| FMR LLC |
| 0.01% | 0.01% | #60 | $300.4M | 16.7M | $231.2M | 16.6M | +97,368+0.59% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #96 | $158.5M | 8.8M | $122.7M | 8.8M | -1,751-0.02% | Reduce |
| PERCEPTIVE ADVISORS LLC |
| 2.25% | 2.25% | #9 | $149.7M | 8.3M | $115.2M | 8.3M | +50,000+0.60% | Add |
| TCG Crossover Management, LLC |
| 2.7% | 2.48% | #6 | $112.1M | 6.2M | $86.8M | 6.2M | 00.00% | Unchanged |
| Commodore Capital LP |
| 6.04% | 4.54% | #2 | $101.5M | 5.7M | $78.5M | 5.7M | 00.00% | Unchanged |
| Jupiter Topco LLC |
| 0.04% | — | #49 | $94.0M | 5.2M | $0 | 0 | +5.2M | New Buy |
| Saturn V Capital Management LP |
| 11.91% | 10.95% | #1 | $83.0M | 4.6M | $60.5M | 4.3M | +274,216+6.30% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #108 | $75.9M | 4.2M | $57.6M | 4.1M | +82,649+2.00% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #88 | $56.2M | 3.1M | $26.5M | 2.0M | +1.2M+60.53% | Add |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.32% | 0.31% | #23 | $54.5M | 3.0M | $41.5M | 3.0M | +49,823+1.67% | Add |
| First Light Asset Management, LLC |
| 3.3% | 3.97% | #5 | $54.3M | 3.0M | $44.3M | 3.2M | -167,389-5.25% | Reduce |
| FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #64 | $53.0M | 3.0M | $31.4M | 2.3M | +688,656+30.45% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #77 | $51.3M | 2.9M | $36.5M | 2.6M | +232,248+8.84% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #113 | $46.8M | 2.6M | $32.8M | 2.4M | +240,176+10.16% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #97 | $41.9M | 2.3M | $30.7M | 2.2M | +124,383+5.63% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #102 | $34.9M | 1.9M | $2.0M | 159,663 | +1.7M+1,067.24% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.05% | 0.08% | #43 | $34.1M | 1.9M | $49.5M | 3.6M | -1.7M-46.64% | Reduce |
| Siren, L.L.C. |
| 0.54% | 0.47% | #17 | $26.6M | 1.5M | $17.1M | 1.2M | +250,586+20.37% | Add |
| 683 Capital Management, LLC |
| 1.21% | 1.18% | #12 | $24.7M | 1.4M | $22.6M | 1.6M | -250,488-15.40% | Reduce |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 0.32% | 0.35% | #22 | $23.8M | 1.3M | $21.0M | 1.5M | -186,422-12.31% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #125 | $19.1M | 1.1M | $13.1M | 944,781 | +116,753+12.36% | Add |
| Alyeska Investment Group, L.P. |
| 0.05% | — | #42 | $18.9M | 1.1M | $0 | 0 | +1.1M | New Buy |
| Almitas Capital LLC |
| 4.08% | 6.67% | #3 | $17.5M | 974,881 | $29.5M | 2.1M | -1.1M-54.07% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #89 | $16.2M | 902,463 | $12.5M | 903,192 | -729-0.08% | Reduce |
| Jones Hill Capital LP |
| 3.41% | 4.76% | #4 | $16.1M | 894,058 | $22.2M | 1.6M | -704,736-44.08% | Reduce |
| Woodline Partners LP |
| 0.05% | 0.04% | #44 | $15.2M | 846,387 | $11.8M | 845,800 | +587+0.07% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #106 | $14.9M | 831,740 | $10.8M | 779,908 | +51,832+6.65% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #121 | $14.8M | 821,841 | $18.5M | 1.3M | -508,848-38.24% | Reduce |
| Boxer Capital Management, LLC |
| 1.08% | 1.46% | #13 | $14.4M | 800,000 | $11.1M | 800,000 | 00.00% | Unchanged |
| Aberdeen Group plc |
| 0.02% | — | #57 | $13.2M | 737,670 | $0 | 0 | +737,670 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #107 | $13.0M | 725,030 | $10.0M | 716,225 | +8,805+1.23% | Add |
| Connor, Clark & Lunn Investment Management Ltd. |
| 0.02% | 0.03% | #53 | $12.9M | 721,002 | $12.1M | 868,325 | -147,323-16.97% | Reduce |
| GREAT POINT PARTNERS LLC |
| 2.38% | 5.59% | #8 | $12.6M | 700,000 | $24.3M | 1.8M | -1.1M-60.00% | Reduce |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.02% | #59 | $12.3M | 684,974 | $15.4M | 1.1M | -422,297-38.14% | Reduce |
| Qube Research & Technologies Ltd |
| 0.01% | 0.01% | #63 | $12.2M | 681,389 | $9.8M | 702,236 | -20,847-2.97% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #94 | $11.2M | 623,078 | $8.1M | 586,152 | +36,926+6.30% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | <0.01% | #72 | $10.7M | 593,435 | $2.3M | 161,945 | +431,490+266.44% | Add |
| DEUTSCHE BANK AG\ |
| <0.01% | 0.01% | #91 | $10.0M | 557,937 | $17.6M | 1.3M | -709,848-55.99% | Reduce |
| ADAR1 Capital Management, LLC |
| 0.44% | 0.82% | #19 | $9.6M | 534,478 | $13.9M | 1.0M | -466,126-46.58% | Reduce |
| Rock Springs Capital Management LP |
| 0.44% | 0.41% | #20 | $9.0M | 499,764 | $6.9M | 499,764 | 00.00% | Unchanged |
| Nantahala Capital Management, LLC |
| 0.29% | 0.27% | #24 | $8.7M | 486,684 | $7.4M | 535,684 | -49,000-9.15% | Reduce |
| FEDERATED HERMES, INC. |
| 0.01% | 0.01% | #62 | $8.3M | 462,205 | $5.1M | 363,546 | +98,659+27.14% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #135 | $8.0M | 447,839 | $4.9M | 354,002 | +93,837+26.51% | Add |
| Nearwater Capital Markets, Ltd |
| 0.13% | — | #33 | $7.6M | 425,000 | $0 | 0 | +425,000 | New Buy |
| Parkman Healthcare Partners LLC |
| 0.73% | 0.89% | #16 | $7.2M | 398,782 | $8.6M | 621,458 | -222,676-35.83% | Reduce |
| HighVista Strategies LLC |
| 1.58% | 1.35% | #11 | $6.9M | 386,080 | $4.9M | 352,085 | +33,995+9.66% | Add |
| STEMPOINT CAPITAL LP |
| 0.98% | 1.72% | #14 | $6.9M | 384,304 | $9.3M | 669,685 | -285,381-42.61% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #141 | $6.8M | 377,165 | $355,840 | 25,600 | +351,565+1,373.30% | Add |
| Logos Global Management LP |
| 0.27% | 0.49% | #25 | $6.3M | 350,000 | $9.7M | 700,000 | -350,000-50.00% | Reduce |
| Trexquant Investment LP |
| 0.04% | — | #51 | $6.3M | 349,439 | $0 | 0 | +349,439 | New Buy |
