| RTW INVESTMENTS, LP |
| 1.43% | 0.81% | #8 | $167.2M | 4.5M | $81.7M | 4.5M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #91 | $117.8M | 3.2M | $51.2M | 2.8M | +355,894+12.51% | Add |
| MORGAN STANLEY |
| 0.01% | <0.01% | #61 | $94.8M | 2.6M | $50.4M | 2.5M | +47,917+1.90% | Add |
| Kynam Capital Management, LP |
| 4.95% | 2.49% | #3 | $89.6M | 2.4M | $40.4M | 2.2M | +186,814+8.31% | Add |
| Jefferies Financial Group Inc. |
| 0.53% | 0.27% | #16 | $80.9M | 2.2M | $39.5M | 2.2M | 00.00% | Unchanged |
| SG Americas Securities, LLC |
| 0.04% | 0.03% | #39 | $75.5M | 2.1M | $29.8M | 1.7M | +395,060+23.83% | Add |
| AMERICAN CENTURY COMPANIES INC |
| 0.03% | 0.02% | #41 | $62.0M | 1.7M | $29.4M | 1.6M | +48,149+2.94% | Add |
| ACORN CAPITAL ADVISORS, LLC |
| 16.8% | 8.55% | #1 | $61.6M | 1.7M | $30.1M | 1.7M | 00.00% | Unchanged |
| Point72 Asset Management, L.P. |
| 0.06% | — | #36 | $56.1M | 1.5M | $0 | 0 | +1.5M | New Buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC |
| 0.52% | 0.24% | #17 | $55.5M | 1.5M | $23.6M | 1.3M | +194,435+14.80% | Add |
| Opaleye Management Inc. |
| 4.8% | 3.39% | #4 | $53.0M | 1.4M | $25.7M | 1.4M | +9,996+0.70% | Add |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 4.98% | 2.76% | #2 | $47.9M | 1.3M | $27.0M | 1.5M | -201,066-13.38% | Reduce |
| MENORA MIVTACHIM HOLDINGS LTD. |
| 0.17% | 0.1% | #30 | $42.4M | 1.2M | $20.7M | 1.2M | 00.00% | Unchanged |
| D. E. Shaw & Co., Inc. |
| 0.02% | 0.01% | #46 | $42.2M | 1.1M | $18.4M | 1.0M | +122,660+11.99% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #106 | $36.9M | 1.0M | $15.7M | 874,176 | +128,895+14.74% | Add |
| MPM BioImpact LLC |
| 2.09% | 1.31% | #7 | $34.3M | 933,415 | $17.0M | 943,803 | -10,388-1.10% | Reduce |
| Soleus Capital Management, L.P. |
| 1.05% | 0.53% | #12 | $30.5M | 829,810 | $13.1M | 727,000 | +102,810+14.14% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #79 | $30.2M | 819,834 | $10.8M | 598,528 | +221,306+36.98% | Add |
| Migdal Insurance & Financial Holdings Ltd. |
| 0.18% | 0.12% | #27 | $28.4M | 770,909 | $13.9M | 770,909 | 00.00% | Unchanged |
| ORBIMED ADVISORS LLC |
| 0.47% | 0.31% | #19 | $24.9M | 676,187 | $15.7M | 875,487 | -199,300-22.76% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #104 | $22.5M | 610,364 | $9.4M | 523,831 | +86,533+16.52% | Add |
| Woodline Partners LP |
| 0.06% | 0.03% | #37 | $18.4M | 500,726 | $9.0M | 500,726 | 00.00% | Unchanged |
| Boxer Capital Management, LLC |
| 1.39% | 1.18% | #10 | $18.4M | 500,000 | $9.0M | 500,000 | 00.00% | Unchanged |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #105 | $17.5M | 475,702 | $2.3M | 126,783 | +348,919+275.21% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #118 | $16.8M | 456,558 | $7.4M | 409,557 | +47,001+11.48% | Add |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND |
| 0.02% | 0.01% | #47 | $14.2M | 387,074 | $7.0M | 387,074 | 00.00% | Unchanged |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #100 | $11.2M | 304,570 | $5.0M | 275,938 | +28,632+10.38% | Add |
| RICE HALL JAMES & ASSOCIATES, LLC |
| 0.54% | 0.29% | #15 | $11.1M | 300,650 | $5.1M | 285,834 | +14,816+5.18% | Add |
| Hennion & Walsh Asset Management, Inc. |
| 0.29% | 0.11% | #21 | $10.2M | 276,696 | $3.3M | 183,504 | +93,192+50.78% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #116 | $9.9M | 268,082 | $5.7M | 317,423 | -49,341-15.54% | Reduce |
| ADAR1 Capital Management, LLC |
| 0.43% | 0.42% | #20 | $9.3M | 252,395 | $7.1M | 395,459 | -143,064-36.18% | Reduce |
| J. Goldman & Co LP |
| 0.23% | 0.52% | #24 | $9.1M | 246,775 | $17.8M | 988,870 | -742,095-75.04% | Reduce |
| Privium Fund Management B.V. |
| 1.42% | 0.89% | #9 | $7.7M | 210,000 | $4.3M | 238,122 | -28,122-11.81% | Reduce |
| FMR LLC |
| <0.01% | <0.01% | #140 | $7.3M | 197,098 | $2.6M | 144,961 | +52,137+35.97% | Add |
| SUPERSTRING CAPITAL MANAGEMENT LP |
| 4.44% | 4.98% | #5 | $7.0M | 191,313 | $7.0M | 387,371 | -196,058-50.61% | Reduce |
| Parkman Healthcare Partners LLC |
| 0.66% | 0.51% | #14 | $6.4M | 174,064 | $4.9M | 275,000 | -100,936-36.70% | Reduce |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #90 | $5.5M | 149,228 | $2.6M | 144,060 | +5,168+3.59% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #64 | $5.5M | 148,963 | $3.2M | 177,901 | -28,938-16.27% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #124 | $4.7M | 128,370 | $1.6M | 88,466 | +39,904+45.11% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #126 | $4.5M | 121,461 | $2.9M | 159,658 | -38,197-23.92% | Reduce |
| Elmind Capital, LP |
| 1.11% | 1.12% | #11 | $4.4M | 120,000 | $4.0M | 220,000 | -100,000-45.45% | Reduce |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #120 | $4.2M | 115,362 | $1.8M | 100,215 | +15,147+15.11% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #122 | $4.2M | 113,028 | $1.8M | 98,942 | +14,086+14.24% | Add |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
| 0.02% | 0.02% | #49 | $4.1M | 111,141 | $4.1M | 230,630 | -119,489-51.81% | Reduce |
| Aisling Capital Management LP |
| 0.84% | 0.41% | #13 | $4.0M | 108,000 | $1.9M | 108,000 | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #99 | $3.9M | 106,692 | $6.7M | 370,898 | -264,206-71.23% | Reduce |
| Tidal Investments LLC |
| 0.01% | <0.01% | #59 | $3.7M | 101,837 | $1.9M | 102,949 | -1,112-1.08% | Reduce |
| ARK Investment Management LLC |
| 0.02% | 0.02% | #42 | $3.7M | 101,508 | $2.1M | 115,545 | -14,037-12.15% | Reduce |
| Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #77 | $3.5M | 94,979 | $1.1M | 63,246 | +31,733+50.17% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #114 | $3.4M | 92,102 | $1.6M | 87,522 | +4,580+5.23% | Add |
