| WELLINGTON MANAGEMENT GROUP LLP |
| 0.03% | 0.03% | #42 | $181.7M | 5.7M | $141.9M | 4.7M | +1.0M+21.58% | Add |
| RTW INVESTMENTS, LP |
| 1.32% | 1.46% | #9 | $154.6M | 4.9M | $146.8M | 4.9M | 00.00% | Unchanged |
| FMR LLC |
| 0.01% | 0.01% | #70 | $136.8M | 4.3M | $145.6M | 4.8M | -521,908-10.81% | Reduce |
| PRIMECAP MANAGEMENT CO/CA/ |
| 0.07% | 0.09% | #31 | $115.5M | 3.6M | $111.4M | 3.7M | -55,000-1.49% | Reduce |
| Bellevue Group AG |
| 1.86% | 2.01% | #6 | $88.5M | 2.8M | $84.3M | 2.8M | -8,558-0.31% | Reduce |
| TANG CAPITAL MANAGEMENT LLC |
| 3.82% | 4.06% | #2 | $84.1M | 2.6M | $79.9M | 2.6M | 00.00% | Unchanged |
| Vestal Point Capital, LP |
| 1.34% | 2.33% | #8 | $57.2M | 1.8M | $83.4M | 2.8M | -966,868-34.94% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| 0.04% | 0.02% | #39 | $52.4M | 1.6M | $30.8M | 1.0M | +627,718+61.46% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.02% | 0.02% | #50 | $50.7M | 1.6M | $37.3M | 1.2M | +359,634+29.06% | Add |
| ARMISTICE CAPITAL, LLC |
| 0.55% | 0.64% | #17 | $45.3M | 1.4M | $35.8M | 1.2M | +240,000+20.20% | Add |
| Caligan Partners LP |
| 2.06% | — | #5 | $43.9M | 1.4M | $0 | 0 | +1.4M | New Buy |
| Kynam Capital Management, LP |
| 2.41% | 1.65% | #4 | $43.7M | 1.4M | $26.7M | 884,937 | +490,063+55.38% | Add |
| BVF INC/IL |
| 1.05% | 1.24% | #10 | $41.1M | 1.3M | $39.0M | 1.3M | 00.00% | Unchanged |
| ACADIAN ASSET MANAGEMENT LLC |
| 0.05% | 0.02% | #36 | $38.4M | 1.2M | $15.1M | 501,091 | +708,803+141.45% | Add |
| Trails Edge Capital Partners, LP |
| 5.36% | 4.71% | #1 | $33.8M | 1.1M | $20.6M | 682,597 | +380,637+55.76% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #98 | $31.9M | 1.0M | $19.8M | 656,309 | +348,289+53.07% | Add |
| Point72 Asset Management, L.P. |
| 0.03% | 0.04% | #40 | $31.4M | 990,280 | $33.2M | 1.1M | -111,991-10.16% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #79 | $26.4M | 831,068 | $27.7M | 919,332 | -88,264-9.60% | Reduce |
| Jupiter Topco LLC |
| 0.01% | — | #58 | $22.5M | 709,022 | $0 | 0 | +709,022 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #80 | $20.7M | 651,961 | $7.2M | 240,299 | +411,662+171.31% | Add |
| Logos Global Management LP |
| 0.82% | 2.26% | #13 | $19.1M | 600,000 | $45.2M | 1.5M | -900,000-60.00% | Reduce |
| MARSHALL WACE, LLP |
| 0.01% | 0.01% | #54 | $18.8M | 590,941 | $5.4M | 180,340 | +410,601+227.68% | Add |
| Hudson Bay Capital Management LP |
| 0.05% | 0.07% | #34 | $18.7M | 590,000 | $19.1M | 633,174 | -43,174-6.82% | Reduce |
| BRAIDWELL LP |
| 0.61% | — | #16 | $16.6M | 521,327 | $0 | 0 | +521,327 | New Buy |
| Jones Hill Capital LP |
| 3.46% | — | #3 | $16.3M | 512,856 | $0 | 0 | +512,856 | New Buy |
| PRINCIPAL FINANCIAL GROUP INC |
| 0.01% | 0.01% | #61 | $15.4M | 485,789 | $15.7M | 519,130 | -33,341-6.42% | Reduce |
| Frazier Life Sciences Management, L.P. |
| 0.34% | 0.38% | #18 | $15.4M | 484,782 | $14.6M | 484,782 | 00.00% | Unchanged |
| Fulcrum Asset Management LLP |
| 1.43% | — | #7 | $14.3M | 470,025 | $0 | 0 | +470,025 | New Buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| <0.01% | <0.01% | #73 | $12.9M | 407,219 | $12.3M | 407,373 | -154-0.04% | Reduce |
| Caption Management, LLC |
| 0.06% | 0.34% | #32 | $12.9M | 405,603 | $58.3M | 1.9M | -1.5M-79.03% | Reduce |
| D. E. Shaw & Co., Inc. |
| 0.01% | 0.01% | #68 | $12.9M | 405,116 | $10.1M | 335,191 | +69,925+20.86% | Add |
| Candriam S.C.A. |
| 0.05% | 0.05% | #33 | $11.8M | 373,046 | $9.4M | 269,729 | +103,317+38.30% | Add |
| CANTOR FITZGERALD, L. P. |
| 0.12% | 0.13% | #28 | $10.8M | 340,100 | $9.1M | 300,711 | +39,389+13.10% | Add |
| Woodline Partners LP |
| 0.03% | 0.04% | #43 | $10.1M | 316,762 | $9.6M | 316,762 | 00.00% | Unchanged |
| Deep Track Capital, LP |
| 0.14% | 0.95% | #25 | $9.9M | 311,218 | $58.2M | 1.9M | -1.6M-83.89% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #93 | $9.6M | 303,448 | $18.0M | 596,268 | -292,820-49.11% | Reduce |
| Legal & General Group Plc |
| <0.01% | <0.01% | #83 | $9.5M | 299,670 | $4.7M | 156,143 | +143,527+91.92% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.13% | — | #27 | $9.4M | 295,546 | $0 | 0 | +295,546 | New Buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #95 | $9.0M | 284,870 | $1.0M | 34,122 | +250,748+734.86% | Add |
| MOORE CAPITAL MANAGEMENT, LP |
| 0.13% | 0.12% | #26 | $8.7M | 274,663 | $5.9M | 197,308 | +77,355+39.21% | Add |
| DIADEMA PARTNERS LP |
| 1% | 0.99% | #11 | $8.1M | 254,863 | $5.8M | 193,189 | +61,674+31.92% | Add |
| Qube Research & Technologies Ltd |
| 0.01% | — | #65 | $7.1M | 223,124 | $0 | 0 | +223,124 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #104 | $6.0M | 187,850 | $9.8M | 269,204 | -81,354-30.22% | Reduce |
| Catalio Capital Management, LP |
| 0.88% | 0.53% | #12 | $4.7M | 148,045 | $2.5M | 84,352 | +63,693+75.51% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #101 | $4.4M | 137,326 | $3.6M | 119,497 | +17,829+14.92% | Add |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| <0.01% | — | #84 | $4.3M | 134,165 | $0 | 0 | +134,165 | New Buy |
| Jump Financial, LLC |
| 0.03% | 0.02% | #41 | $4.2M | 131,949 | $1.2M | 38,498 | +93,451+242.74% | Add |
| Y-Intercept (Hong Kong) Ltd |
| 0.08% | 0.02% | #29 | $4.0M | 126,652 | $1.1M | 34,927 | +91,725+262.62% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #107 | $3.7M | 116,144 | $6.2M | 206,866 | -90,722-43.86% | Reduce |
| XTX Topco Ltd |
| 0.05% | 0.05% | #35 | $3.7M | 116,135 | $2.9M | 96,106 | +20,029+20.84% | Add |
