| MONTANOVA CAPITAL, LLC |
| 2.17% | 2.73% | #7 | $118.6M | 8.3M | $106.9M | 8.3M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #91 | $106.7M | 7.5M | $92.5M | 7.2M | +285,860+3.98% | Add |
| Cormorant Asset Management, LP |
| 5.08% | 5.35% | #3 | $100.1M | 7.0M | $106.5M | 8.3M | -1.3M-15.31% | Reduce |
| FEDERATED HERMES, INC. |
| 0.12% | 0.12% | #29 | $81.2M | 5.7M | $73.1M | 5.7M | +11,463+0.20% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.1% | 0.07% | #32 | $69.0M | 4.8M | $42.5M | 3.3M | +1.5M+46.30% | Add |
| FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #54 | $68.7M | 4.8M | $65.1M | 5.0M | -241,520-4.78% | Reduce |
| Commodore Capital LP |
| 3.92% | 2.11% | #5 | $65.8M | 4.6M | $36.4M | 2.8M | +1.8M+62.83% | Add |
| Jupiter Topco LLC |
| 0.02% | — | #48 | $53.9M | 3.8M | $0 | 0 | +3.8M | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #109 | $51.9M | 3.6M | $45.9M | 3.6M | +70,683+1.99% | Add |
| Paradigm Biocapital Advisors LP |
| 0.77% | 0.83% | #16 | $41.3M | 2.9M | $40.5M | 3.1M | -252,040-8.02% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #113 | $33.7M | 2.4M | $27.0M | 2.1M | +260,343+12.41% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #70 | $32.2M | 2.3M | $25.8M | 2.0M | +246,235+12.28% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #92 | $29.5M | 2.1M | $25.6M | 2.0M | +78,725+3.97% | Add |
| Aberdeen Group plc |
| 0.04% | 0.04% | #42 | $28.7M | 2.0M | $22.4M | 1.7M | +270,424+15.56% | Add |
| PERCEPTIVE ADVISORS LLC |
| 0.43% | — | #20 | $28.6M | 2.0M | $0 | 0 | +2.0M | New Buy |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.03% | 0.02% | #46 | $25.9M | 1.8M | $18.5M | 1.4M | +373,621+25.97% | Add |
| Parkman Healthcare Partners LLC |
| 1.89% | 1.8% | #9 | $18.4M | 1.3M | $17.5M | 1.4M | -66,637-4.92% | Reduce |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 0.24% | 0.27% | #22 | $17.8M | 1.2M | $16.1M | 1.2M | 00.00% | Unchanged |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | <0.01% | #57 | $16.9M | 1.2M | $5.5M | 430,315 | +750,828+174.48% | Add |
| Essex Woodlands Management, Inc. |
| 6.1% | 5.58% | #1 | $15.5M | 1.1M | $14.0M | 1.1M | 00.00% | Unchanged |
| ORBIMED ADVISORS LLC |
| 0.29% | 0.27% | #21 | $15.3M | 1.1M | $13.8M | 1.1M | 00.00% | Unchanged |
| 5AM Venture Management, LLC |
| 5.22% | 3.76% | #2 | $15.0M | 1.1M | $13.5M | 1.1M | 00.00% | Unchanged |
| Rosalind Advisors, Inc. |
| 3.35% | 5.37% | #6 | $14.1M | 988,230 | $13.4M | 1.0M | -48,507-4.68% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #125 | $13.9M | 971,014 | $10.2M | 793,870 | +177,144+22.31% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #80 | $12.1M | 848,410 | $5.5M | 423,262 | +425,148+100.45% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #84 | $12.0M | 841,746 | $5.2M | 401,121 | +440,625+109.85% | Add |
| HSBC HOLDINGS PLC |
| <0.01% | 0.01% | #67 | $11.9M | 833,455 | $10.7M | 833,455 | 00.00% | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #114 | $11.3M | 790,321 | $8.9M | 692,281 | +98,040+14.16% | Add |
| Candriam S.C.A. |
| 0.05% | 0.06% | #38 | $11.3M | 787,769 | $12.3M | 674,395 | +113,374+16.81% | Add |
| Artia Global Partners LP |
| 2.02% | 1.98% | #8 | $11.0M | 767,098 | $9.9M | 767,098 | 00.00% | Unchanged |
| Blue Owl Capital Holdings LP |
| 1.59% | 3.16% | #11 | $10.9M | 762,594 | $11.8M | 912,594 | -150,000-16.44% | Reduce |
| Ikarian Capital, LLC |
| 1.12% | 0.78% | #14 | $10.6M | 740,800 | $9.5M | 740,800 | 00.00% | Unchanged |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #104 | $10.3M | 720,917 | $8.7M | 676,812 | +44,105+6.52% | Add |
| Patient Square Capital LP |
| 1.59% | 1.82% | #10 | $10.3M | 720,000 | $10.2M | 795,000 | -75,000-9.43% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #102 | $9.3M | 647,613 | $8.3M | 640,123 | +7,490+1.17% | Add |
| Sio Capital Management, LLC |
| 1.47% | 1.33% | #12 | $8.9M | 623,130 | $9.3M | 721,785 | -98,655-13.67% | Reduce |
| Principia Wealth Advisory, LLC |
| 4.62% | — | #4 | $8.2M | 633,764 | $0 | 0 | +633,764 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #87 | $8.0M | 559,216 | $6.5M | 504,472 | +54,744+10.85% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #119 | $7.7M | 535,187 | $9.9M | 769,806 | -234,619-30.48% | Reduce |
| Alyeska Investment Group, L.P. |
| 0.02% | 0.02% | #50 | $7.3M | 509,403 | $6.6M | 509,403 | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #82 | $7.2M | 500,093 | $6.1M | 475,190 | +24,903+5.24% | Add |
| Simplify Asset Management Inc. |
| 0.08% | 0.06% | #34 | $5.7M | 400,044 | $4.2M | 326,142 | +73,902+22.66% | Add |
| Ghisallo Capital Management LLC |
| 0.03% | — | #47 | $5.0M | 350,000 | $0 | 0 | +350,000 | New Buy |
| STEMPOINT CAPITAL LP |
| 0.69% | 1.93% | #17 | $4.8M | 338,471 | $10.5M | 810,764 | -472,293-58.25% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #148 | $4.8M | 336,730 | $13.9M | 978,129 | -641,399-65.57% | Reduce |
| E Fund Management Co., Ltd. |
| 0.11% | 0.04% | #30 | $4.7M | 330,774 | $1.2M | 94,500 | +236,274+250.03% | Add |
| Jump Financial, LLC |
| 0.04% | 0.03% | #44 | $4.6M | 320,757 | $2.6M | 198,400 | +122,357+61.67% | Add |
| Bleichroeder LP |
| 0.81% | 0.71% | #15 | $4.5M | 316,515 | $4.1M | 316,515 | 00.00% | Unchanged |
| Woodline Partners LP |
| 0.01% | <0.01% | #56 | $4.3M | 300,463 | $1.3M | 100,463 | +200,000+199.08% | Add |
| Eversept Partners, LP |
| 0.22% | — | #25 | $4.3M | 297,735 | $0 | 0 | +297,735 | New Buy |
