| T. Rowe Price Investment Management, Inc. |
| 0.27% | 0.25% | #19 | $417.0M | 19.7M | $357.9M | 16.4M | +3.3M+20.24% | Add |
| FMR LLC |
| 0.02% | 0.02% | #52 | $360.0M | 17.0M | $371.1M | 17.0M | +17,599+0.10% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #96 | $186.6M | 8.8M | $178.6M | 8.2M | +636,818+7.80% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #85 | $116.4M | 5.5M | $118.1M | 5.4M | +94,724+1.75% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.02% | 0.02% | #50 | $110.4M | 5.2M | $103.5M | 4.7M | +478,239+10.11% | Add |
| Redmile Group, LLC |
| 6.99% | 8.05% | #2 | $104.1M | 4.9M | $121.6M | 5.6M | -647,295-11.64% | Reduce |
| PRIMECAP MANAGEMENT CO/CA/ |
| 0.06% | 0.08% | #34 | $97.1M | 4.6M | $104.7M | 4.8M | -206,800-4.32% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #109 | $96.4M | 4.6M | $96.9M | 4.4M | +121,592+2.74% | Add |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.53% | 0.66% | #11 | $92.1M | 4.3M | $89.7M | 4.1M | +246,238+6.01% | Add |
| Enavate Sciences GP, LLC |
| 22.17% | 22.48% | #1 | $76.6M | 3.6M | $79.0M | 3.6M | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #90 | $58.4M | 2.8M | $56.0M | 2.6M | +194,225+7.58% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #98 | $51.0M | 2.4M | $21.5M | 1.8M | +574,124+31.31% | Add |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 4.44% | 4.13% | #4 | $42.7M | 2.0M | $40.5M | 1.9M | +166,731+9.01% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #105 | $39.0M | 1.8M | $53.6M | 2.8M | -929,288-33.45% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | 0.01% | #81 | $37.6M | 1.8M | $62.5M | 2.9M | -1.1M-37.97% | Reduce |
| Sofinnova Investments, Inc. |
| 1.88% | 1.41% | #5 | $36.5M | 1.7M | $37.2M | 1.7M | +18,412+1.08% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #95 | $32.0M | 1.5M | $24.1M | 1.1M | +411,013+37.31% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #125 | $28.6M | 1.3M | $22.0M | 1.0M | +342,004+33.96% | Add |
| PRINCIPAL FINANCIAL GROUP INC |
| 0.01% | 0.02% | #53 | $28.6M | 1.3M | $30.1M | 1.4M | -29,509-2.14% | Reduce |
| READYSTATE ASSET MANAGEMENT LP |
| 1.45% | 1.28% | #7 | $28.5M | 1.3M | $28.5M | 1.3M | 00.00% | Unchanged |
| BNP Paribas Asset Management Holding S.A. |
| 0.03% | — | #46 | $26.5M | 1.3M | $0 | 0 | +1.3M | New Buy |
| Woodline Partners LP |
| 0.07% | 0.13% | #31 | $21.2M | 1.0M | $34.5M | 1.6M | -575,000-36.50% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #102 | $20.5M | 968,346 | $19.7M | 899,146 | +69,200+7.70% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #101 | $18.8M | 886,193 | $18.6M | 851,789 | +34,404+4.04% | Add |
| MetLife Investment Management, LLC |
| 0.08% | 0.01% | #30 | $18.2M | 859,076 | $1.2M | 55,857 | +803,219+1,437.99% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #84 | $16.0M | 756,297 | $15.7M | 716,395 | +39,902+5.57% | Add |
| Pivotal bioVenture Partners Investment Advisor LLC |
| 5.04% | 5.73% | #3 | $15.5M | 732,512 | $16.0M | 732,512 | 00.00% | Unchanged |
| TD ASSET MANAGEMENT INC |
| 0.01% | 0.01% | #55 | $15.2M | 719,272 | $15.2M | 694,934 | +24,338+3.50% | Add |
| NAN FUNG TRINITY (HK) Ltd |
| 1.5% | 1.72% | #6 | $15.1M | 714,553 | $15.6M | 714,553 | 00.00% | Unchanged |
| Candriam S.C.A. |
| 0.07% | 0.06% | #32 | $14.4M | 680,132 | $11.6M | 539,882 | +140,250+25.98% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #136 | $13.7M | 647,888 | $17.1M | 781,607 | -133,719-17.11% | Reduce |
| Parkman Healthcare Partners LLC |
| 1.29% | 0.91% | #8 | $12.6M | 594,202 | $8.8M | 403,487 | +190,715+47.27% | Add |
| MARSHALL WACE, LLP |
| 0.01% | 0.03% | #65 | $10.6M | 500,537 | $32.4M | 1.5M | -980,251-66.20% | Reduce |
| Qube Research & Technologies Ltd |
| 0.01% | <0.01% | #63 | $9.3M | 439,186 | $4.1M | 188,229 | +250,957+133.33% | Add |
| ALERUS FINANCIAL NA |
| 0.36% | — | #17 | $8.1M | 383,421 | $0 | 0 | +383,421 | New Buy |
| Granahan Investment Management, LLC |
| 0.29% | 0.32% | #18 | $8.0M | 378,542 | $6.7M | 307,021 | +71,521+23.30% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #121 | $7.8M | 367,967 | $730,633 | 33,408 | +334,559+1,001.43% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #82 | $7.6M | 359,780 | $7.9M | 362,621 | -2,841-0.78% | Reduce |
| Rock Springs Capital Management LP |
| 0.36% | 0.45% | #16 | $7.4M | 347,666 | $7.6M | 347,666 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #135 | $7.0M | 328,493 | $9.5M | 432,912 | -104,419-24.12% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #137 | $6.4M | 303,279 | $3.8M | 175,697 | +127,582+72.61% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #129 | $6.3M | 298,866 | $6.0M | 276,066 | +22,800+8.26% | Add |
| Atom Investors LP |
| 0.56% | 0.48% | #9 | $6.3M | 297,489 | $6.7M | 306,880 | -9,391-3.06% | Reduce |
| Nuveen, LLC |
| <0.01% | <0.01% | #120 | $6.1M | 288,922 | $6.7M | 305,254 | -16,332-5.35% | Reduce |
| KENNEDY CAPITAL MANAGEMENT LLC |
| 0.1% | 0.13% | #28 | $5.9M | 277,064 | $6.3M | 287,030 | -9,966-3.47% | Reduce |
| Tidal Investments LLC |
| 0.01% | 0.01% | #61 | $5.7M | 268,167 | $6.0M | 275,896 | -7,729-2.80% | Reduce |
| TEMA ETFS LLC |
| 0.18% | 0.41% | #21 | $5.7M | 268,167 | $6.0M | 275,896 | -7,729-2.80% | Reduce |
| Atika Capital Management LLC |
| 0.54% | 0.72% | #10 | $5.6M | 262,900 | $5.7M | 262,900 | 00.00% | Unchanged |
| FIRST TRUST ADVISORS LP |
| <0.01% | — | #88 | $5.6M | 262,823 | $0 | 0 | +262,823 | New Buy |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | <0.01% | #67 | $5.3M | 251,102 | $1.5M | 68,902 | +182,200+264.43% | Add |
