| NEA Management Company, LLC |
| 15.53% | 8.97% | #1 | $246.6M | 13.2M | $157.7M | 13.2M | 00.00% | Unchanged |
| FMR LLC |
| 0.01% | 0.01% | #86 | $234.3M | 12.6M | $95.9M | 8.0M | +4.5M+56.29% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #109 | $208.0M | 11.2M | $122.2M | 10.2M | +914,840+8.93% | Add |
| Frazier Life Sciences Management, L.P. |
| 4.04% | 3.05% | #9 | $185.4M | 9.9M | $118.6M | 9.9M | -100-0.00% | Reduce |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.02% | 0.01% | #77 | $106.0M | 5.7M | $61.9M | 5.2M | +495,504+9.55% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #118 | $103.1M | 5.5M | $59.4M | 5.0M | +552,108+11.09% | Add |
| Vivo Capital, LLC |
| 8.68% | 5.05% | #4 | $95.0M | 5.1M | $60.8M | 5.1M | 00.00% | Unchanged |
| Woodline Partners LP |
| 0.24% | 0.05% | #40 | $76.1M | 4.1M | $11.9M | 1.0M | +3.1M+307.81% | Add |
| Vestal Point Capital, LP |
| 1.35% | 0.72% | #16 | $57.8M | 3.1M | $25.8M | 2.2M | +933,496+43.09% | Add |
| MPM BioImpact LLC |
| 3.5% | 3.04% | #10 | $57.3M | 3.1M | $39.4M | 3.3M | -224,853-6.82% | Reduce |
| FRONTIER CAPITAL MANAGEMENT CO LLC |
| 0.53% | 0.24% | #26 | $57.3M | 3.1M | $23.8M | 2.0M | +1.1M+53.98% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #130 | $56.5M | 3.0M | $31.8M | 2.7M | +362,002+13.58% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #110 | $54.6M | 2.9M | $33.2M | 2.8M | +149,837+5.39% | Add |
| MARSHALL WACE, LLP |
| 0.04% | 0.05% | #64 | $49.9M | 2.7M | $47.3M | 4.0M | -1.3M-32.57% | Reduce |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 0.66% | 0.52% | #24 | $49.6M | 2.7M | $31.3M | 2.6M | +37,694+1.44% | Add |
| Rubric Capital Management LP |
| 0.43% | 0.47% | #32 | $46.7M | 2.5M | $44.3M | 3.7M | -1.2M-32.54% | Reduce |
| Artia Global Partners LP |
| 7.61% | 4.81% | #5 | $41.2M | 2.2M | $24.0M | 2.0M | +197,250+9.80% | Add |
| ACORN CAPITAL ADVISORS, LLC |
| 10.92% | 7.27% | #2 | $40.0M | 2.1M | $25.6M | 2.1M | 00.00% | Unchanged |
| First Light Asset Management, LLC |
| 2.38% | — | #12 | $39.1M | 2.1M | $0 | 0 | +2.1M | New Buy |
| Pictet Asset Management Holding SA |
| 0.04% | 0.02% | #66 | $37.6M | 2.0M | $20.4M | 1.7M | +307,738+18.04% | Add |
| Logos Global Management LP |
| 1.51% | 1.43% | #15 | $35.1M | 1.9M | $28.6M | 2.4M | -520,000-21.67% | Reduce |
| Affinity Asset Advisors, LLC |
| 1.52% | 1.23% | #14 | $33.6M | 1.8M | $23.9M | 2.0M | -200,000-10.00% | Reduce |
| EMERALD ADVISERS, LLC |
| 0.79% | 0.69% | #21 | $33.5M | 1.8M | $21.9M | 1.8M | -41,955-2.28% | Reduce |
| Siren, L.L.C. |
| 0.67% | 0.59% | #23 | $33.3M | 1.8M | $21.3M | 1.8M | 00.00% | Unchanged |
| Pivotal bioVenture Partners Investment Advisor LLC |
| 10.56% | 6.63% | #3 | $32.5M | 1.7M | $18.5M | 1.6M | +188,946+12.16% | Add |
| RAYMOND JAMES FINANCIAL INC |
| 0.01% | 0.01% | #89 | $30.4M | 1.7M | $20.9M | 1.8M | -127,320-7.12% | Reduce |
| VIKING GLOBAL INVESTORS LP |
| 0.08% | 0.11% | #55 | $28.8M | 1.5M | $38.2M | 3.2M | -1.7M-51.71% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #127 | $28.6M | 1.5M | $14.5M | 1.2M | +315,934+25.96% | Add |
| Assenagon Asset Management S.A. |
| 0.04% | — | #67 | $28.4M | 1.5M | $0 | 0 | +1.5M | New Buy |
| ALLIANCEBERNSTEIN L.P. |
| 0.01% | 0.01% | #87 | $28.1M | 2.4M | $35.6M | 2.8M | -490,019-17.22% | Reduce |
| ORBIMED ADVISORS LLC |
| 0.5% | 0.58% | #29 | $26.7M | 1.4M | $29.3M | 2.5M | -1.0M-41.73% | Reduce |
| Jones Hill Capital LP |
| 5.31% | 0.95% | #8 | $25.0M | 1.3M | $4.4M | 370,175 | +969,037+261.78% | Add |
| NAN FUNG TRINITY (HK) Ltd |
| 2.23% | 1.5% | #13 | $22.6M | 1.2M | $13.6M | 1.1M | +70,670+6.18% | Add |
| EMERALD MUTUAL FUND ADVISERS TRUST |
| 0.79% | 0.73% | #20 | $22.6M | 1.2M | $15.1M | 1.3M | -51,527-4.08% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #122 | $22.4M | 1.2M | $14.6M | 1.2M | -25,252-2.06% | Reduce |
| Jupiter Topco LLC |
| 0.01% | — | #88 | $22.2M | 1.2M | $0 | 0 | +1.2M | New Buy |
| Soleus Capital Management, L.P. |
| 0.76% | 0.78% | #22 | $22.0M | 1.2M | $19.3M | 1.6M | -440,382-27.18% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #145 | $21.9M | 1.2M | $11.6M | 968,588 | +208,284+21.50% | Add |
| BARCLAYS PLC |
| <0.01% | <0.01% | #102 | $21.3M | 1.1M | $639,268 | 53,585 | +1.1M+2,031.34% | Add |
| Saturn V Capital Management LP |
| 2.81% | — | #11 | $19.6M | 1.1M | $0 | 0 | +1.1M | New Buy |
| FLPUTNAM INVESTMENT MANAGEMENT CO |
| 0.23% | 0.19% | #41 | $19.4M | 1.0M | $12.7M | 1.1M | -25,244-2.37% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #119 | $18.8M | 1.0M | $9.6M | 806,659 | +199,379+24.72% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #132 | $18.6M | 995,950 | $6.8M | 566,088 | +429,862+75.94% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #116 | $18.0M | 965,402 | $10.0M | 840,572 | +124,830+14.85% | Add |
| Candriam S.C.A. |
| 0.08% | — | #56 | $18.0M | 966,219 | $0 | 0 | +966,219 | New Buy |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.01% | #76 | $15.8M | 845,087 | $5.7M | 473,849 | +371,238+78.35% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #105 | $15.7M | 841,059 | $8.5M | 714,631 | +126,428+17.69% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #151 | $14.9M | 800,465 | $39.4M | 4.3M | -3.5M-81.39% | Reduce |
| Nuveen, LLC |
| <0.01% | <0.01% | #106 | $14.3M | 765,176 | $2.2M | 188,182 | +576,994+306.61% | Add |
| Burkehill Global Management, LP |
| 0.49% | 0.31% | #30 | $13.5M | 725,000 | $6.3M | 525,000 | +200,000+38.10% | Add |
