| Avoro Capital Advisors LLC |
| 1.46% | 0.95% | #10 | $162.7M | 23.9M | $97.0M | 21.7M | +2.2M+10.09% | Add |
| RA CAPITAL MANAGEMENT, L.P. |
| 1.39% | 1.12% | #12 | $160.4M | 23.6M | $105.3M | 23.6M | 00.00% | Unchanged |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #58 | $154.7M | 22.7M | $100.0M | 22.4M | +343,473+1.54% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #92 | $140.9M | 20.7M | $82.1M | 18.4M | +2.3M+12.67% | Add |
| Vestal Point Capital, LP |
| 3.09% | 2.25% | #3 | $132.2M | 19.4M | $80.5M | 18.0M | +1.4M+7.86% | Add |
| MORGAN STANLEY |
| 0.01% | <0.01% | #68 | $112.3M | 16.5M | $63.1M | 19.3M | -2.8M-14.61% | Reduce |
| RTW INVESTMENTS, LP |
| 0.79% | 0.61% | #18 | $92.3M | 13.6M | $61.2M | 13.7M | -119,990-0.88% | Reduce |
| FMR LLC |
| <0.01% | <0.01% | #75 | $90.8M | 13.3M | $64.0M | 14.3M | -984,842-6.88% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #95 | $85.0M | 12.5M | $45.7M | 10.2M | +2.2M+21.96% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #88 | $77.8M | 11.4M | $50.1M | 11.2M | +212,842+1.90% | Add |
| Siren, L.L.C. |
| 1.36% | 1.09% | #14 | $67.1M | 9.8M | $39.5M | 8.8M | +1.0M+11.51% | Add |
| Octagon Capital Advisors LP |
| 5.93% | 4.38% | #1 | $66.0M | 9.7M | $39.6M | 8.9M | +833,333+9.41% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #87 | $44.7M | 6.6M | $24.7M | 5.5M | +1.0M+18.59% | Add |
| Polar Capital Holdings Plc |
| 0.08% | 0.09% | #37 | $34.8M | 5.1M | $25.3M | 5.7M | -537,207-9.50% | Reduce |
| MPM BioImpact LLC |
| 1.87% | — | #8 | $30.6M | 4.5M | $0 | 0 | +4.5M | New Buy |
| D. E. Shaw & Co., Inc. |
| 0.01% | 0.01% | #57 | $30.0M | 4.4M | $19.8M | 4.4M | -28,649-0.65% | Reduce |
| BAKER BROS. ADVISORS LP |
| 0.14% | 0.1% | #33 | $27.3M | 4.0M | $17.9M | 4.0M | 00.00% | Unchanged |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #71 | $27.1M | 4.0M | $2.8M | 626,361 | +3.3M+534.71% | Add |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND |
| 0.04% | 0.02% | #41 | $26.5M | 3.9M | $12.9M | 2.9M | +1.0M+34.76% | Add |
| Casdin Capital, LLC |
| 1.11% | 1.1% | #15 | $22.1M | 3.3M | $14.5M | 3.3M | 00.00% | Unchanged |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #117 | $21.4M | 3.1M | $9.0M | 2.0M | +1.1M+55.25% | Add |
| ADAR1 Capital Management, LLC |
| 0.95% | 0.78% | #16 | $20.7M | 3.0M | $13.3M | 3.0M | +61,037+2.05% | Add |
| Pictet Asset Management Holding SA |
| 0.02% | <0.01% | #51 | $18.9M | 2.8M | $86,351 | 19,318 | +2.8M+14,242.59% | Add |
| Aberdeen Group plc |
| 0.02% | 0.01% | #49 | $15.8M | 2.3M | $4.6M | 1.0M | +1.3M+127.91% | Add |
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 0.07% | — | #38 | $15.3M | 2.3M | $0 | 0 | +2.3M | New Buy |
| NORGES BANK |
| <0.01% | — | #101 | $15.2M | 2.2M | $0 | 0 | +2.2M | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #96 | $15.2M | 2.2M | $8.1M | 1.8M | +411,892+22.70% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #93 | $15.0M | 2.2M | $8.1M | 1.8M | +392,096+21.68% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #70 | $14.5M | 2.1M | $14.7M | 3.3M | -1.2M-35.19% | Reduce |
| ORBIMED ADVISORS LLC |
| 0.26% | — | #27 | $13.6M | 2.0M | $0 | 0 | +2.0M | New Buy |
| RICE HALL JAMES & ASSOCIATES, LLC |
| 0.66% | 0.48% | #19 | $13.6M | 2.0M | $8.7M | 1.9M | +47,558+2.45% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #82 | $12.9M | 1.9M | $6.8M | 1.5M | +366,013+23.92% | Add |
| B Group, Inc. |
| 5.76% | 5.97% | #2 | $12.3M | 1.8M | $8.0M | 1.8M | 00.00% | Unchanged |
| Affinity Asset Advisors, LLC |
| 0.54% | 0.23% | #20 | $11.9M | 1.8M | $4.5M | 1.0M | +750,000+75.00% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #105 | $11.7M | 1.7M | $2.3M | 506,835 | +1.2M+238.02% | Add |
| BARCLAYS PLC |
| <0.01% | <0.01% | #90 | $11.1M | 1.6M | $11.4M | 2.8M | -1.2M-42.01% | Reduce |
| HEIGHTS CAPITAL MANAGEMENT, INC |
| 2.36% | — | #5 | $10.2M | 1.5M | $0 | 0 | +1.5M | New Buy |
| Seven Fleet Capital Management LP |
| 1.64% | 0.89% | #9 | $9.9M | 1.5M | $2.8M | 625,708 | +878,692+140.43% | Add |
| Palo Alto Investors LP |
| 1.38% | 0.95% | #13 | $9.5M | 1.4M | $6.2M | 1.4M | 00.00% | Unchanged |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #134 | $9.3M | 1.4M | $7.5M | 1.7M | -304,201-18.14% | Reduce |
| Granahan Investment Management, LLC |
| 0.32% | 0.19% | #24 | $8.9M | 1.3M | $3.9M | 883,241 | +421,936+47.77% | Add |
| Quantum Private Wealth, LLC |
| 1.42% | 1.17% | #11 | $5.5M | 812,027 | $3.8M | 849,212 | -37,185-4.38% | Reduce |
| FIRST TRUST ADVISORS LP |
| <0.01% | — | #80 | $5.4M | 791,169 | $0 | 0 | +791,169 | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #156 | $5.2M | 766,282 | $3.1M | 754,782 | +11,500+1.52% | Add |
| GordonMD Global Investments LP |
| 2% | 15.47% | #7 | $5.1M | 723,185 | $22.2M | 737,550 | -14,365-1.95% | Reduce |
| Sands Capital Alternatives, LLC |
| 0.8% | 0.77% | #17 | $4.9M | 724,873 | $3.2M | 724,873 | 00.00% | Unchanged |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #124 | $4.8M | 697,971 | $2.7M | 608,123 | +89,848+14.77% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #149 | $4.6M | 682,564 | $1.1M | 245,097 | +437,467+178.49% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #91 | $4.4M | 640,035 | $537,294 | 120,200 | +519,835+432.48% | Add |
| PANAGORA ASSET MANAGEMENT INC |
| 0.01% | <0.01% | #59 | $4.0M | 590,387 | $814,273 | 182,164 | +408,223+224.10% | Add |
