| GILEAD SCIENCES, INC. |
| 58.76% | 32.05% | #1 | $968.8M | 31.4M | $678.8M | 31.4M | 00.00% | Unchanged |
| BlackRock, Inc. |
| 0.01% | 0.01% | #68 | $506.1M | 16.4M | $328.9M | 15.2M | +1.2M+7.81% | Add |
| STATE STREET CORP |
| 0.01% | <0.01% | #83 | $185.9M | 6.0M | $116.9M | 5.4M | +616,583+11.39% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.03% | 0.02% | #43 | $181.8M | 5.9M | $131.5M | 6.1M | -194,068-3.19% | Reduce |
| MONTANOVA CAPITAL, LLC |
| 2.69% | 2.78% | #3 | $147.3M | 4.8M | $108.7M | 5.0M | -254,570-5.06% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | <0.01% | #78 | $138.0M | 4.5M | $92.3M | 4.3M | +203,472+4.76% | Add |
| FMR LLC |
| 0.01% | <0.01% | #84 | $124.9M | 4.0M | $25.2M | 1.2M | +2.9M+247.54% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #115 | $119.9M | 3.9M | $83.3M | 3.9M | +31,621+0.82% | Add |
| CITADEL ADVISORS LLC |
| 0.01% | <0.01% | #61 | $97.5M | 3.2M | $30.7M | 1.4M | +1.7M+122.63% | Add |
| Woodline Partners LP |
| 0.29% | 0.31% | #22 | $92.7M | 3.0M | $81.6M | 3.8M | -770,000-20.38% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #97 | $75.5M | 2.4M | $48.7M | 2.3M | +196,382+8.72% | Add |
| Siren, L.L.C. |
| 1.51% | 1.8% | #9 | $74.6M | 2.4M | $65.0M | 3.0M | -586,647-19.51% | Reduce |
| Fisher Asset Management, LLC |
| 0.02% | 0.02% | #49 | $66.0M | 2.1M | $47.3M | 2.2M | -51,008-2.33% | Reduce |
| MARSHALL WACE, LLP |
| 0.05% | 0.08% | #38 | $60.0M | 1.9M | $81.2M | 3.8M | -1.8M-48.29% | Reduce |
| SAMLYN CAPITAL, LLC |
| 0.78% | 0.7% | #16 | $47.7M | 1.5M | $41.2M | 1.9M | -361,230-18.93% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #65 | $44.2M | 1.4M | $30.8M | 1.4M | +8,097+0.57% | Add |
| BNP Paribas Asset Management Holding S.A. |
| 0.04% | — | #39 | $43.8M | 1.4M | $0 | 0 | +1.4M | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #101 | $42.8M | 1.4M | $21.6M | 999,786 | +387,780+38.79% | Add |
| Soleus Capital Management, L.P. |
| 1.24% | 0.4% | #13 | $36.0M | 1.2M | $9.8M | 451,983 | +716,755+158.58% | Add |
| Sofinnova Investments, Inc. |
| 1.51% | 0.76% | #10 | $29.2M | 945,690 | $19.9M | 923,086 | +22,604+2.45% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #98 | $29.0M | 941,756 | $19.5M | 903,638 | +38,118+4.22% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #106 | $28.7M | 932,523 | $18.2M | 840,305 | +92,218+10.97% | Add |
| Parkman Healthcare Partners LLC |
| 2.9% | 2.69% | #2 | $28.3M | 919,266 | $26.1M | 1.2M | -288,008-23.86% | Reduce |
| Invesco Ltd. |
| <0.01% | <0.01% | #121 | $26.1M | 845,233 | $17.7M | 820,820 | +24,413+2.97% | Add |
| BAKER BROS. ADVISORS LP |
| 0.13% | 0.05% | #25 | $26.0M | 844,816 | $9.0M | 415,621 | +429,195+103.27% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #129 | $25.8M | 835,504 | $14.0M | 646,068 | +189,436+29.32% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #138 | $24.5M | 795,912 | $20.9M | 1.5M | -740,176-48.19% | Reduce |
| Candriam S.C.A. |
| 0.09% | 0.09% | #29 | $20.4M | 661,981 | $18.8M | 790,613 | -128,632-16.27% | Reduce |
| Aberdeen Group plc |
| 0.03% | 0.03% | #44 | $20.1M | 650,712 | $16.6M | 769,787 | -119,075-15.47% | Reduce |
| Logos Global Management LP |
| 0.86% | 1.29% | #15 | $20.0M | 650,000 | $25.9M | 1.2M | -550,000-45.83% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.01% | #55 | $19.6M | 635,404 | $6.8M | 312,690 | +322,714+103.21% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #96 | $19.0M | 616,088 | $12.6M | 582,920 | +33,168+5.69% | Add |
| T. Rowe Price Investment Management, Inc. |
| 0.01% | — | #59 | $18.2M | 589,546 | $0 | 0 | +589,546 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #114 | $16.7M | 543,009 | $11.0M | 511,166 | +31,843+6.23% | Add |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.06% | 0.04% | #33 | $15.8M | 512,084 | $9.3M | 430,346 | +81,738+18.99% | Add |
| Ikarian Capital, LLC |
| 1.65% | — | #8 | $15.6M | 504,559 | $0 | 0 | +504,559 | New Buy |
| Decheng Capital LLC |
| 1.96% | 1.56% | #6 | $14.3M | 464,779 | $10.3M | 477,819 | -13,040-2.73% | Reduce |
| DAFNA Capital Management LLC |
| 2.6% | 2.18% | #4 | $13.6M | 441,829 | $9.6M | 443,829 | -2,000-0.45% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #157 | $13.1M | 418,243 | $1.7M | 80,817 | +337,426+417.52% | Add |
| PRINCIPAL FINANCIAL GROUP INC |
| 0.01% | <0.01% | #76 | $13.1M | 423,366 | $8.9M | 413,778 | +9,588+2.32% | Add |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.02% | 0.01% | #51 | $11.7M | 379,100 | $8.2M | 379,100 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #133 | $11.4M | 369,056 | $6.2M | 288,857 | +80,199+27.76% | Add |
| Patient Square Capital LP |
| 1.7% | 0.75% | #7 | $11.0M | 355,800 | $4.2M | 195,000 | +160,800+82.46% | Add |
| DIADEMA PARTNERS LP |
| 1.32% | 0.88% | #12 | $10.7M | 347,810 | $5.1M | 238,142 | +109,668+46.05% | Add |
| PDT Partners, LLC |
| 0.52% | 0.5% | #18 | $10.0M | 323,567 | $8.4M | 388,338 | -64,771-16.68% | Reduce |
| PUBLIC SECTOR PENSION INVESTMENT BOARD |
| 0.02% | 0.02% | #47 | $9.2M | 298,156 | $6.6M | 303,316 | -5,160-1.70% | Reduce |
| FIRST TRUST ADVISORS LP |
| <0.01% | <0.01% | #90 | $8.4M | 271,434 | $282,916 | 13,098 | +258,336+1,972.33% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #126 | $7.2M | 234,052 | $4.8M | 221,710 | +12,342+5.57% | Add |
| Connor, Clark & Lunn Investment Management Ltd. |
| 0.01% | 0.01% | #58 | $6.9M | 225,008 | $6.1M | 281,681 | -56,673-20.12% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #165 | $6.9M | 224,388 | $4.7M | 216,471 | +7,917+3.66% | Add |
