| MONTANOVA CAPITAL, LLC |
| 9.37% | 6.72% | #3 | $512.5M | 4.2M | $263.3M | 4.2M | 00.00% | Unchanged |
| FMR LLC |
| 0.02% | 0.01% | #55 | $394.0M | 3.2M | $113.2M | 1.8M | +1.4M+78.76% | Add |
| SR ONE CAPITAL MANAGEMENT, LP |
| 28.42% | 16.57% | #1 | $295.3M | 2.4M | $151.7M | 2.4M | 00.00% | Unchanged |
| Deep Track Capital, LP |
| 3.58% | 0.52% | #6 | $245.9M | 2.0M | $31.6M | 500,000 | +1.5M+300.00% | Add |
| CITADEL ADVISORS LLC |
| 0.03% | 0.02% | #45 | $230.9M | 1.9M | $115.3M | 1.8M | +52,103+2.85% | Add |
| Siren, L.L.C. |
| 4.12% | 2.64% | #5 | $203.5M | 1.7M | $95.1M | 1.5M | +150,000+9.96% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #84 | $195.9M | 1.6M | $17.8M | 282,611 | +1.3M+463.95% | Add |
| VIKING GLOBAL INVESTORS LP |
| 0.55% | 0.3% | #20 | $192.0M | 1.6M | $106.8M | 1.7M | -129,061-7.63% | Reduce |
| JPMORGAN CHASE & CO |
| 0.01% | <0.01% | #65 | $144.2M | 1.2M | $59.4M | 976,166 | +189,418+19.40% | Add |
| Aberdeen Group plc |
| 0.19% | 0.11% | #26 | $134.8M | 1.1M | $66.6M | 1.1M | +41,982+3.98% | Add |
| D. E. Shaw & Co., Inc. |
| 0.06% | 0.01% | #37 | $124.6M | 1.0M | $8.5M | 134,219 | +879,424+655.22% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #92 | $106.9M | 869,212 | $44.2M | 699,645 | +169,567+24.24% | Add |
| MAVERICK CAPITAL LTD |
| 0.86% | — | #15 | $97.1M | 789,980 | $0 | 0 | +789,980 | New Buy |
| JENNISON ASSOCIATES LLC |
| 0.06% | 0.01% | #39 | $92.0M | 748,678 | $9.0M | 141,781 | +606,897+428.05% | Add |
| INFINITUM ASSET MANAGEMENT, LLC |
| 9.14% | 5.77% | #4 | $89.9M | 731,149 | $46.2M | 731,149 | 00.00% | Unchanged |
| UBS Group AG |
| 0.01% | <0.01% | #62 | $82.5M | 670,727 | $21.9M | 347,075 | +323,652+93.25% | Add |
| MARSHALL WACE, LLP |
| 0.06% | 0.04% | #38 | $72.0M | 585,560 | $41.3M | 654,601 | -69,041-10.55% | Reduce |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.09% | 0.11% | #36 | $67.6M | 549,706 | $69.5M | 1.1M | -550,294-50.03% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #98 | $66.9M | 544,369 | $4.7M | 74,400 | +469,969+631.68% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #82 | $62.5M | 508,067 | $11.3M | 178,206 | +329,861+185.10% | Add |
| Woodline Partners LP |
| 0.19% | 0.12% | #25 | $61.7M | 501,590 | $31.6M | 500,646 | +944+0.19% | Add |
| Bank of New York Mellon Corp |
| 0.01% | <0.01% | #69 | $42.6M | 346,585 | $231,634 | 3,668 | +342,917+9,348.88% | Add |
| STIFEL FINANCIAL CORP |
| 0.03% | 0.02% | #42 | $36.2M | 294,117 | $18.6M | 294,117 | 00.00% | Unchanged |
| EMERALD ADVISERS, LLC |
| 0.83% | 0.26% | #16 | $35.5M | 288,370 | $8.4M | 132,536 | +155,834+117.58% | Add |
| FRONTIER CAPITAL MANAGEMENT CO LLC |
| 0.29% | — | #22 | $31.3M | 254,876 | $0 | 0 | +254,876 | New Buy |
| BAMCO INC /NY/ |
| 0.04% | 0.01% | #41 | $28.2M | 229,581 | $3.8M | 59,668 | +169,913+284.76% | Add |
| EMERALD MUTUAL FUND ADVISERS TRUST |
| 0.91% | 0.33% | #14 | $25.8M | 209,924 | $6.9M | 109,283 | +100,641+92.09% | Add |
| Logos Global Management LP |
| 0.95% | 0.08% | #12 | $22.1M | 180,000 | $1.6M | 25,000 | +155,000+620.00% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #90 | $21.9M | 178,112 | $2.2M | 34,537 | +143,575+415.71% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #86 | $21.2M | 172,201 | $6.2M | 98,009 | +74,192+75.70% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.03% | 0.04% | #47 | $20.8M | 168,934 | $33.7M | 532,906 | -363,972-68.30% | Reduce |
| AMERIPRISE FINANCIAL INC |
| <0.01% | 0.01% | #81 | $18.5M | 150,560 | $32.5M | 514,035 | -363,475-70.71% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #114 | $18.3M | 149,054 | $286,512 | 4,537 | +144,517+3,185.30% | Add |
| Sofinnova Investments, Inc. |
| 0.95% | 0.18% | #13 | $18.3M | 148,993 | $4.6M | 73,315 | +75,678+103.22% | Add |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.01% | — | #73 | $18.2M | 147,841 | $0 | 0 | +147,841 | New Buy |
| Kalehua Capital Management LLC |
| 12.84% | 6.51% | #2 | $17.9M | 145,695 | $9.2M | 145,695 | 00.00% | Unchanged |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #79 | $17.4M | 141,223 | $6.2M | 97,985 | +43,238+44.13% | Add |
| Ensign Peak Advisors, Inc |
| 0.03% | 0.02% | #48 | $15.7M | 127,868 | $9.5M | 150,000 | -22,132-14.75% | Reduce |
| SEVEN GRAND MANAGERS, LLC |
| 0.62% | 0.32% | #17 | $15.4M | 125,000 | $4.7M | 74,750 | +50,250+67.22% | Add |
| MASTERS CAPITAL MANAGEMENT LLC |
| 0.32% | 0.21% | #21 | $12.3M | 100,000 | $6.3M | 100,000 | 00.00% | Unchanged |
| MYDA Advisors LLC |
| 1.83% | 1.25% | #7 | $12.3M | 100,000 | $7.6M | 120,000 | -20,000-16.67% | Reduce |
| Affinity Asset Advisors, LLC |
| 0.56% | 0.23% | #19 | $12.3M | 100,000 | $4.4M | 70,000 | +30,000+42.86% | Add |
| FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #91 | $11.8M | 96,058 | $12.6M | 200,000 | -103,942-51.97% | Reduce |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 1.21% | — | #10 | $11.7M | 95,000 | $0 | 0 | +95,000 | New Buy |
| GILDER GAGNON HOWE & CO LLC |
| 0.12% | — | #34 | $11.7M | 94,864 | $0 | 0 | +94,864 | New Buy |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | — | #58 | $10.1M | 81,852 | $0 | 0 | +81,852 | New Buy |
| Seven Fleet Capital Management LP |
| 1.62% | — | #8 | $9.8M | 80,000 | $0 | 0 | +80,000 | New Buy |
| MORGAN STANLEY |
| <0.01% | — | #126 | $9.3M | 75,876 | $0 | 0 | +75,876 | New Buy |
| DV EQUITIES, LLC |
| 1.23% | — | #9 | $8.6M | 70,000 | $0 | 0 | +70,000 | New Buy |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | 0.01% | #102 | $8.4M | 68,531 | $30.2M | 477,833 | -409,302-85.66% | Reduce |
