| BAKER BROS. ADVISORS LP |
| 3.89% | 4.36% | #5 | $776.1M | 19.9M | $759.3M | 19.9M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #97 | $161.1M | 4.1M | $150.0M | 3.9M | +200,053+5.08% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.01% | #56 | $126.6M | 3.2M | $77.7M | 2.0M | +1.2M+59.30% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #91 | $94.3M | 2.4M | $85.8M | 2.3M | +168,497+7.49% | Add |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #62 | $90.2M | 2.3M | $66.3M | 1.7M | +577,011+33.18% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #110 | $70.3M | 1.8M | $65.5M | 1.7M | +87,556+5.10% | Add |
| BRAIDWELL LP |
| 2.58% | 2.31% | #8 | $69.6M | 1.8M | $69.3M | 1.8M | -31,347-1.72% | Reduce |
| Jupiter Topco LLC |
| 0.02% | — | #45 | $59.5M | 1.5M | $0 | 0 | +1.5M | New Buy |
| RTW INVESTMENTS, LP |
| 0.49% | 0.56% | #18 | $58.0M | 1.5M | $56.7M | 1.5M | 00.00% | Unchanged |
| Boxer Capital Management, LLC |
| 4.34% | 6.81% | #4 | $57.6M | 1.5M | $51.9M | 1.4M | +116,600+8.57% | Add |
| T. Rowe Price Investment Management, Inc. |
| 0.04% | 0.02% | #40 | $57.5M | 1.5M | $31.9M | 836,944 | +640,089+76.48% | Add |
| TCG Crossover Management, LLC |
| 1.35% | 1.58% | #12 | $56.3M | 1.4M | $55.1M | 1.4M | 00.00% | Unchanged |
| Ikarian Capital, LLC |
| 5.28% | 4.23% | #2 | $49.8M | 1.3M | $52.1M | 1.4M | -88,365-6.47% | Reduce |
| ICONIQ Capital, LLC |
| 1.42% | 1.08% | #11 | $49.3M | 1.3M | $48.3M | 1.3M | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #99 | $41.4M | 1.1M | $38.1M | 1.0M | +62,544+6.25% | Add |
| Artisan Partners Limited Partnership |
| 0.06% | 0.04% | #38 | $37.7M | 968,037 | $26.3M | 690,322 | +277,715+40.23% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.01% | <0.01% | #69 | $30.9M | 793,613 | $16.6M | 436,329 | +357,284+81.88% | Add |
| Board of Trustees of The Leland Stanford Junior University |
| 5.06% | 3.11% | #3 | $27.0M | 691,767 | $26.4M | 691,767 | 00.00% | Unchanged |
| DIADEMA PARTNERS LP |
| 2.7% | 2.85% | #7 | $21.9M | 561,717 | $16.8M | 440,062 | +121,655+27.64% | Add |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 2.21% | 3.86% | #9 | $21.3M | 546,256 | $37.8M | 991,930 | -445,674-44.93% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #125 | $20.8M | 532,819 | $13.9M | 365,051 | +167,768+45.96% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.03% | 0.03% | #43 | $19.5M | 500,000 | $21.9M | 575,000 | -75,000-13.04% | Reduce |
| Squadron Capital Management LLC |
| 6.05% | 5.31% | #1 | $19.5M | 500,000 | $14.5M | 380,000 | +120,000+31.58% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | <0.01% | #55 | $18.4M | 473,001 | $3.8M | 99,468 | +373,533+375.53% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #127 | $16.9M | 435,029 | $10.6M | 647,587 | -212,558-32.82% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #123 | $14.9M | 383,709 | $11.4M | 300,356 | +83,353+27.75% | Add |
| BOONE CAPITAL MANAGEMENT LLC |
| 3.44% | 3.29% | #6 | $14.7M | 378,010 | $10.7M | 281,332 | +96,678+34.36% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #106 | $14.3M | 366,827 | $14.9M | 391,349 | -24,522-6.27% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | 0.01% | #107 | $14.3M | 366,724 | $39.7M | 1.0M | -675,664-64.82% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #103 | $13.9M | 358,056 | $13.3M | 349,803 | +8,253+2.36% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #122 | $13.0M | 333,100 | $9.3M | 242,827 | +90,273+37.18% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.17% | 0.18% | #25 | $12.8M | 328,324 | $13.6M | 356,270 | -27,946-7.84% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #100 | $12.2M | 312,595 | $12.0M | 315,400 | -2,805-0.89% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #95 | $11.4M | 291,969 | $9.8M | 258,128 | +33,841+13.11% | Add |
| FMR LLC |
| <0.01% | <0.01% | #146 | $10.8M | 276,984 | $7.0M | 183,919 | +93,065+50.60% | Add |
| D. E. Shaw & Co., Inc. |
| <0.01% | 0.01% | #78 | $8.2M | 211,300 | $8.8M | 229,955 | -18,655-8.11% | Reduce |
| TD ASSET MANAGEMENT INC |
| 0.01% | 0.01% | #67 | $7.6M | 194,132 | $6.2M | 162,298 | +31,834+19.61% | Add |
| PFM Health Sciences, LP |
| 0.65% | 0.4% | #16 | $7.5M | 193,315 | $4.4M | 114,719 | +78,596+68.51% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #124 | $7.4M | 190,115 | $5.8M | 153,166 | +36,949+24.12% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.02% | #58 | $7.4M | 189,200 | $11.2M | 294,300 | -105,100-35.71% | Reduce |
| ALGERT GLOBAL LLC |
| 0.09% | 0.08% | #35 | $7.3M | 186,476 | $5.6M | 147,930 | +38,546+26.06% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #109 | $6.8M | 174,730 | $3.6M | 95,292 | +79,438+83.36% | Add |
| Squarepoint Ops LLC |
| 0.01% | <0.01% | #68 | $5.9M | 151,098 | $2.7M | 71,056 | +80,042+112.65% | Add |
| Ghisallo Capital Management LLC |
| 0.03% | — | #41 | $5.8M | 150,000 | $0 | 0 | +150,000 | New Buy |
| Bruce & Co., Inc. |
| 1.58% | 1.58% | #10 | $5.6M | 145,000 | $5.5M | 145,000 | 00.00% | Unchanged |
| FEDERATED HERMES, INC. |
| 0.01% | 0.01% | #61 | $5.6M | 144,065 | $8.0M | 210,210 | -66,145-31.47% | Reduce |
| PRUDENTIAL FINANCIAL INC |
| 0.01% | <0.01% | #71 | $4.7M | 120,495 | $3.1M | 80,215 | +40,280+50.22% | Add |
| Caption Management, LLC |
| 0.02% | <0.01% | #48 | $4.5M | 115,100 | $438,380 | 11,500 | +103,600+900.87% | Add |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | <0.01% | #83 | $4.4M | 114,089 | $4.6M | 120,629 | -6,540-5.42% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #133 | $4.4M | 111,935 | $4.2M | 111,341 | +594+0.53% | Add |
