| BlackRock, Inc. |
| <0.01% | <0.01% | #133 | $196.6M | 13.2M | $94.9M | 11.2M | +2.0M+17.72% | Add |
| MONTANOVA CAPITAL, LLC |
| 2.8% | 2.22% | #7 | $153.1M | 10.3M | $87.0M | 10.3M | 00.00% | Unchanged |
| STIFEL FINANCIAL CORP |
| 0.12% | 0.08% | #42 | $147.9M | 9.9M | $84.1M | 9.9M | +280+0.00% | Add |
| Jupiter Topco LLC |
| 0.05% | — | #54 | $127.9M | 8.6M | $0 | 0 | +8.6M | New Buy |
| Woodline Partners LP |
| 0.35% | 0.01% | #21 | $114.0M | 7.7M | $2.5M | 300,389 | +7.4M+2,450.12% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #130 | $103.4M | 6.9M | $56.0M | 6.6M | +328,231+4.96% | Add |
| INFINITUM ASSET MANAGEMENT, LLC |
| 9.46% | 6.6% | #2 | $93.0M | 6.3M | $52.9M | 6.3M | 00.00% | Unchanged |
| D. E. Shaw & Co., Inc. |
| 0.03% | 0.01% | #67 | $62.4M | 4.2M | $24.1M | 2.8M | +1.3M+47.17% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| 0.02% | 0.01% | #74 | $61.8M | 4.2M | $16.7M | 2.0M | +2.2M+110.10% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #141 | $49.5M | 3.3M | $23.4M | 2.8M | +555,427+20.07% | Add |
| FMR LLC |
| <0.01% | <0.01% | #165 | $44.1M | 3.0M | $20.0M | 2.4M | +605,583+25.67% | Add |
| Royalty Pharma Sub-Manager, LLC |
| 18.06% | 14.38% | #1 | $43.7M | 2.9M | $24.8M | 2.9M | 00.00% | Unchanged |
| Cormorant Asset Management, LP |
| 1.97% | 0.75% | #10 | $38.8M | 2.6M | $14.9M | 1.8M | +850,000+48.30% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #125 | $38.4M | 2.6M | $21.3M | 2.5M | +69,865+2.78% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #112 | $37.5M | 2.5M | $12.1M | 1.4M | +1.1M+76.58% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #173 | $37.0M | 2.5M | $19.3M | 2.3M | +209,666+9.20% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #123 | $30.4M | 2.0M | $16.5M | 2.0M | +88,969+4.55% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.03% | 0.03% | #62 | $28.0M | 1.9M | $20.7M | 2.4M | -565,682-23.13% | Reduce |
| TCG Crossover Management, LLC |
| 0.64% | 1.12% | #15 | $26.5M | 1.8M | $39.2M | 4.6M | -2.9M-61.57% | Reduce |
| Nuveen, LLC |
| 0.01% | <0.01% | #99 | $26.0M | 1.7M | $6.3M | 745,748 | +998,586+133.90% | Add |
| Rubric Capital Management LP |
| 0.23% | — | #27 | $25.6M | 1.7M | $0 | 0 | +1.7M | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #209 | $22.2M | 1.5M | $10.7M | 1.3M | +218,920+17.24% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #177 | $22.0M | 1.5M | $6.4M | 759,425 | +718,413+94.60% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #151 | $21.7M | 1.5M | $18.8M | 2.2M | -760,324-34.29% | Reduce |
| ARS Investment Partners, LLC |
| 0.89% | 0.61% | #13 | $20.4M | 1.4M | $11.7M | 1.4M | -4,643-0.34% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.01% | 0.01% | #89 | $18.2M | 1.2M | $13.1M | 1.5M | -319,916-20.72% | Reduce |
| Capital Research Global Investors |
| <0.01% | <0.01% | #145 | $17.8M | 1.2M | $11.3M | 1.3M | -133,247-10.00% | Reduce |
| MYDA Advisors LLC |
| 2.64% | 1.7% | #8 | $17.7M | 1.2M | $10.4M | 1.2M | -35,000-2.86% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #179 | $17.7M | 1.2M | $13.1M | 1.5M | -361,085-23.32% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #157 | $17.7M | 1.2M | $8.5M | 1.0M | +184,801+18.45% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #148 | $16.5M | 1.1M | $8.0M | 941,077 | +168,206+17.87% | Add |
| STEMPOINT CAPITAL LP |
| 2.33% | 2.49% | #9 | $16.4M | 1.6M | $13.5M | 1.6M | -30,291-1.90% | Reduce |
| Simplify Asset Management Inc. |
| 0.22% | 0.12% | #28 | $15.5M | 1.0M | $7.6M | 898,400 | +141,855+15.79% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | 0.02% | #77 | $14.9M | 1.0M | $12.7M | 1.5M | -497,793-33.24% | Reduce |
| Qube Research & Technologies Ltd |
| 0.01% | 0.01% | #82 | $13.5M | 905,935 | $13.0M | 1.5M | -634,510-41.19% | Reduce |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
| 0.06% | 0.04% | #52 | $13.1M | 882,724 | $10.3M | 1.2M | -337,106-27.64% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #202 | $12.5M | 841,351 | $8.2M | 545,815 | +295,536+54.15% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #140 | $12.3M | 828,779 | $5.9M | 701,591 | +127,188+18.13% | Add |
| Ikarian Capital, LLC |
| 1.18% | 0.28% | #12 | $11.1M | 748,181 | $3.5M | 412,481 | +335,700+81.39% | Add |
| Erste Asset Management GmbH |
| 0.09% | 0.05% | #46 | $11.0M | 737,300 | $5.6M | 693,300 | +44,000+6.35% | Add |
| 5AM Venture Management, LLC |
| 3.82% | 1.74% | #5 | $11.0M | 738,972 | $6.3M | 738,972 | 00.00% | Unchanged |
| Integral Health Asset Management, LLC |
| 0.41% | 0.4% | #18 | $10.4M | 700,000 | $8.5M | 1.0M | -300,000-30.00% | Reduce |
| MARSHALL WACE, LLP |
| 0.01% | <0.01% | #93 | $9.7M | 651,349 | $3.0M | 352,605 | +298,744+84.72% | Add |
| Caption Management, LLC |
| 0.04% | 0.02% | #59 | $9.2M | 620,000 | $3.5M | 410,339 | +209,661+51.09% | Add |
| Longaeva Partners L.P. |
| 0.2% | — | #32 | $8.9M | 599,903 | $0 | 0 | +599,903 | New Buy |
| Sarissa Capital Management LP |
| 4.87% | 3.02% | #3 | $8.7M | 582,312 | $4.8M | 563,184 | +19,128+3.40% | Add |
| PFIZER INC |
| 4.7% | 1.77% | #4 | $8.0M | 505,645 | $4.2M | 505,645 | 00.00% | Unchanged |
| Eversept Partners, LP |
| 0.4% | — | #19 | $7.7M | 515,804 | $0 | 0 | +515,804 | New Buy |
| Trexquant Investment LP |
| 0.04% | 0.05% | #57 | $7.5M | 503,694 | $7.4M | 877,774 | -374,080-42.62% | Reduce |
| ADAR1 Capital Management, LLC |
| 0.34% | 0.02% | #22 | $7.5M | 501,687 | $378,813 | 44,777 | +456,910+1,020.41% | Add |
