| BlackRock, Inc. |
| <0.01% | <0.01% | #82 | $210.7M | 20.7M | $161.3M | 18.0M | +2.7M+14.89% | Add |
| ARCH Venture Management, LLC |
| 11.76% | 17.09% | #2 | $129.4M | 12.7M | $115.7M | 12.9M | -222,500-1.72% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | <0.01% | #68 | $117.1M | 11.5M | $82.6M | 9.2M | +2.3M+24.74% | Add |
| SB INVESTMENT ADVISERS (UK) LTD |
| 1.46% | 1.27% | #7 | $111.6M | 10.9M | $98.1M | 10.9M | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #86 | $101.5M | 10.0M | $64.0M | 7.1M | +2.8M+39.53% | Add |
| GSK plc |
| 14.47% | 12.79% | #1 | $87.1M | 8.6M | $76.6M | 8.6M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #120 | $65.1M | 6.4M | $48.2M | 5.4M | +1.0M+18.70% | Add |
| Point72 Asset Management, L.P. |
| 0.06% | 0.02% | #22 | $57.7M | 5.7M | $17.5M | 2.0M | +3.7M+190.27% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #111 | $34.1M | 3.3M | $23.8M | 2.7M | +690,523+25.98% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| 0.01% | <0.01% | #66 | $31.8M | 3.1M | $23.1M | 2.6M | +539,743+20.92% | Add |
| ADAR1 Capital Management, LLC |
| 1.15% | 1.45% | #10 | $25.0M | 2.5M | $24.6M | 2.7M | -288,037-10.49% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #106 | $24.1M | 2.4M | $29.1M | 3.3M | -885,008-27.23% | Reduce |
| FMR LLC |
| <0.01% | <0.01% | #138 | $23.6M | 2.3M | $18.6M | 2.1M | +246,446+11.89% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #131 | $22.5M | 2.2M | $15.4M | 2.7M | -478,041-17.78% | Reduce |
| Nuveen, LLC |
| <0.01% | <0.01% | #73 | $20.2M | 2.0M | $9.1M | 1.0M | +963,978+94.60% | Add |
| Pictet Asset Management Holding SA |
| 0.02% | 0.01% | #41 | $19.9M | 2.0M | $13.3M | 1.5M | +472,488+31.91% | Add |
| Boxer Capital Management, LLC |
| 1.43% | 2.2% | #8 | $19.0M | 1.9M | $16.7M | 1.9M | 00.00% | Unchanged |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #113 | $14.6M | 1.4M | $8.8M | 985,435 | +446,730+45.33% | Add |
| Hudson Bay Capital Management LP |
| 0.04% | 0.05% | #33 | $13.9M | 1.4M | $13.2M | 1.5M | -105,510-7.18% | Reduce |
| GordonMD Global Investments LP |
| 5.46% | 9.48% | #4 | $13.8M | 1.4M | $13.6M | 1.5M | -165,000-10.87% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #112 | $13.5M | 1.3M | $10.5M | 1.2M | +151,501+12.93% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #146 | $11.6M | 1.1M | $8.7M | 965,814 | +176,725+18.30% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.01% | #59 | $11.3M | 1.1M | $12.9M | 1.4M | -329,267-22.87% | Reduce |
| Sio Capital Management, LLC |
| 1.81% | 1.93% | #6 | $11.0M | 1.1M | $13.4M | 1.5M | -423,346-28.25% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #129 | $10.6M | 1.0M | $19.7M | 2.2M | -1.2M-52.60% | Reduce |
| Savvy Advisors, Inc. |
| 0.23% | — | #17 | $10.6M | 1.0M | $0 | 0 | +1.0M | New Buy |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #50 | $10.4M | 1.0M | $6.8M | 761,364 | +255,500+33.56% | Add |
| Soleus Capital Management, L.P. |
| 0.35% | 0.73% | #16 | $10.2M | 1.0M | $17.9M | 2.0M | -1.0M-50.05% | Reduce |
| SUPERSTRING CAPITAL MANAGEMENT LP |
| 5.49% | 4.68% | #3 | $8.7M | 853,685 | $6.5M | 730,548 | +123,137+16.86% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #110 | $8.6M | 841,557 | $6.6M | 731,721 | +109,836+15.01% | Add |
| Ensign Peak Advisors, Inc |
| 0.01% | 0.02% | #51 | $8.5M | 833,779 | $9.6M | 1.1M | -237,033-22.14% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #160 | $8.3M | 802,597 | $9.5M | 1.1M | -314,919-28.18% | Reduce |
| ALGERT GLOBAL LLC |
| 0.1% | 0.07% | #18 | $8.2M | 804,977 | $4.4M | 489,008 | +315,969+64.61% | Add |
| Saturn V Capital Management LP |
| 1.13% | — | #11 | $7.9M | 770,643 | $0 | 0 | +770,643 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #133 | $7.1M | 694,374 | $5.2M | 584,047 | +110,327+18.89% | Add |
| Jones Hill Capital LP |
| 1.43% | 2.3% | #9 | $6.7M | 659,213 | $10.7M | 1.2M | -539,000-44.98% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #80 | $6.7M | 653,692 | $9.7M | 1.1M | -424,328-39.36% | Reduce |
| Qube Research & Technologies Ltd |
| 0.01% | 0.01% | #65 | $6.5M | 641,486 | $11.2M | 1.2M | -607,183-48.63% | Reduce |
| Candriam S.C.A. |
| 0.03% | 0.03% | #36 | $6.4M | 626,690 | $6.2M | 1.0M | -404,973-39.25% | Reduce |
| Clearstead Advisors, LLC |
| 0.06% | 0.1% | #25 | $6.2M | 608,234 | $10.9M | 1.2M | -608,166-50.00% | Reduce |
| NORDEA INVESTMENT MANAGEMENT AB |
| <0.01% | <0.01% | #72 | $6.1M | 593,776 | $5.1M | 580,755 | +13,021+2.24% | Add |
| PRINCIPAL FINANCIAL GROUP INC |
| <0.01% | <0.01% | #88 | $6.0M | 586,898 | $4.9M | 547,753 | +39,145+7.15% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #107 | $5.9M | 581,416 | $5.1M | 566,009 | +15,407+2.72% | Add |
| Weiss Asset Management LP |
| 0.06% | — | #23 | $5.7M | 555,541 | $0 | 0 | +555,541 | New Buy |
| Avidity Partners Management LP |
| 0.85% | 1.72% | #13 | $5.3M | 519,300 | $8.5M | 950,000 | -430,700-45.34% | Reduce |
| Walleye Capital LLC |
| 0.02% | 0.02% | #42 | $5.3M | 518,751 | $6.0M | 669,884 | -151,133-22.56% | Reduce |
| Alta Partners Management Company, L.P. |
| 4.08% | 3.03% | #5 | $5.2M | 509,917 | $4.6M | 509,917 | 00.00% | Unchanged |
| Invesco Ltd. |
| <0.01% | <0.01% | #171 | $4.8M | 475,545 | $3.8M | 421,332 | +54,213+12.87% | Add |
| Parkman Healthcare Partners LLC |
| 0.5% | 0.46% | #14 | $4.8M | 475,279 | $4.5M | 500,000 | -24,721-4.94% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #154 | $4.7M | 461,334 | $6.7M | 744,142 | -282,808-38.00% | Reduce |
