| Lynx1 Capital Management LP |
| 0.75% | 0.56% | #1 | $3.8M | 875,328 | $3.6M | 875,328 | 00.00% | Unchanged |
| AdvisorShares Investments LLC |
| 0.13% | 0.12% | #2 | $1.1M | 252,909 | $632,344 | 155,367 | +97,542+62.78% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #16 | $758,143 | 173,488 | $0 | 0 | +173,488 | New Buy |
| Shay Capital LLC |
| 0.04% | 0.05% | #3 | $680,942 | 155,822 | $614,611 | 151,010 | +4,812+3.19% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | <0.01% | #10 | $621,536 | 142,228 | $578,685 | 142,183 | +45+0.03% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #14 | $317,083 | 72,559 | $78,677 | 19,331 | +53,228+275.35% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #17 | $216,384 | 49,516 | $211,668 | 52,007 | -2,491-4.79% | Reduce |
| Ikarian Capital, LLC |
| 0.02% | 0.02% | #5 | $207,326 | 47,443 | $193,093 | 47,443 | 00.00% | Unchanged |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #15 | $147,732 | 33,806 | $0 | 0 | +33,806 | New Buy |
| ADAR1 Capital Management, LLC |
| 0.01% | 0.01% | #7 | $131,100 | 30,000 | $122,100 | 30,000 | 00.00% | Unchanged |
| FNY Investment Advisers, LLC |
| 0.04% | 0.05% | #4 | $115,805 | 26,500 | $107,000 | 26,500 | 00.00% | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | — | #12 | $111,435 | 25,500 | $0 | 0 | +25,500 | New Buy |
| XTX Topco Ltd |
| <0.01% | — | #8 | $100,899 | 23,089 | $0 | 0 | +23,089 | New Buy |
| HRT FINANCIAL LP |
| <0.01% | — | #11 | $99,920 | 22,865 | $0 | 0 | +22,865 | New Buy |
| JANE STREET GROUP, LLC |
| <0.01% | — | #18 | $65,126 | 14,903 | $0 | 0 | +14,903 | New Buy |
| BOOTHBAY FUND MANAGEMENT, LLC |
| <0.01% | <0.01% | #9 | $61,180 | 14,000 | $56,980 | 14,000 | 00.00% | Unchanged |
| COMMONWEALTH EQUITY SERVICES, LLC |
| <0.01% | <0.01% | #13 | $49,040 | 11,222 | $45,670 | 11,222 | 00.00% | Unchanged |
| NORTHERN TRUST CORP |
| <0.01% | — | #19 | $46,366 | 10,610 | $0 | 0 | +10,610 | New Buy |
| Merck & Co., Inc. |
| 0.01% | 0.01% | #6 | $43,818 | 10,027 | $40,810 | 10,027 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #21 | $9,251 | 2,117 | $9,426 | 2,316 | -199-8.59% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #22 | $254 | 58 | $83 | 7 | +51+728.57% | Add |
| Caitong International Asset Management Co., Ltd |
| <0.01% | — | #20 | $13 | 3 | $0 | 0 | +3 | New Buy |
