| BVF INC/IL |
| 7.97% | 9.5% | #1 | $311.5M | 16.0M | $298.3M | 16.0M | 00.00% | Unchanged |
| Deep Track Capital, LP |
| 1.98% | 1.95% | #12 | $136.3M | 7.0M | $119.5M | 6.4M | +590,162+9.21% | Add |
| T. Rowe Price Investment Management, Inc. |
| 0.05% | — | #41 | $83.3M | 4.3M | $0 | 0 | +4.3M | New Buy |
| D. E. Shaw & Co., Inc. |
| 0.03% | 0.03% | #48 | $65.5M | 3.4M | $44.6M | 2.4M | +974,846+40.78% | Add |
| Cormorant Asset Management, LP |
| 3.17% | 4.19% | #3 | $62.4M | 3.2M | $83.5M | 4.5M | -1.3M-28.46% | Reduce |
| Jupiter Topco LLC |
| 0.02% | — | #52 | $60.1M | 3.1M | $0 | 0 | +3.1M | New Buy |
| Logos Global Management LP |
| 2.24% | 1.4% | #10 | $52.1M | 2.7M | $28.0M | 1.5M | +1.2M+78.33% | Add |
| Weiss Asset Management LP |
| 0.53% | 0.54% | #17 | $50.3M | 2.6M | $31.8M | 1.7M | +873,485+51.13% | Add |
| CITADEL ADVISORS LLC |
| 0.01% | 0.01% | #80 | $47.9M | 2.5M | $38.8M | 2.1M | +376,065+18.07% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.02% | 0.02% | #54 | $33.4M | 1.7M | $20.9M | 1.1M | +593,037+52.84% | Add |
| MPM BioImpact LLC |
| 1.91% | 2.61% | #13 | $31.3M | 1.6M | $33.8M | 1.8M | -204,115-11.27% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #100 | $27.6M | 1.4M | $18.4M | 1.1M | +297,908+27.37% | Add |
| Vivo Capital, LLC |
| 2.49% | 1.55% | #6 | $27.3M | 1.4M | $18.6M | 1.0M | +400,000+40.00% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #96 | $22.8M | 1.2M | $10.7M | 572,525 | +596,961+104.27% | Add |
| Point72 Asset Management, L.P. |
| 0.02% | 0.03% | #51 | $22.6M | 1.2M | $25.5M | 1.4M | -209,786-15.33% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #128 | $21.3M | 1.1M | $19.0M | 1.0M | +72,940+7.14% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #94 | $20.3M | 1.0M | $24.1M | 1.3M | -253,334-19.56% | Reduce |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.03% | #56 | $17.8M | 912,715 | $19.9M | 1.1M | -152,895-14.35% | Reduce |
| GREAT POINT PARTNERS LLC |
| 3.15% | 2.14% | #4 | $16.7M | 855,813 | $9.3M | 500,000 | +355,813+71.16% | Add |
| Candriam S.C.A. |
| 0.07% | 0.01% | #38 | $15.0M | 769,766 | $1.8M | 134,329 | +635,437+473.05% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #108 | $14.6M | 751,897 | $13.5M | 724,794 | +27,103+3.74% | Add |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.01% | <0.01% | #76 | $14.6M | 750,777 | $1.3M | 70,140 | +680,637+970.40% | Add |
| Trails Edge Capital Partners, LP |
| 2.32% | — | #9 | $14.6M | 750,000 | $0 | 0 | +750,000 | New Buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #106 | $14.0M | 719,942 | $22.5M | 1.2M | -488,682-40.43% | Reduce |
| HRT FINANCIAL LP |
| 0.02% | 0.02% | #55 | $13.2M | 679,244 | $9.1M | 487,583 | +191,661+39.31% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.02% | 0.01% | #63 | $12.5M | 643,268 | $5.2M | 276,772 | +366,496+132.42% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #83 | $12.4M | 636,187 | $10.7M | 576,092 | +60,095+10.43% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #117 | $11.0M | 563,602 | $1.8M | 256,655 | +306,947+119.60% | Add |
| MARSHALL WACE, LLP |
| 0.01% | <0.01% | #73 | $10.7M | 550,351 | $2.1M | 111,331 | +439,020+394.34% | Add |
| Qube Research & Technologies Ltd |
| 0.01% | <0.01% | #72 | $9.7M | 496,242 | $799,973 | 42,917 | +453,325+1,056.28% | Add |
| Caption Management, LLC |
| 0.04% | — | #45 | $8.9M | 455,800 | $0 | 0 | +455,800 | New Buy |
| ALGERT GLOBAL LLC |
| 0.09% | 0.04% | #32 | $7.5M | 386,960 | $2.8M | 151,256 | +235,704+155.83% | Add |
| Rhenman & Partners Asset Management AB |
| 0.71% | 0.55% | #15 | $7.5M | 384,800 | $4.5M | 239,500 | +145,300+60.67% | Add |
| Trexquant Investment LP |
| 0.04% | 0.07% | #44 | $7.4M | 377,946 | $9.2M | 495,336 | -117,390-23.70% | Reduce |
| Capricorn Fund Managers Ltd |
| 0.58% | — | #16 | $7.3M | 374,866 | $0 | 0 | +374,866 | New Buy |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #87 | $7.0M | 358,884 | $860,889 | 46,185 | +312,699+677.06% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #86 | $6.6M | 341,537 | $4.5M | 239,838 | +101,699+42.40% | Add |
| Jump Financial, LLC |
| 0.05% | 0.08% | #42 | $6.5M | 336,243 | $6.1M | 325,968 | +10,275+3.15% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #112 | $6.4M | 328,522 | $72,304 | 3,879 | +324,643+8,369.24% | Add |
| J. Goldman & Co LP |
| 0.16% | 0.07% | #25 | $6.2M | 315,945 | $2.6M | 136,900 | +179,045+130.79% | Add |
| Granahan Investment Management, LLC |
| 0.22% | 0.2% | #20 | $6.1M | 313,884 | $4.1M | 220,600 | +93,284+42.29% | Add |
| Boxer Capital Management, LLC |
| 0.4% | 0.67% | #19 | $5.4M | 275,000 | $5.1M | 275,000 | 00.00% | Unchanged |
| Walleye Capital LLC |
| 0.02% | 0.03% | #62 | $5.0M | 256,169 | $7.0M | 377,672 | -121,503-32.17% | Reduce |
| Susquehanna Portfolio Strategies, LLC |
| 0.08% | 0.07% | #36 | $4.9M | 253,974 | $4.7M | 253,974 | 00.00% | Unchanged |
| Holocene Advisors, LP |
| 0.01% | 0.03% | #69 | $4.9M | 250,000 | $11.2M | 600,000 | -350,000-58.33% | Reduce |
| Burkehill Global Management, LP |
| 0.18% | — | #22 | $4.9M | 250,000 | $0 | 0 | +250,000 | New Buy |
| Y-Intercept (Hong Kong) Ltd |
| 0.08% | 0.04% | #34 | $4.2M | 215,849 | $2.4M | 127,087 | +88,762+69.84% | Add |
| ACUTA CAPITAL PARTNERS, LLC |
| 2.93% | 2.52% | #5 | $4.2M | 215,652 | $3.6M | 191,760 | +23,892+12.46% | Add |
| Verition Fund Management LLC |
| 0.01% | — | #81 | $4.0M | 207,102 | $0 | 0 | +207,102 | New Buy |
| HighVista Strategies LLC |
| 0.83% | 1% | #14 | $3.7M | 187,946 | $3.6M | 193,955 | -6,009-3.10% | Reduce |
