| FMR LLC |
| 0.01% | <0.01% | #62 | $294.5M | 25.4M | $67.7M | 22.6M | +2.9M+12.68% | Add |
| ARK Investment Management LLC |
| 0.97% | 0.32% | #7 | $149.8M | 12.9M | $41.2M | 13.7M | -800,898-5.83% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #94 | $141.1M | 12.2M | $33.8M | 11.3M | +920,108+8.17% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #86 | $93.8M | 8.1M | $22.0M | 7.3M | +772,450+10.55% | Add |
| AMERIPRISE FINANCIAL INC |
| 0.02% | <0.01% | #54 | $81.0M | 7.0M | $9.5M | 3.2M | +3.8M+119.86% | Add |
| Redmile Group, LLC |
| 5.24% | 1.64% | #2 | $78.1M | 6.7M | $24.8M | 8.3M | -1.5M-18.34% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #106 | $71.0M | 6.1M | $0 | 0 | +6.1M | New Buy |
| ADVANCED MICRO DEVICES INC |
| 5.05% | 9.83% | #3 | $66.2M | 5.7M | $17.1M | 5.7M | 00.00% | Unchanged |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.09% | — | #29 | $66.1M | 5.7M | $0 | 0 | +5.7M | New Buy |
| TWO SIGMA INVESTMENTS, LP |
| 0.05% | 0.01% | #36 | $63.7M | 5.5M | $8.7M | 2.9M | +2.6M+89.51% | Add |
| D. E. Shaw & Co., Inc. |
| 0.03% | <0.01% | #46 | $60.7M | 5.2M | $1.9M | 649,817 | +4.6M+706.34% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #92 | $41.5M | 3.6M | $10.0M | 3.3M | +240,095+7.18% | Add |
| Woodline Partners LP |
| 0.1% | 0.04% | #28 | $31.3M | 2.7M | $9.9M | 3.3M | -599,494-18.17% | Reduce |
| Siren, L.L.C. |
| 0.58% | 0.15% | #10 | $28.7M | 2.5M | $5.4M | 1.8M | +674,764+37.49% | Add |
| BVF INC/IL |
| 0.7% | — | #8 | $27.4M | 2.4M | $0 | 0 | +2.4M | New Buy |
| Gem Investment Advisors, LLC |
| 15.43% | 7.18% | #1 | $25.2M | 2.2M | $7.6M | 2.2M | 00.00% | Unchanged |
| BAKER BROS. ADVISORS LP |
| 0.12% | 0.04% | #25 | $24.7M | 2.1M | $6.4M | 2.1M | 00.00% | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #97 | $23.1M | 2.0M | $4.0M | 1.3M | +668,959+50.41% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #101 | $20.1M | 1.7M | $1.8M | 591,712 | +1.1M+192.76% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #69 | $20.0M | 1.7M | $1.0M | 342,689 | +1.4M+403.07% | Add |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
| 0.08% | — | #30 | $18.6M | 1.6M | $0 | 0 | +1.6M | New Buy |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #102 | $17.3M | 1.5M | $353,000 | 117,563 | +1.4M+1,167.40% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #124 | $15.9M | 1.4M | $2.9M | 969,868 | +404,825+41.74% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #134 | $15.5M | 1.3M | $0 | 0 | +1.3M | New Buy |
| FRED ALGER MANAGEMENT, LLC |
| 0.05% | 0.02% | #37 | $13.6M | 1.2M | $3.5M | 1.2M | +11,653+1.00% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #98 | $13.5M | 1.2M | $3.3M | 1.1M | +81,731+7.54% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #103 | $13.2M | 1.1M | $4.8M | 1.6M | -460,965-28.81% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #107 | $12.9M | 1.1M | $3.1M | 1.0M | +88,407+8.64% | Add |
| Sumitomo Mitsui Trust Group, Inc. |
| 0.01% | <0.01% | #66 | $11.9M | 1.0M | $4.0M | 1.3M | -320,949-23.83% | Reduce |
| Amova Asset Management Americas, Inc. |
| 0.15% | 0.06% | #22 | $11.7M | 1.0M | $4.0M | 1.3M | -332,809-24.71% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #88 | $11.3M | 974,122 | $0 | 0 | +974,122 | New Buy |
| Casdin Capital, LLC |
| 0.56% | 0.22% | #11 | $11.3M | 973,260 | $2.9M | 973,260 | 00.00% | Unchanged |
| Parkman Healthcare Partners LLC |
| 1.06% | 0.58% | #5 | $10.4M | 894,374 | $5.6M | 1.9M | -970,432-52.04% | Reduce |
| Integral Health Asset Management, LLC |
| 0.37% | — | #15 | $9.3M | 800,000 | $0 | 0 | +800,000 | New Buy |
| LAZARD ASSET MANAGEMENT LLC |
| 0.01% | <0.01% | #61 | $9.1M | 781,692 | $1.6M | 530,130 | +251,562+47.45% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #83 | $8.8M | 756,541 | $2.1M | 699,439 | +57,102+8.16% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #110 | $7.0M | 600,174 | $1.8M | 600,445 | -271-0.05% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #152 | $6.6M | 565,999 | $1.5M | 487,193 | +78,806+16.18% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #145 | $6.3M | 544,933 | $330,360 | 110,120 | +434,813+394.85% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #132 | $6.3M | 543,076 | $1.8M | 599,423 | -56,347-9.40% | Reduce |
| GROUP ONE TRADING LLC |
| 0.01% | 0.01% | #65 | $6.1M | 524,747 | $3.4M | 1.1M | -607,241-53.64% | Reduce |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #71 | $5.8M | 502,407 | $3.7M | 1.2M | -716,645-58.79% | Reduce |
| Trexquant Investment LP |
| 0.03% | — | #44 | $5.6M | 481,555 | $0 | 0 | +481,555 | New Buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd |
| 0.35% | 0.12% | #16 | $5.5M | 478,520 | $1.6M | 541,182 | -62,662-11.58% | Reduce |
| Artia Global Partners LP |
| 0.99% | — | #6 | $5.4M | 464,444 | $0 | 0 | +464,444 | New Buy |
| ROYCE & ASSOCIATES LP |
| 0.04% | 0.02% | #41 | $5.2M | 445,777 | $2.2M | 735,353 | -289,576-39.38% | Reduce |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #125 | $4.7M | 405,085 | $1.1M | 366,808 | +38,277+10.44% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #130 | $4.5M | 386,832 | $1.0M | 337,844 | +48,988+14.50% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | <0.01% | #68 | $4.2M | 359,091 | $3.1M | 1.0M | -686,107-65.64% | Reduce |
| Ikarian Capital, LLC |
| 0.44% | — | #13 | $4.1M | 353,772 | $0 | 0 | +353,772 | New Buy |
