| RA CAPITAL MANAGEMENT, L.P. |
| 1.36% | 2.07% | #6 | $156.7M | 27.0M | $195.6M | 27.0M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #106 | $111.6M | 19.2M | $102.4M | 14.1M | +5.1M+36.02% | Add |
| GSK plc |
| 17.6% | 22.08% | #2 | $106.0M | 18.2M | $132.3M | 18.2M | 00.00% | Unchanged |
| MAVERICK CAPITAL LTD |
| 0.53% | 0.95% | #7 | $59.7M | 10.3M | $82.1M | 11.3M | -1.0M-9.18% | Reduce |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.18% | 0.29% | #14 | $31.6M | 5.4M | $39.4M | 5.4M | +12,122+0.22% | Add |
| PRIMECAP MANAGEMENT CO/CA/ |
| 0.02% | 0.03% | #54 | $31.1M | 5.4M | $35.0M | 4.8M | +521,670+10.79% | Add |
| 683 Capital Management, LLC |
| 1.41% | 1.85% | #4 | $28.8M | 5.0M | $35.5M | 4.9M | +50,000+1.02% | Add |
| FMR LLC |
| <0.01% | <0.01% | #113 | $28.6M | 4.9M | $37.6M | 5.2M | -270,284-5.21% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #129 | $28.1M | 4.8M | $26.6M | 3.7M | +1.2M+31.72% | Add |
| M28 Capital Management LP |
| 56.53% | 61.83% | #1 | $26.7M | 4.6M | $33.3M | 4.6M | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #116 | $22.5M | 3.9M | $26.0M | 3.6M | +290,899+8.13% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.02% | 0.01% | #58 | $21.5M | 3.7M | $13.6M | 1.9M | +1.8M+97.42% | Add |
| ALGERT GLOBAL LLC |
| 0.19% | 0.14% | #13 | $16.4M | 2.8M | $9.5M | 1.3M | +1.5M+114.17% | Add |
| Qube Research & Technologies Ltd |
| 0.01% | <0.01% | #59 | $16.1M | 2.8M | $1.1M | 155,924 | +2.6M+1,680.35% | Add |
| Squarepoint Ops LLC |
| 0.02% | 0.02% | #57 | $14.8M | 2.5M | $13.9M | 1.9M | +629,052+32.89% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #136 | $14.1M | 2.4M | $3.7M | 507,290 | +1.9M+377.58% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #142 | $12.3M | 2.1M | $8.5M | 1.2M | +934,544+79.45% | Add |
| PFIZER INC |
| 6.42% | 5% | #3 | $10.9M | 1.9M | $11.9M | 1.9M | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #86 | $10.5M | 1.8M | $7.0M | 972,241 | +839,041+86.30% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | 0.01% | #120 | $10.5M | 1.8M | $63.1M | 8.7M | -6.9M-79.25% | Reduce |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #78 | $10.3M | 1.8M | $524,211 | 72,305 | +1.7M+2,351.04% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #180 | $10.2M | 1.8M | $11.7M | 1.6M | +139,550+8.66% | Add |
| SCHRODER INVESTMENT MANAGEMENT GROUP |
| 0.01% | 0.01% | #74 | $9.9M | 1.7M | $9.5M | 1.4M | +305,584+21.21% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | — | #100 | $9.9M | 1.7M | $0 | 0 | +1.7M | New Buy |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #60 | $9.9M | 1.7M | $4.3M | 597,220 | +1.1M+185.41% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #87 | $9.6M | 1.6M | $3.3M | 451,185 | +1.2M+265.27% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #132 | $9.4M | 1.6M | $10.0M | 1.4M | +238,752+17.26% | Add |
| Point72 Asset Management, L.P. |
| 0.01% | <0.01% | #68 | $8.6M | 1.5M | $265,350 | 36,600 | +1.5M+3,965.00% | Add |
| FEDERATED HERMES, INC. |
| 0.01% | 0.06% | #65 | $8.5M | 1.5M | $38.6M | 5.3M | -3.9M-72.43% | Reduce |
| RTW INVESTMENTS, LP |
| 0.07% | 0.1% | #31 | $7.8M | 1.4M | $9.8M | 1.4M | 00.00% | Unchanged |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #128 | $7.3M | 1.3M | $8.6M | 1.2M | +64,270+5.40% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #123 | $7.1M | 1.2M | $8.5M | 1.2M | +45,166+3.83% | Add |
| EMERALD ADVISERS, LLC |
| 0.17% | 0.29% | #18 | $7.1M | 1.2M | $9.1M | 1.3M | -37,218-2.95% | Reduce |
| MARSHALL WACE, LLP |
| <0.01% | 0.01% | #80 | $5.8M | 999,533 | $13.0M | 1.8M | -790,349-44.16% | Reduce |
| Pictet Asset Management Holding SA |
| 0.01% | 0.01% | #77 | $5.3M | 917,409 | $8.2M | 1.1M | -231,718-20.16% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #118 | $5.2M | 887,677 | $6.4M | 878,833 | +8,844+1.01% | Add |
| Aberdeen Group plc |
| 0.01% | 0.01% | #73 | $5.1M | 876,458 | $4.0M | 550,000 | +326,458+59.36% | Add |
| EMERALD MUTUAL FUND ADVISERS TRUST |
| 0.17% | 0.29% | #17 | $4.9M | 847,999 | $5.9M | 814,529 | +33,470+4.11% | Add |
| BAKER BROS. ADVISORS LP |
| 0.02% | 0.03% | #47 | $4.8M | 822,638 | $6.0M | 822,638 | 00.00% | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #95 | $4.7M | 811,057 | $2.0M | 281,023 | +530,034+188.61% | Add |
| CAPITAL FUND MANAGEMENT S.A. |
| 0.02% | 0.01% | #52 | $4.3M | 734,746 | $1.3M | 183,331 | +551,415+300.78% | Add |
| Walleye Capital LLC |
| 0.01% | 0.02% | #62 | $3.7M | 642,153 | $3.9M | 533,512 | +108,641+20.36% | Add |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.48% | 0.63% | #8 | $3.7M | 638,272 | $4.0M | 548,272 | +90,000+16.42% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #151 | $3.6M | 618,754 | $20.4M | 2.8M | -2.2M-78.04% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #186 | $3.5M | 618,172 | $4.4M | 670,170 | -51,998-7.76% | Reduce |
| Y-Intercept (Hong Kong) Ltd |
| 0.07% | 0.02% | #28 | $3.5M | 610,094 | $1.1M | 157,013 | +453,081+288.56% | Add |
| Susquehanna Portfolio Strategies, LLC |
| 0.06% | 0.02% | #34 | $3.5M | 608,194 | $1.4M | 195,840 | +412,354+210.56% | Add |
| TANG CAPITAL MANAGEMENT LLC |
| 0.16% | 0.22% | #19 | $3.5M | 600,000 | $4.4M | 600,000 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #147 | $3.5M | 596,637 | $3.9M | 538,997 | +57,640+10.69% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #134 | $3.2M | 549,282 | $4.8M | 657,720 | -108,438-16.49% | Reduce |
