| EcoR1 Capital, LLC |
| 29.2% | 24.41% | #1 | $600.4M | 23.0M | $575.2M | 23.0M | 00.00% | Unchanged |
| Rubric Capital Management LP |
| 1.68% | 1.86% | #4 | $183.0M | 7.0M | $175.3M | 7.0M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #80 | $111.1M | 4.3M | $114.0M | 4.6M | -302,858-6.65% | Reduce |
| PERCEPTIVE ADVISORS LLC |
| 1.64% | 1.72% | #6 | $109.3M | 4.2M | $87.9M | 3.5M | +672,875+19.17% | Add |
| BVF INC/IL |
| 2.44% | 2.98% | #3 | $95.4M | 3.6M | $93.5M | 3.7M | -85,000-2.28% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #65 | $58.3M | 2.2M | $68.1M | 4.0M | -1.8M-44.00% | Reduce |
| BNP Paribas Asset Management Holding S.A. |
| 0.05% | — | #32 | $46.6M | 1.8M | $0 | 0 | +1.8M | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #105 | $40.8M | 1.6M | $42.7M | 1.7M | -146,582-8.59% | Reduce |
| Assenagon Asset Management S.A. |
| 0.04% | 0.03% | #36 | $32.7M | 1.3M | $18.2M | 727,986 | +524,041+71.99% | Add |
| Nextech Invest Ltd. |
| 1.39% | 1.96% | #7 | $29.1M | 1.1M | $27.9M | 1.1M | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #107 | $28.4M | 1.1M | $25.3M | 1.0M | +76,439+7.55% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | 0.01% | #59 | $26.0M | 994,955 | $28.5M | 1.1M | -144,180-12.66% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | 0.01% | #69 | $25.3M | 966,336 | $31.3M | 1.3M | -284,182-22.73% | Reduce |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.03% | — | #38 | $23.3M | 889,802 | $0 | 0 | +889,802 | New Buy |
| FMR LLC |
| <0.01% | <0.01% | #108 | $18.4M | 702,568 | $16.7M | 667,153 | +35,415+5.31% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #101 | $18.1M | 692,410 | $16.5M | 659,940 | +32,470+4.92% | Add |
| Prosight Management, LP |
| 3.04% | 2.21% | #2 | $17.6M | 674,434 | $13.5M | 539,049 | +135,385+25.12% | Add |
| Qube Research & Technologies Ltd |
| 0.01% | 0.01% | #44 | $15.5M | 593,590 | $12.8M | 511,937 | +81,653+15.95% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #119 | $13.3M | 510,032 | $12.5M | 499,875 | +10,157+2.03% | Add |
| Redmile Group, LLC |
| 0.86% | 0.82% | #10 | $12.9M | 491,654 | $12.3M | 491,654 | 00.00% | Unchanged |
| Capricorn Fund Managers Ltd |
| 1.01% | 3.93% | #8 | $12.7M | 486,529 | $25.2M | 1.0M | -520,681-51.70% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #93 | $12.3M | 470,822 | $15.0M | 599,486 | -128,664-21.46% | Reduce |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| <0.01% | 0.01% | #56 | $10.9M | 418,497 | $18.6M | 743,898 | -325,401-43.74% | Reduce |
| DEUTSCHE BANK AG\ |
| <0.01% | 0.01% | #67 | $10.4M | 397,190 | $23.1M | 921,250 | -524,060-56.89% | Reduce |
| Hillsdale Investment Management Inc. |
| 0.23% | 0.24% | #16 | $10.0M | 382,922 | $8.7M | 345,622 | +37,300+10.79% | Add |
| FIRST TRUST ADVISORS LP |
| 0.01% | — | #55 | $8.9M | 340,363 | $0 | 0 | +340,363 | New Buy |
| Granahan Investment Management, LLC |
| 0.31% | 0.3% | #13 | $8.8M | 336,157 | $6.3M | 250,773 | +85,384+34.05% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #99 | $8.4M | 321,073 | $8.0M | 320,210 | +863+0.27% | Add |
| Pictet Asset Management Holding SA |
| 0.01% | <0.01% | #52 | $7.4M | 308,187 | $231,770 | 9,256 | +298,931+3,229.59% | Add |
| PICTON MAHONEY ASSET MANAGEMENT |
| 0.05% | 0.05% | #29 | $7.1M | 271,343 | $6.4M | 256,690 | +14,653+5.71% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #135 | $5.9M | 224,200 | $6.9M | 274,921 | -50,721-18.45% | Reduce |
| SILVERCREST ASSET MANAGEMENT GROUP LLC |
| 0.04% | 0.03% | #37 | $5.8M | 223,766 | $4.1M | 163,649 | +60,117+36.74% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #144 | $5.7M | 219,071 | $5.9M | 236,754 | -17,683-7.47% | Reduce |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #102 | $5.7M | 217,199 | $4.7M | 189,636 | +27,563+14.53% | Add |
| SummitTX Capital, L.P. |
| 0.14% | 0.25% | #21 | $5.5M | 210,802 | $8.0M | 321,427 | -110,625-34.42% | Reduce |
| Man Group plc |
| 0.01% | 0.01% | #48 | $5.5M | 210,779 | $4.8M | 189,890 | +20,889+11.00% | Add |
| FEDERATED HERMES, INC. |
| 0.01% | 0.01% | #53 | $4.9M | 187,995 | $4.6M | 182,410 | +5,585+3.06% | Add |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #89 | $4.4M | 166,416 | $4.4M | 176,411 | -9,995-5.67% | Reduce |
| STATE OF WISCONSIN INVESTMENT BOARD |
| 0.01% | <0.01% | #49 | $4.1M | 155,579 | $1.7M | 66,106 | +89,473+135.35% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #127 | $4.0M | 152,416 | $4.6M | 185,124 | -32,708-17.67% | Reduce |
| KENNEDY CAPITAL MANAGEMENT LLC |
| 0.07% | 0.08% | #27 | $3.8M | 145,386 | $3.7M | 148,226 | -2,840-1.92% | Reduce |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #76 | $3.8M | 144,807 | $5.9M | 235,621 | -90,814-38.54% | Reduce |
| DIADEMA PARTNERS LP |
| 0.46% | 0.61% | #12 | $3.7M | 142,132 | $3.6M | 142,132 | 00.00% | Unchanged |
| CITIGROUP INC |
| <0.01% | <0.01% | #90 | $3.4M | 131,441 | $2.9M | 114,327 | +17,114+14.97% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #124 | $3.4M | 131,106 | $3.1M | 124,105 | +7,001+5.64% | Add |
| XTX Topco Ltd |
| 0.04% | 0.06% | #35 | $3.3M | 125,877 | $3.6M | 143,882 | -18,005-12.51% | Reduce |
| Nuveen, LLC |
| <0.01% | <0.01% | #109 | $3.1M | 119,389 | $16.3M | 651,662 | -532,273-81.68% | Reduce |
| PANAGORA ASSET MANAGEMENT INC |
| 0.01% | 0.02% | #45 | $3.1M | 118,603 | $5.2M | 206,854 | -88,251-42.66% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #143 | $3.0M | 115,095 | $4.3M | 171,779 | -56,684-33.00% | Reduce |
| Invesco Ltd. |
| <0.01% | <0.01% | #154 | $2.9M | 112,212 | $3.1M | 125,630 | -13,418-10.68% | Reduce |
