| FMR LLC |
| 0.02% | 0.01% | #75 | $508.8M | 10.0M | $267.7M | 6.8M | +3.2M+46.80% | Add |
| ORBIMED ADVISORS LLC |
| 6.49% | 6.18% | #2 | $343.9M | 6.8M | $312.0M | 8.0M | -1.2M-14.86% | Reduce |
| Polar Capital Holdings Plc |
| 0.77% | 0.71% | #28 | $326.4M | 6.4M | $198.6M | 5.1M | +1.4M+26.94% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #122 | $221.3M | 4.4M | $144.4M | 3.7M | +674,997+18.32% | Add |
| Vestal Point Capital, LP |
| 4.74% | 3.56% | #6 | $203.0M | 4.0M | $127.4M | 3.3M | +750,000+23.08% | Add |
| Commodore Capital LP |
| 9.9% | 7.43% | #1 | $166.2M | 3.3M | $128.4M | 3.3M | 00.00% | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | <0.01% | #82 | $147.4M | 2.9M | $3.8M | 97,747 | +2.8M+2,870.84% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #127 | $130.4M | 2.6M | $0 | 0 | +2.6M | New Buy |
| CITADEL ADVISORS LLC |
| 0.01% | 0.01% | #86 | $108.7M | 2.1M | $73.4M | 1.9M | +269,477+14.40% | Add |
| Fairmount Funds Management LLC |
| 6.22% | 5.25% | #3 | $94.2M | 1.9M | $72.7M | 1.9M | 00.00% | Unchanged |
| Siren, L.L.C. |
| 1.82% | 0.81% | #16 | $90.1M | 1.8M | $29.3M | 746,226 | +1.0M+137.78% | Add |
| Bellevue Group AG |
| 1.59% | 2.17% | #19 | $75.6M | 1.5M | $91.0M | 2.3M | -830,867-35.80% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #118 | $71.4M | 1.4M | $41.8M | 1.1M | +340,782+31.96% | Add |
| First Light Asset Management, LLC |
| 4.2% | 0.71% | #8 | $69.1M | 1.4M | $7.9M | 201,867 | +1.2M+574.08% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #140 | $61.6M | 1.2M | $42.8M | 1.1M | +122,510+11.23% | Add |
| Pictet Asset Management Holding SA |
| 0.06% | 0.04% | #63 | $59.0M | 1.2M | $36.4M | 929,544 | +232,240+24.98% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.08% | — | #60 | $55.0M | 1.1M | $0 | 0 | +1.1M | New Buy |
| Novo Holdings A/S |
| 2.96% | 4.07% | #12 | $50.8M | 1.0M | $50.2M | 1.3M | -280,000-21.88% | Reduce |
| First Turn Management, LLC |
| 5.18% | 2.73% | #5 | $48.4M | 954,360 | $24.5M | 623,839 | +330,521+52.98% | Add |
| SAMLYN CAPITAL, LLC |
| 0.75% | — | #29 | $46.3M | 912,637 | $0 | 0 | +912,637 | New Buy |
| BAKER BROS. ADVISORS LP |
| 0.23% | 0.2% | #45 | $45.9M | 905,191 | $35.5M | 905,191 | 00.00% | Unchanged |
| Candriam S.C.A. |
| 0.21% | 0.03% | #47 | $45.9M | 905,674 | $7.0M | 453,019 | +452,655+99.92% | Add |
| Tri Locum Partners LP |
| 5.41% | — | #4 | $44.0M | 866,716 | $0 | 0 | +866,716 | New Buy |
| ALLIANCEBERNSTEIN L.P. |
| 0.01% | <0.01% | #87 | $35.1M | 896,161 | $11.9M | 771,885 | +124,276+16.10% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #107 | $34.1M | 671,412 | $26.7M | 681,715 | -10,303-1.51% | Reduce |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.04% | 0.02% | #70 | $30.8M | 607,189 | $12.2M | 310,025 | +297,164+95.85% | Add |
| Jupiter Topco LLC |
| 0.01% | — | #85 | $30.6M | 604,122 | $0 | 0 | +604,122 | New Buy |
| AMERICAN CENTURY COMPANIES INC |
| 0.01% | <0.01% | #84 | $28.7M | 566,165 | $2.4M | 62,116 | +504,049+811.46% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #146 | $28.6M | 562,763 | $0 | 0 | +562,763 | New Buy |
| Avidity Partners Management LP |
| 4.47% | 3.18% | #7 | $27.9M | 550,000 | $15.7M | 400,000 | +150,000+37.50% | Add |
| MARSHALL WACE, LLP |
| 0.02% | — | #76 | $27.0M | 532,269 | $0 | 0 | +532,269 | New Buy |
| Venrock Adviser, LLC |
| 0.81% | 2.53% | #27 | $26.7M | 526,331 | $67.7M | 1.7M | -1.2M-69.51% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #144 | $25.9M | 509,928 | $5.3M | 258,384 | +251,544+97.35% | Add |
| Affinity Asset Advisors, LLC |
| 1.15% | 1.19% | #22 | $25.4M | 500,000 | $23.0M | 586,904 | -86,904-14.81% | Reduce |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 2.58% | — | #13 | $24.8M | 489,382 | $0 | 0 | +489,382 | New Buy |
| Logos Global Management LP |
| 1.02% | 2.04% | #24 | $23.6M | 465,000 | $40.8M | 1.0M | -575,000-55.29% | Reduce |
| Rock Springs Capital Management LP |
| 1.15% | 1.91% | #21 | $23.6M | 464,625 | $32.4M | 826,500 | -361,875-43.78% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #130 | $22.4M | 440,938 | $14.6M | 372,316 | +68,622+18.43% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #125 | $21.5M | 424,440 | $14.1M | 360,577 | +63,863+17.71% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #103 | $20.9M | 411,362 | $13.5M | 345,318 | +66,044+19.13% | Add |
| Nicholas Investment Partners, LP |
| 1.12% | 0.52% | #23 | $19.9M | 391,529 | $7.2M | 182,728 | +208,801+114.27% | Add |
| ADAR1 Capital Management, LLC |
| 0.91% | 0.76% | #25 | $19.7M | 387,718 | $12.9M | 329,540 | +58,178+17.65% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #117 | $19.5M | 383,490 | $0 | 0 | +383,490 | New Buy |
| Nuveen, LLC |
| <0.01% | <0.01% | #114 | $19.0M | 374,217 | $4.2M | 105,883 | +268,334+253.43% | Add |
| Seven Fleet Capital Management LP |
| 3.06% | 2.04% | #11 | $18.5M | 365,386 | $6.4M | 164,030 | +201,356+122.76% | Add |
| Woodline Partners LP |
| 0.05% | 0.04% | #65 | $17.6M | 347,142 | $11.8M | 301,673 | +45,469+15.07% | Add |
| STEMPOINT CAPITAL LP |
| 2.51% | 2.63% | #15 | $17.6M | 346,914 | $14.2M | 363,438 | -16,524-4.55% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #135 | $17.4M | 342,115 | $11.1M | 283,544 | +58,571+20.66% | Add |
| LORD, ABBETT & CO. LLC |
| 0.05% | — | #67 | $16.8M | 330,759 | $0 | 0 | +330,759 | New Buy |
| Spruce Street Capital LP |
| 3.28% | 3.1% | #9 | $16.7M | 329,006 | $12.9M | 329,006 | 00.00% | Unchanged |
