| Deep Track Capital, LP |
| 2.5% | 1.1% | #14 | $172.1M | 12.2M | $67.3M | 12.2M | 00.00% | Unchanged |
| RTW INVESTMENTS, LP |
| 1.29% | 0.59% | #16 | $151.4M | 10.7M | $58.8M | 10.6M | +68,584+0.65% | Add |
| BIT Capital GmbH |
| 2.66% | 0.93% | #12 | $89.8M | 6.3M | $19.3M | 3.5M | +2.9M+81.85% | Add |
| TANG CAPITAL MANAGEMENT LLC |
| 3.21% | 1.12% | #10 | $70.8M | 5.0M | $22.1M | 4.0M | +997,800+24.93% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.05% | 0.01% | #67 | $63.3M | 4.5M | $14.3M | 2.6M | +1.9M+73.04% | Add |
| MARSHALL WACE, LLP |
| 0.05% | 0.02% | #63 | $61.3M | 4.3M | $22.3M | 4.0M | +290,347+7.19% | Add |
| ARK Investment Management LLC |
| 0.32% | 0.14% | #30 | $48.8M | 3.5M | $18.3M | 3.3M | +150,915+4.57% | Add |
| Caption Management, LLC |
| 0.19% | 0.12% | #38 | $41.2M | 2.9M | $20.0M | 3.6M | -699,014-19.36% | Reduce |
| Point72 Asset Management, L.P. |
| 0.04% | <0.01% | #69 | $37.1M | 2.6M | $130,508 | 23,600 | +2.6M+11,005.42% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #113 | $34.9M | 2.5M | $18.7M | 3.4M | -918,826-27.12% | Reduce |
| Logos Global Management LP |
| 1.37% | — | #15 | $31.8M | 2.3M | $0 | 0 | +2.3M | New Buy |
| Eagle Health Investments LP |
| 4.83% | 1.99% | #5 | $29.2M | 2.1M | $11.4M | 2.1M | 00.00% | Unchanged |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #125 | $28.6M | 2.0M | $178,796 | 32,332 | +2.0M+6,145.66% | Add |
| DAFNA Capital Management LLC |
| 5.43% | 3.04% | #3 | $28.5M | 2.0M | $13.4M | 2.4M | -406,930-16.82% | Reduce |
| NEXTBio Capital Management LP |
| 11.56% | 5.19% | #1 | $25.1M | 1.8M | $11.2M | 2.0M | -245,648-12.15% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #111 | $24.5M | 1.7M | $3.3M | 600,589 | +1.1M+188.08% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #114 | $21.0M | 1.5M | $10.3M | 1.9M | -372,600-20.09% | Reduce |
| Aisling Capital Management LP |
| 4.3% | 1.66% | #7 | $20.3M | 1.4M | $7.9M | 1.4M | 00.00% | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.03% | 0.01% | #80 | $20.3M | 1.4M | $4.8M | 865,354 | +566,535+65.47% | Add |
| Candriam S.C.A. |
| 0.08% | — | #57 | $18.0M | 1.3M | $0 | 0 | +1.3M | New Buy |
| Woodline Partners LP |
| 0.05% | <0.01% | #64 | $15.4M | 1.1M | $970,178 | 175,439 | +910,565+519.02% | Add |
| Jefferies Financial Group Inc. |
| 0.09% | 0.06% | #52 | $14.1M | 994,393 | $8.1M | 1.5M | -472,969-32.23% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #179 | $13.1M | 925,391 | $3.8M | 683,241 | +242,150+35.44% | Add |
| Trexquant Investment LP |
| 0.07% | 0.01% | #58 | $12.2M | 860,158 | $1.7M | 309,283 | +550,875+178.11% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #140 | $12.1M | 854,930 | $2.7M | 485,221 | +369,709+76.19% | Add |
| Kalehua Capital Management LLC |
| 8.31% | 3.21% | #2 | $11.6M | 819,692 | $4.5M | 819,692 | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #106 | $10.9M | 770,987 | $17.4M | 3.1M | -2.4M-75.43% | Reduce |
| Axxion S.A. |
| 0.73% | — | #21 | $10.3M | 727,556 | $0 | 0 | +727,556 | New Buy |
| Creek Drive Management Group LLC |
| 4.75% | 1.04% | #6 | $9.8M | 692,000 | $4.6M | 825,000 | -133,000-16.12% | Reduce |
| Eversept Partners, LP |
| 0.49% | 0.2% | #26 | $9.5M | 672,825 | $3.7M | 677,924 | -5,099-0.75% | Reduce |
| Squadron Capital Management LLC |
| 2.66% | — | #13 | $8.6M | 605,000 | $0 | 0 | +605,000 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #164 | $8.4M | 594,906 | $5.9M | 1.0M | -435,399-42.26% | Reduce |
| Propel Bio Management, LLC |
| 4.24% | 2.6% | #9 | $8.1M | 573,086 | $4.1M | 742,049 | -168,963-22.77% | Reduce |
| Occam Crest Management LP |
| 4.25% | — | #8 | $7.7M | 710,000 | $0 | 0 | +710,000 | New Buy |
| Walleye Capital LLC |
| 0.03% | 0.01% | #81 | $7.3M | 515,165 | $2.2M | 391,552 | +123,613+31.57% | Add |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.74% | 0.17% | #20 | $7.1M | 503,382 | $1.7M | 300,000 | +203,382+67.79% | Add |
| Qube Research & Technologies Ltd |
| 0.01% | 0.01% | #96 | $7.1M | 499,676 | $5.2M | 948,554 | -448,878-47.32% | Reduce |
| Ensign Peak Advisors, Inc |
| 0.01% | <0.01% | #91 | $6.7M | 474,653 | $216,914 | 39,225 | +435,428+1,110.08% | Add |
| Blue Owl Capital Holdings LP |
| 0.93% | 1.38% | #19 | $6.4M | 450,000 | $5.1M | 1.8M | -1.4M-75.06% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #160 | $6.1M | 432,887 | $2.3M | 412,997 | +19,890+4.82% | Add |
| AdvisorShares Investments LLC |
| 0.72% | 0.25% | #22 | $6.0M | 421,347 | $1.4M | 246,739 | +174,608+70.77% | Add |
| Hennion & Walsh Asset Management, Inc. |
| 0.17% | 0.09% | #42 | $5.9M | 417,833 | $2.7M | 487,674 | -69,841-14.32% | Reduce |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. |
| 0.35% | 0.02% | #28 | $5.4M | 384,351 | $378,722 | 68,485 | +315,866+461.22% | Add |
| HighVista Strategies LLC |
| 1.2% | 0.56% | #17 | $5.3M | 371,120 | $2.0M | 364,360 | +6,760+1.86% | Add |
| Legal & General Group Plc |
| <0.01% | <0.01% | #143 | $4.7M | 332,206 | $1.3M | 231,385 | +100,821+43.57% | Add |
| Sumitomo Mitsui Trust Group, Inc. |
| <0.01% | <0.01% | #115 | $4.6M | 323,209 | $2.0M | 368,828 | -45,619-12.37% | Reduce |
| Amova Asset Management Americas, Inc. |
| 0.06% | 0.03% | #61 | $4.5M | 319,472 | $2.0M | 368,828 | -49,356-13.38% | Reduce |
| Affinity Asset Advisors, LLC |
| 0.19% | 0.32% | #37 | $4.3M | 301,183 | $6.1M | 1.1M | -807,300-72.83% | Reduce |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | <0.01% | #97 | $4.2M | 300,000 | $1.7M | 300,000 | 00.00% | Unchanged |
| SEVEN GRAND MANAGERS, LLC |
| 0.17% | 0.11% | #41 | $4.2M | 300,000 | $1.7M | 300,000 | 00.00% | Unchanged |