| FMR LLC |
| 0.01% | 0.01% | #44 | $263.2M | 17.4M | $186.1M | 17.1M | +303,929+1.78% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #81 | $203.2M | 13.4M | $143.8M | 13.2M | +219,934+1.67% | Add |
| Soleus Capital Management, L.P. |
| 5.18% | 4.63% | #1 | $150.2M | 9.9M | $114.4M | 10.5M | -578,990-5.52% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #67 | $95.0M | 6.3M | $68.1M | 6.3M | +20,789+0.33% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #106 | $74.3M | 4.9M | $51.0M | 4.7M | +221,569+4.73% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #74 | $68.5M | 4.5M | $11.8M | 916,154 | +3.6M+393.63% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #114 | $43.4M | 2.9M | $27.9M | 2.6M | +304,729+11.90% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #93 | $42.4M | 2.8M | $27.4M | 2.5M | +286,644+11.41% | Add |
| WELLS FARGO & COMPANY/MN |
| 0.01% | 0.01% | #54 | $39.6M | 2.6M | $34.0M | 3.1M | -508,144-16.28% | Reduce |
| Quantinno Capital Management LP |
| 0.04% | 0.05% | #21 | $33.7M | 2.2M | $27.1M | 2.5M | -263,921-10.61% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.04% | 0.03% | #20 | $29.6M | 2.0M | $16.9M | 1.6M | +400,357+25.80% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #109 | $25.9M | 1.7M | $9.6M | 930,166 | +740,916+79.65% | Add |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND |
| 0.03% | 0.01% | #24 | $21.0M | 1.4M | $7.9M | 726,400 | +659,200+90.75% | Add |
| Palo Alto Investors LP |
| 2.83% | 2.13% | #2 | $19.4M | 1.3M | $14.0M | 1.3M | 00.00% | Unchanged |
| Nuveen, LLC |
| <0.01% | <0.01% | #62 | $18.7M | 1.2M | $10.7M | 982,353 | +249,734+25.42% | Add |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.06% | 0.06% | #17 | $17.6M | 1.2M | $14.5M | 1.3M | -167,420-12.57% | Reduce |
| Empowered Funds, LLC |
| 0.09% | — | #14 | $17.5M | 1.2M | $0 | 0 | +1.2M | New Buy |
| AQR CAPITAL MANAGEMENT LLC |
| 0.01% | <0.01% | #56 | $16.7M | 1.1M | $2.9M | 274,932 | +827,199+300.87% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #82 | $16.5M | 1.1M | $10.5M | 960,056 | +131,890+13.74% | Add |
| D. E. Shaw & Co., Inc. |
| 0.01% | <0.01% | #51 | $15.5M | 1.0M | $7.1M | 647,062 | +375,418+58.02% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #101 | $14.7M | 973,202 | $9.6M | 883,578 | +89,624+10.14% | Add |
| C WorldWide Group Holding A/S |
| 0.36% | 0.23% | #5 | $14.7M | 971,784 | $10.6M | 971,784 | 00.00% | Unchanged |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #116 | $14.6M | 963,917 | $8.1M | 745,435 | +218,482+29.31% | Add |
| BAILLIE GIFFORD & CO |
| 0.01% | 0.01% | #42 | $14.4M | 952,074 | $11.7M | 1.1M | -119,510-11.15% | Reduce |
| SILVERCREST ASSET MANAGEMENT GROUP LLC |
| 0.09% | 0.06% | #13 | $14.1M | 928,740 | $8.6M | 784,805 | +143,935+18.34% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #100 | $14.0M | 923,670 | $9.1M | 837,494 | +86,176+10.29% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.01% | <0.01% | #52 | $14.0M | 922,009 | $7.7M | 708,293 | +213,716+30.17% | Add |
| ALGERT GLOBAL LLC |
| 0.15% | 0.1% | #7 | $13.0M | 856,322 | $6.8M | 625,797 | +230,525+36.84% | Add |
| Point72 Asset Management, L.P. |
| 0.01% | 0.02% | #40 | $12.2M | 803,120 | $14.8M | 1.4M | -558,271-41.01% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #133 | $11.6M | 762,724 | $1.9M | 170,013 | +592,711+348.63% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #91 | $11.4M | 752,531 | $7.8M | 712,769 | +39,762+5.58% | Add |
| Connor, Clark & Lunn Investment Management Ltd. |
| 0.02% | 0.02% | #31 | $10.0M | 661,280 | $7.8M | 716,539 | -55,259-7.71% | Reduce |
| Qube Research & Technologies Ltd |
| 0.01% | <0.01% | #48 | $9.2M | 605,874 | $1.7M | 156,622 | +449,252+286.84% | Add |
| PANAGORA ASSET MANAGEMENT INC |
| 0.03% | <0.01% | #26 | $8.2M | 540,687 | $840,630 | 77,122 | +463,565+601.08% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | <0.01% | #46 | $7.3M | 479,999 | $128,958 | 11,831 | +468,168+3,957.13% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #149 | $7.0M | 462,844 | $15.3M | 1.4M | -939,031-66.98% | Reduce |
| ESSEX INVESTMENT MANAGEMENT CO LLC |
| 0.87% | 0.78% | #3 | $6.7M | 439,648 | $4.9M | 452,370 | -12,722-2.81% | Reduce |
| FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #112 | $6.6M | 434,360 | $3.2M | 289,296 | +145,064+50.14% | Add |
| SCHRODER INVESTMENT MANAGEMENT GROUP |
| <0.01% | 0.01% | #60 | $6.4M | 415,340 | $10.6M | 1.0M | -604,629-59.28% | Reduce |
| CITIGROUP INC |
| <0.01% | <0.01% | #97 | $6.3M | 415,517 | $1.5M | 137,010 | +278,507+203.27% | Add |
| HRT FINANCIAL LP |
| 0.01% | — | #45 | $5.9M | 392,319 | $0 | 0 | +392,319 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #141 | $5.7M | 373,735 | $2.2M | 198,236 | +175,499+88.53% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #157 | $5.1M | 336,950 | $1.0M | 93,100 | +243,850+261.92% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #140 | $5.1M | 336,638 | $3.2M | 289,817 | +46,821+16.16% | Add |
| Legal & General Group Plc |
| <0.01% | <0.01% | #125 | $4.9M | 325,809 | $3.6M | 330,937 | -5,128-1.55% | Reduce |
| Coppell Advisory Solutions LLC |
| 0.4% | — | #4 | $4.9M | 38,953 | $0 | 0 | +38,953 | New Buy |
| Jump Financial, LLC |
| 0.04% | 0.05% | #22 | $4.7M | 311,349 | $4.0M | 368,377 | -57,028-15.48% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #131 | $4.6M | 305,516 | $3.1M | 281,471 | +24,045+8.54% | Add |
| Susquehanna Portfolio Strategies, LLC |
| 0.07% | 0.02% | #16 | $4.4M | 288,772 | $1.5M | 139,700 | +149,072+106.71% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #110 | $4.2M | 278,068 | $994,244 | 91,215 | +186,853+204.85% | Add |
