | $62.2M | 2.8M | $32.5M | 2.3M | +487,502+21.07% | Add |
| FRANKLIN RESOURCES INC |
| 0.01% | — | #41 | $62.0M | 2.8M | $0 | 0 | +2.8M | New Buy |
| STATE STREET CORP |
| <0.01% | <0.01% | #66 | $51.9M | 2.3M | $9.2M | 655,690 | +1.7M+256.16% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #75 | $49.9M | 2.2M | $25.2M | 1.8M | +448,121+24.94% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.06% | — | #25 | $42.5M | 1.9M | $0 | 0 | +1.9M | New Buy |
| Polar Capital Holdings Plc |
| 0.1% | — | #23 | $41.0M | 1.8M | $0 | 0 | +1.8M | New Buy |
| Avidity Partners Management LP |
| 6.05% | 3.99% | #4 | $37.8M | 1.7M | $19.7M | 1.4M | +300,000+21.42% | Add |
| Remedium Capital Partners, LLC |
| 7.76% | 7.88% | #2 | $35.1M | 1.6M | $22.2M | 1.6M | 00.00% | Unchanged |
| Soleus Capital Management, L.P. |
| 1.19% | 0.45% | #12 | $34.5M | 1.6M | $11.2M | 796,744 | +753,946+94.63% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #64 | $32.6M | 1.5M | $210,344 | 15,863 | +1.5M+9,198.87% | Add |
| BAKER BROS. ADVISORS LP |
| 0.14% | 0.13% | #20 | $27.3M | 1.2M | $23.1M | 1.6M | -410,711-25.03% | Reduce |
| Logos Global Management LP |
| 1.08% | 0.28% | #13 | $25.0M | 1.1M | $5.6M | 400,000 | +725,000+181.25% | Add |
| Versant Venture Management, LLC |
| 13.55% | 15.16% | #1 | $22.0M | 991,783 | $21.4M | 1.5M | -534,037-35.00% | Reduce |
| ACORN CAPITAL ADVISORS, LLC |
| 5.98% | 3.14% | #5 | $21.9M | 986,760 | $11.1M | 786,760 | +200,000+25.42% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #74 | $21.9M | 985,178 | $11.6M | 822,520 | +162,658+19.78% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #57 | $20.7M | 929,407 | $1.9M | 137,222 | +792,185+577.30% | Add |
| Foresite Capital Management VI LLC |
| 3.07% | 0.98% | #6 | $19.7M | 886,667 | $4.5M | 320,000 | +566,667+177.08% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.01% | #33 | $19.5M | 878,726 | $5.7M | 402,489 | +476,237+118.32% | Add |
| Affinity Asset Advisors, LLC |
| 0.84% | 0.46% | #15 | $18.7M | 840,350 | $9.0M | 639,956 | +200,394+31.31% | Add |
| Samsara BioCapital, LLC |
| 1.34% | 1.32% | #9 | $16.4M | 736,237 | $13.6M | 968,798 | -232,561-24.01% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #69 | $16.3M | 735,224 | $2.2M | 153,037 | +582,187+380.42% | Add |
| Pictet Asset Management Holding SA |
| 0.02% | — | #38 | $16.3M | 733,768 | $0 | 0 | +733,768 | New Buy |
| Aberdeen Group plc |
| 0.02% | 0.02% | #35 | $13.8M | 621,108 | $12.2M | 867,284 | -246,176-28.38% | Reduce |
| MARSHALL WACE, LLP |
| 0.01% | 0.01% | #43 | $13.0M | 585,761 | $13.3M | 944,776 | -359,015-38.00% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #86 | $10.8M | 486,955 | $542,302 | 38,598 | +448,357+1,161.61% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #96 | $10.3M | 461,528 | $3.0M | 211,319 | +250,209+118.40% | Add |
| Blackstone Inc. |
| 0.03% | — | #31 | $9.7M | 435,320 | $0 | 0 | +435,320 | New Buy |
| Ikarian Capital, LLC |
| 1.01% | 0.58% | #14 | $9.5M | 427,349 | $7.2M | 512,349 | -85,000-16.59% | Reduce |
| Walleye Capital LLC |
| 0.03% | — | #32 | $8.1M | 365,272 | $0 | 0 | +365,272 | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #56 | $7.0M | 314,548 | $2.2M | 160,051 | +154,497+96.53% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #68 | $6.8M | 304,867 | $3.1M | 219,497 | +85,370+38.89% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #82 | $6.6M | 295,081 | $3.4M | 241,905 | +53,176+21.98% | Add |
| LORD, ABBETT & CO. LLC |
| 0.01% | — | #39 | $5.0M | 226,606 | $0 | 0 | +226,606 | New Buy |
| Connor, Clark & Lunn Investment Management Ltd. |
| 0.01% | 0.01% | #44 | $4.8M | 217,157 | $2.4M | 169,051 | +48,106+28.46% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #61 | $4.4M | 199,429 | $402,167 | 28,624 | +170,805+596.72% | Add |
| Jump Financial, LLC |
| 0.03% | <0.01% | #30 | $3.8M | 172,747 | $165,790 | 11,800 | +160,947+1,363.96% | Add |
| Point72 Asset Management, L.P. |
| <0.01% | 0.01% | #51 | $3.7M | 167,204 | $4.0M | 286,715 | -119,511-41.68% | Reduce |
| Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #54 | $3.6M | 163,084 | $1.5M | 107,596 | +55,488+51.57% | Add |
| Opaleye Management Inc. |
| 0.29% | 0.79% | #18 | $3.2M | 145,000 | $6.0M | 427,608 | -282,608-66.09% | Reduce |
| SCHRODER INVESTMENT MANAGEMENT GROUP |
| <0.01% | <0.01% | #59 | $3.1M | 140,886 | $520,840 | 39,279 | +101,607+258.68% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #100 | $2.8M | 127,577 | $913,559 | 65,022 | +62,555+96.21% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #114 | $2.8M | 124,513 | $468,099 | 54,241 | +70,272+129.56% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #112 | $2.6M | 117,343 | $1.1M | 75,908 | +41,435+54.59% | Add |
