| Stonepine Capital Management, LLC |
| 0.98% | 0.06% | #1 | $6.4M | 1.3M | $145,790 | 61,000 | +1.3M+2,106.43% | Add |
| Ikarian Capital, LLC |
| 0.07% | 0.01% | #2 | $649,267 | 135,830 | $109,992 | 45,830 | +90,000+196.38% | Add |
| ADAR1 Capital Management, LLC |
| 0.02% | — | #3 | $334,600 | 70,000 | $0 | 0 | +70,000 | New Buy |
| BOOTHBAY FUND MANAGEMENT, LLC |
| <0.01% | <0.01% | #4 | $64,645 | 13,524 | $32,322 | 13,524 | 00.00% | Unchanged |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #6 | $48,880 | 10,226 | $0 | 0 | +10,226 | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #9 | $33,427 | 6,993 | $0 | 0 | +6,993 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #8 | $6,983 | 1,461 | $1,742 | 729 | +732+100.41% | Add |
| Tower Research Capital LLC (TRC) |
| <0.01% | <0.01% | #5 | $3,819 | 799 | $3,131 | 1,310 | -511-39.01% | Reduce |
| BARCLAYS PLC |
| <0.01% | — | #10 | $91 | 19 | $0 | 0 | +19 | New Buy |
| BARRETT & COMPANY, INC. |
| <0.01% | <0.01% | #7 | $38 | 8 | $19 | 8 | 00.00% | Unchanged |
| DANSKE BANK A/S |
| <0.01% | <0.01% | #11 | $5 | 1 | $2 | 1 | 00.00% | Unchanged |
