| BlackRock, Inc. |
| <0.01% | <0.01% | #82 | $192.3M | 5.9M | $175.4M | 5.4M | +491,643+9.13% | Add |
| RTW INVESTMENTS, LP |
| 1.57% | 1.82% | #7 | $184.0M | 5.6M | $183.1M | 5.6M | 00.00% | Unchanged |
| FMR LLC |
| 0.01% | 0.01% | #61 | $173.8M | 5.3M | $175.3M | 5.4M | -70,566-1.31% | Reduce |
| Lynx1 Capital Management LP |
| 26.03% | 24.51% | #1 | $132.1M | 4.0M | $155.1M | 4.8M | -725,269-15.22% | Reduce |
| Redmile Group, LLC |
| 8.67% | 8.98% | #2 | $129.1M | 3.9M | $135.6M | 4.2M | -218,200-5.24% | Reduce |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.02% | 0.02% | #44 | $115.2M | 3.5M | $100.8M | 3.1M | +423,601+13.68% | Add |
| MORGAN STANLEY |
| 0.01% | 0.01% | #63 | $113.0M | 3.5M | $83.1M | 3.5M | -84,255-2.38% | Reduce |
| BAKER BROS. ADVISORS LP |
| 0.55% | 0.62% | #14 | $109.2M | 3.3M | $108.6M | 3.3M | 00.00% | Unchanged |
| TORONTO DOMINION BANK |
| 0.12% | 0.15% | #25 | $103.8M | 3.2M | $103.3M | 3.2M | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #83 | $93.3M | 2.9M | $74.1M | 2.3M | +575,728+25.29% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.01% | #59 | $87.1M | 2.7M | $63.0M | 1.9M | +727,568+37.62% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #98 | $84.6M | 2.6M | $76.7M | 2.4M | +231,334+9.82% | Add |
| BVF INC/IL |
| 2.13% | 2.64% | #4 | $83.4M | 2.5M | $82.9M | 2.5M | 00.00% | Unchanged |
| T. Rowe Price Investment Management, Inc. |
| 0.05% | 0.01% | #31 | $79.0M | 2.4M | $8.2M | 250,913 | +2.2M+862.54% | Add |
| Siren, L.L.C. |
| 1.32% | 1.8% | #9 | $65.3M | 2.0M | $65.0M | 2.0M | 00.00% | Unchanged |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.62% | 0.7% | #13 | $59.7M | 1.8M | $59.4M | 1.8M | 00.00% | Unchanged |
| Jupiter Topco LLC |
| 0.02% | — | #41 | $59.4M | 1.8M | $0 | 0 | +1.8M | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #84 | $49.9M | 1.5M | $43.1M | 1.3M | +202,049+15.28% | Add |
| Assenagon Asset Management S.A. |
| 0.05% | 0.04% | #32 | $36.9M | 1.1M | $29.5M | 907,015 | +221,373+24.41% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #62 | $33.2M | 1.0M | $32.2M | 989,936 | +23,975+2.42% | Add |
| Polar Capital Holdings Plc |
| 0.06% | 0.13% | #29 | $27.3M | 833,716 | $36.9M | 1.1M | -298,795-26.38% | Reduce |
| EcoR1 Capital, LLC |
| 1.17% | 0.14% | #11 | $24.0M | 735,000 | $3.3M | 100,000 | +635,000+635.00% | Add |
| MPM BioImpact LLC |
| 1.44% | 1.93% | #8 | $23.7M | 723,314 | $25.0M | 767,038 | -43,724-5.70% | Reduce |
| Opaleye Management Inc. |
| 2.07% | 3% | #5 | $22.9M | 700,000 | $22.8M | 700,000 | 00.00% | Unchanged |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #101 | $18.8M | 575,344 | $27.0M | 830,702 | -255,358-30.74% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #126 | $18.6M | 566,993 | $15.1M | 462,682 | +104,311+22.54% | Add |
| BAILLIE GIFFORD & CO |
| 0.02% | 0.02% | #51 | $16.9M | 517,275 | $18.7M | 575,182 | -57,907-10.07% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #93 | $16.4M | 500,124 | $14.1M | 431,630 | +68,494+15.87% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #96 | $16.3M | 499,301 | $5.8M | 179,422 | +319,879+178.28% | Add |
| Troluce Capital Advisors LLC |
| 1.67% | 1.3% | #6 | $16.2M | 496,416 | $21.3M | 652,800 | -156,384-23.96% | Reduce |
| FIRST TRUST ADVISORS LP |
| 0.01% | <0.01% | #58 | $16.1M | 490,913 | $5.3M | 163,459 | +327,454+200.33% | Add |
| Candriam S.C.A. |
| 0.07% | 0.07% | #28 | $15.7M | 480,136 | $14.2M | 446,690 | +33,446+7.49% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #89 | $15.3M | 467,012 | $14.2M | 437,175 | +29,837+6.82% | Add |
| Granahan Investment Management, LLC |
| 0.54% | 0.53% | #15 | $15.1M | 461,608 | $10.9M | 335,586 | +126,022+37.55% | Add |
| Erste Asset Management GmbH |
| 0.11% | 0.13% | #26 | $13.9M | 428,381 | $14.2M | 446,000 | -17,619-3.95% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #79 | $13.2M | 402,503 | $11.6M | 356,947 | +45,556+12.76% | Add |
| Parkman Healthcare Partners LLC |
| 1.19% | 1.13% | #10 | $11.6M | 355,443 | $11.0M | 336,519 | +18,924+5.62% | Add |
| Artisan Partners Limited Partnership |
| 0.02% | 0.02% | #47 | $11.6M | 355,153 | $10.3M | 315,492 | +39,661+12.57% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #121 | $10.9M | 331,701 | $2.8M | 86,449 | +245,252+283.70% | Add |
| TANG CAPITAL MANAGEMENT LLC |
| 0.45% | 0.83% | #17 | $9.8M | 300,000 | $16.3M | 500,000 | -200,000-40.00% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #81 | $8.5M | 261,028 | $16.7M | 512,141 | -251,113-49.03% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #138 | $8.5M | 259,708 | $17.7M | 543,095 | -283,387-52.18% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #143 | $8.5M | 259,352 | $8.4M | 265,473 | -6,121-2.31% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #123 | $6.8M | 207,112 | $5.2M | 158,304 | +48,808+30.83% | Add |
| Birchview Capital, LP |
| 2.63% | 3.89% | #3 | $5.8M | 178,110 | $6.8M | 210,000 | -31,890-15.19% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #122 | $5.4M | 164,273 | $4.7M | 143,407 | +20,866+14.55% | Add |
| NORGES BANK |
| <0.01% | — | #139 | $5.3M | 163,200 | $0 | 0 | +163,200 | New Buy |
| FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #116 | $4.8M | 146,395 | $4.6M | 142,793 | +3,602+2.52% | Add |
| DAFNA Capital Management LLC |
| 0.82% | 0.97% | #12 | $4.3M | 130,875 | $4.3M | 130,875 | 00.00% | Unchanged |
| ExodusPoint Capital Management, LP |
| 0.03% | — | #40 | $4.2M | 129,660 | $0 | 0 | +129,660 | New Buy |
