| FMR LLC |
| 0.01% | 0.01% | #53 | $151.9M | 12.1M | $154.9M | 10.4M | +1.8M+16.91% | Add |
| Paradigm Biocapital Advisors LP |
| 2.03% | 2.44% | #2 | $108.5M | 8.7M | $119.6M | 8.0M | +650,000+8.10% | Add |
| Jupiter Topco LLC |
| 0.04% | — | #32 | $88.8M | 7.1M | $0 | 0 | +7.1M | New Buy |
| Bain Capital Life Sciences Investors, LLC |
| 5.27% | 10.05% | #1 | $88.6M | 7.1M | $111.4M | 7.5M | -387,989-5.19% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #83 | $84.0M | 6.7M | $84.3M | 5.7M | +1.1M+18.80% | Add |
| BVF INC/IL |
| 1.69% | 2.52% | #4 | $66.3M | 5.3M | $79.0M | 5.3M | 00.00% | Unchanged |
| Siren, L.L.C. |
| 1.23% | 1.97% | #9 | $60.8M | 4.9M | $70.9M | 4.8M | +100,000+2.10% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #76 | $54.0M | 4.3M | $58.7M | 3.9M | +378,227+9.60% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #99 | $41.8M | 3.3M | $46.0M | 3.1M | +257,700+8.36% | Add |
| Logos Global Management LP |
| 1.73% | 2.39% | #3 | $40.1M | 3.2M | $47.8M | 3.2M | 00.00% | Unchanged |
| FRANKLIN RESOURCES INC |
| 0.01% | <0.01% | #54 | $29.4M | 2.3M | $18.2M | 1.2M | +1.1M+92.75% | Add |
| Cormorant Asset Management, LP |
| 1.37% | 3.29% | #8 | $26.9M | 2.2M | $65.6M | 4.4M | -2.3M-51.14% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #85 | $22.9M | 1.8M | $15.2M | 1.6M | +276,382+17.76% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #84 | $22.8M | 1.8M | $23.0M | 1.5M | +274,612+17.78% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #97 | $20.8M | 1.7M | $8.8M | 593,031 | +1.1M+180.46% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #74 | $19.6M | 1.6M | $18.7M | 1.3M | +315,290+25.17% | Add |
| Deep Track Capital, LP |
| 0.27% | — | #16 | $18.8M | 1.5M | $0 | 0 | +1.5M | New Buy |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #61 | $17.7M | 1.4M | $16.1M | 1.1M | +334,099+30.87% | Add |
| Lightspeed Management Company, L.L.C. |
| 0.71% | 2.05% | #13 | $17.0M | 1.4M | $20.2M | 1.4M | 00.00% | Unchanged |
| KINGDON CAPITAL MANAGEMENT, L.L.C. |
| 1.54% | 1.4% | #6 | $15.0M | 1.2M | $12.7M | 855,000 | +345,000+40.35% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.01% | #48 | $14.2M | 1.1M | $17.4M | 1.2M | -37,987-3.25% | Reduce |
| Point72 Asset Management, L.P. |
| 0.02% | <0.01% | #42 | $13.7M | 1.1M | $1.6M | 109,707 | +983,642+896.61% | Add |
| Duquesne Family Office LLC |
| 0.24% | 0.44% | #17 | $12.3M | 986,827 | $14.7M | 986,827 | 00.00% | Unchanged |
| Defilade Capital Management, L.P. |
| 1.55% | 3.15% | #5 | $11.6M | 924,758 | $22.4M | 1.5M | -579,778-38.54% | Reduce |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #71 | $10.5M | 840,646 | $855,268 | 57,362 | +783,284+1,365.51% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #91 | $10.3M | 826,569 | $17.6M | 1.2M | -356,267-30.12% | Reduce |
| Woodline Partners LP |
| 0.03% | 0.08% | #36 | $9.4M | 751,030 | $22.1M | 1.5M | -731,000-49.32% | Reduce |
| Candriam S.C.A. |
| 0.04% | 0.08% | #31 | $9.4M | 751,133 | $17.0M | 679,484 | +71,649+10.54% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #90 | $9.1M | 725,628 | $16.5M | 1.1M | -380,704-34.41% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #93 | $8.4M | 674,945 | $8.5M | 569,956 | +104,989+18.42% | Add |
| Vivo Capital, LLC |
| 0.77% | 0.83% | #12 | $8.4M | 671,843 | $10.0M | 671,843 | 00.00% | Unchanged |
| Qube Research & Technologies Ltd |
| 0.01% | 0.01% | #51 | $8.3M | 663,319 | $4.7M | 312,812 | +350,507+112.05% | Add |
| Squarepoint Ops LLC |
| 0.01% | 0.02% | #50 | $7.7M | 615,470 | $12.8M | 858,552 | -243,082-28.31% | Reduce |
| Ikarian Capital, LLC |
| 0.77% | 1.39% | #11 | $7.3M | 583,281 | $17.1M | 1.1M | -564,800-49.20% | Reduce |
| Jones Hill Capital LP |
| 1.53% | — | #7 | $7.2M | 574,166 | $0 | 0 | +574,166 | New Buy |
| Hudson Bay Capital Management LP |
| 0.02% | 0.01% | #37 | $7.1M | 566,400 | $2.3M | 154,770 | +411,630+265.96% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #88 | $6.6M | 526,446 | $9.9M | 664,679 | -138,233-20.80% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #101 | $6.5M | 518,342 | $7.0M | 466,546 | +51,796+11.10% | Add |
| Hennion & Walsh Asset Management, Inc. |
| 0.15% | 0.24% | #19 | $5.3M | 420,211 | $7.2M | 481,485 | -61,274-12.73% | Reduce |
| Vestal Point Capital, LP |
| 0.12% | 0.18% | #21 | $5.2M | 418,551 | $6.4M | 428,551 | -10,000-2.33% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #87 | $5.2M | 415,055 | $5.3M | 358,310 | +56,745+15.84% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #125 | $5.1M | 410,952 | $18.0M | 1.2M | -796,430-65.96% | Reduce |
| SEB Asset Management AB |
| 0.02% | 0.02% | #41 | $4.2M | 339,461 | $5.1M | 339,461 | 00.00% | Unchanged |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #137 | $4.2M | 334,875 | $7.6M | 508,706 | -173,831-34.17% | Reduce |
| Fisher Asset Management, LLC |
| <0.01% | <0.01% | #89 | $3.7M | 296,724 | $4.5M | 299,756 | -3,032-1.01% | Reduce |
| Rock Springs Capital Management LP |
| 0.14% | 0.15% | #20 | $2.9M | 235,178 | $2.5M | 170,378 | +64,800+38.03% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #127 | $2.8M | 222,873 | $5.7M | 385,061 | -162,188-42.12% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #121 | $2.8M | 222,177 | $2.9M | 193,483 | +28,694+14.83% | Add |
| Pier Capital, LLC |
| 0.37% | 0.33% | #15 | $2.8M | 220,699 | $2.0M | 136,108 | +84,591+62.15% | Add |
| Birchview Capital, LP |
| 1.13% | 1.86% | #10 | $2.5M | 199,000 | $3.3M | 219,000 | -20,000-9.13% | Reduce |
