| BlackRock, Inc. |
| <0.01% | <0.01% | #90 | $115.3M | 10.5M | $78.4M | 9.6M | +871,702+9.04% | Add |
| MONTANOVA CAPITAL, LLC |
| 1.72% | 1.78% | #7 | $94.1M | 8.6M | $69.7M | 8.6M | 00.00% | Unchanged |
| BVF INC/IL |
| 2.37% | 2.19% | #5 | $92.7M | 8.4M | $68.7M | 8.4M | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #89 | $58.5M | 5.3M | $36.7M | 4.5M | +817,317+18.11% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #117 | $43.0M | 3.9M | $30.8M | 3.8M | +130,479+3.45% | Add |
| ARMISTICE CAPITAL, LLC |
| 0.49% | 0.54% | #15 | $40.3M | 3.7M | $30.4M | 3.7M | -58,000-1.55% | Reduce |
| AQR CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #50 | $34.3M | 3.1M | $17.3M | 2.1M | +1.0M+47.18% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #80 | $24.8M | 2.3M | $11.7M | 1.4M | +831,700+58.02% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #104 | $24.5M | 2.2M | $16.5M | 2.0M | +195,682+9.62% | Add |
| ALETHEA CAPITAL MANAGEMENT, LLC |
| 9.85% | 6.38% | #1 | $23.8M | 2.2M | $12.4M | 1.5M | +638,569+41.75% | Add |
| Prosight Management, LP |
| 3.82% | 4.48% | #2 | $22.2M | 2.0M | $27.3M | 3.4M | -1.3M-39.76% | Reduce |
| Deep Track Capital, LP |
| 0.32% | 0.35% | #19 | $21.7M | 2.0M | $21.5M | 2.6M | -664,977-25.15% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.03% | 0.02% | #40 | $18.3M | 1.7M | $12.9M | 1.6M | +81,197+5.13% | Add |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.01% | — | #57 | $15.5M | 1.4M | $0 | 0 | +1.4M | New Buy |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #128 | $14.6M | 1.3M | $10.0M | 1.2M | +99,139+8.05% | Add |
| NAN FUNG TRINITY (HK) Ltd |
| 1.27% | 0.95% | #9 | $12.9M | 1.2M | $8.7M | 1.1M | +110,000+10.33% | Add |
| Qube Research & Technologies Ltd |
| 0.01% | 0.01% | #51 | $12.8M | 1.2M | $13.3M | 1.6M | -466,849-28.52% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #78 | $12.8M | 1.2M | $11.6M | 1.4M | -256,756-18.01% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #123 | $12.7M | 1.2M | $10.0M | 1.2M | -69,210-5.63% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #126 | $12.7M | 1.2M | $16.0M | 1.8M | -652,754-36.00% | Reduce |
| Connor, Clark & Lunn Investment Management Ltd. |
| 0.02% | 0.01% | #42 | $10.9M | 996,114 | $6.5M | 800,597 | +195,517+24.42% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #102 | $10.6M | 964,636 | $8.5M | 1.0M | -75,597-7.27% | Reduce |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.04% | 0.02% | #34 | $10.4M | 948,974 | $4.9M | 602,231 | +346,743+57.58% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #111 | $9.1M | 831,160 | $6.1M | 756,273 | +74,887+9.90% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #75 | $7.8M | 711,332 | $12.7M | 1.6M | -853,811-54.55% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #114 | $7.4M | 676,400 | $5.6M | 690,817 | -14,417-2.09% | Reduce |
| Jump Financial, LLC |
| 0.06% | 0.05% | #29 | $7.4M | 675,044 | $4.1M | 505,452 | +169,592+33.55% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #96 | $6.9M | 629,560 | $4.5M | 554,983 | +74,577+13.44% | Add |
| Fisher Asset Management, LLC |
| <0.01% | <0.01% | #84 | $6.9M | 625,936 | $5.5M | 675,305 | -49,369-7.31% | Reduce |
| ROYCE & ASSOCIATES LP |
| 0.05% | — | #30 | $6.7M | 609,985 | $0 | 0 | +609,985 | New Buy |
| Rhenman & Partners Asset Management AB |
| 0.61% | 0.27% | #13 | $6.5M | 591,500 | $2.2M | 271,500 | +320,000+117.86% | Add |
| Hennion & Walsh Asset Management, Inc. |
| 0.18% | 0.09% | #24 | $6.2M | 568,845 | $2.7M | 335,212 | +233,633+69.70% | Add |
| JUPITER ASSET MANAGEMENT LTD |
| 0.03% | — | #39 | $5.6M | 509,886 | $0 | 0 | +509,886 | New Buy |
| 1492 Capital Management LLC |
| 1.51% | 1.5% | #8 | $5.1M | 467,153 | $4.0M | 486,123 | -18,970-3.90% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #132 | $4.8M | 441,605 | $4.0M | 497,125 | -55,520-11.17% | Reduce |
| SECTOR GAMMA AS |
| 1.03% | 0.79% | #10 | $4.8M | 433,012 | $3.3M | 411,810 | +21,202+5.15% | Add |
| Man Group plc |
| 0.01% | 0.01% | #56 | $4.7M | 432,908 | $3.9M | 475,027 | -42,119-8.87% | Reduce |
| FMR LLC |
| <0.01% | <0.01% | #171 | $4.0M | 363,342 | $2.6M | 317,652 | +45,690+14.38% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #157 | $3.9M | 359,076 | $2.5M | 305,392 | +53,684+17.58% | Add |
| IEQ CAPITAL, LLC |
| 0.02% | 0.01% | #45 | $3.8M | 348,125 | $2.3M | 281,904 | +66,221+23.49% | Add |
| Susquehanna Portfolio Strategies, LLC |
| 0.06% | 0.04% | #28 | $3.8M | 343,891 | $2.8M | 343,891 | 00.00% | Unchanged |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.42% | 0.38% | #17 | $3.2M | 295,039 | $2.4M | 295,522 | -483-0.16% | Reduce |
| OP Asset Management Ltd |
| 0.03% | — | #35 | $3.2M | 291,880 | $0 | 0 | +291,880 | New Buy |
| Ally Bridge Group (NY) LLC |
| 2.81% | — | #3 | $3.2M | 290,000 | $0 | 0 | +290,000 | New Buy |
| Ishara Investments LP |
| 2.19% | — | #6 | $3.0M | 276,750 | $0 | 0 | +276,750 | New Buy |
| PRUDENTIAL FINANCIAL INC |
| <0.01% | <0.01% | #71 | $2.9M | 267,950 | $335,606 | 41,280 | +226,670+549.10% | Add |
| Assenagon Asset Management S.A. |
| <0.01% | <0.01% | #67 | $2.9M | 267,748 | $2.8M | 339,712 | -71,964-21.18% | Reduce |
| GREAT LAKES ADVISORS, LLC |
| 0.02% | 0.02% | #41 | $2.9M | 259,857 | $2.8M | 339,599 | -79,742-23.48% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #143 | $2.8M | 257,767 | $2.1M | 254,325 | +3,442+1.35% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #176 | $2.7M | 245,920 | $406,382 | 52,572 | +193,348+367.78% | Add |
