| EcoR1 Capital, LLC |
| 25.86% | 18.55% | #1 | $531.9M | 7.9M | $437.0M | 7.9M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #107 | $124.5M | 1.8M | $93.2M | 1.7M | +162,669+9.67% | Add |
| TANG CAPITAL MANAGEMENT LLC |
| 4.08% | 3.75% | #5 | $89.8M | 1.3M | $73.8M | 1.3M | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #96 | $86.8M | 1.3M | $55.0M | 992,445 | +293,749+29.60% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #119 | $61.2M | 906,233 | $47.3M | 853,151 | +53,082+6.22% | Add |
| Affinity Asset Advisors, LLC |
| 2.52% | 2.69% | #7 | $55.8M | 826,109 | $52.1M | 940,000 | -113,891-12.12% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| 0.02% | 0.01% | #45 | $55.5M | 822,316 | $26.4M | 475,572 | +346,744+72.91% | Add |
| Sanofi |
| 10.39% | 9.04% | #2 | $55.5M | 821,917 | $30.4M | 821,917 | 00.00% | Unchanged |
| Woodline Partners LP |
| 0.15% | 0.07% | #24 | $48.4M | 717,014 | $19.1M | 344,256 | +372,758+108.28% | Add |
| 683 Capital Management, LLC |
| 2.19% | 1.81% | #9 | $44.6M | 660,000 | $34.7M | 625,000 | +35,000+5.60% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #99 | $43.1M | 637,873 | $28.9M | 520,241 | +117,632+22.61% | Add |
| Palo Alto Investors LP |
| 5.95% | 5.41% | #4 | $40.7M | 603,489 | $35.4M | 638,161 | -34,672-5.43% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #86 | $39.4M | 584,070 | $18.5M | 332,743 | +251,327+75.53% | Add |
| First Light Asset Management, LLC |
| 2.39% | 2.81% | #8 | $39.3M | 582,004 | $31.4M | 565,431 | +16,573+2.93% | Add |
| D. E. Shaw & Co., Inc. |
| 0.02% | 0.02% | #49 | $36.4M | 539,666 | $32.1M | 579,296 | -39,630-6.84% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #112 | $35.6M | 527,858 | $28.8M | 519,870 | +7,988+1.54% | Add |
| APIS CAPITAL ADVISORS, LLC |
| 3.27% | 2.04% | #6 | $33.5M | 497,000 | $13.2M | 238,000 | +259,000+108.82% | Add |
| Sofinnova Investments, Inc. |
| 1.72% | 0.52% | #10 | $33.3M | 493,536 | $13.8M | 248,253 | +245,283+98.80% | Add |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.01% | 0.01% | #54 | $33.0M | 488,651 | $27.3M | 492,120 | -3,469-0.70% | Reduce |
| Nuveen, LLC |
| 0.01% | <0.01% | #71 | $28.4M | 420,664 | $17.5M | 316,065 | +104,599+33.09% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #109 | $28.2M | 417,812 | $27.8M | 501,086 | -83,274-16.62% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #90 | $27.9M | 413,673 | $13.4M | 241,150 | +172,523+71.54% | Add |
| FEDERATED HERMES, INC. |
| 0.04% | 0.03% | #38 | $26.4M | 391,667 | $20.2M | 364,121 | +27,546+7.57% | Add |
| Squarepoint Ops LLC |
| 0.02% | 0.02% | #42 | $21.9M | 324,446 | $14.8M | 267,703 | +56,743+21.20% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.02% | #57 | $17.8M | 262,995 | $25.8M | 465,083 | -202,088-43.45% | Reduce |
| FIRST TRUST ADVISORS LP |
| 0.01% | — | #63 | $17.5M | 258,989 | $0 | 0 | +258,989 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #137 | $17.4M | 257,091 | $47.7M | 1.6M | -1.3M-83.48% | Reduce |
| Coppell Advisory Solutions LLC |
| 1.37% | — | #11 | $16.6M | 3,638 | $0 | 0 | +3,638 | New Buy |
| FMR LLC |
| <0.01% | <0.01% | #142 | $16.2M | 240,511 | $26.2M | 472,704 | -232,193-49.12% | Reduce |
| Qube Research & Technologies Ltd |
| 0.01% | 0.02% | #55 | $15.4M | 228,777 | $14.1M | 254,736 | -25,959-10.19% | Reduce |
| HSBC HOLDINGS PLC |
| 0.01% | <0.01% | #75 | $14.9M | 216,949 | $7.1M | 125,717 | +91,232+72.57% | Add |
| Empowered Funds, LLC |
| 0.07% | — | #30 | $13.9M | 206,010 | $0 | 0 | +206,010 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #114 | $13.7M | 202,767 | $10.2M | 183,519 | +19,248+10.49% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #108 | $13.7M | 202,305 | $10.7M | 192,687 | +9,618+4.99% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #128 | $13.6M | 202,056 | $6.7M | 121,103 | +80,953+66.85% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | — | #100 | $12.5M | 185,444 | $0 | 0 | +185,444 | New Buy |
| Greenhaven Road Investment Management, L.P. |
| 7.5% | — | #3 | $11.5M | 171,059 | $0 | 0 | +171,059 | New Buy |
| VICTORY CAPITAL MANAGEMENT INC |
| 0.01% | <0.01% | #73 | $11.4M | 169,227 | $6.0M | 108,203 | +61,024+56.40% | Add |
| MACKENZIE FINANCIAL CORP |
| 0.01% | <0.01% | #64 | $10.2M | 150,979 | $1.9M | 33,720 | +117,259+347.74% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #120 | $9.9M | 146,832 | $4.4M | 79,670 | +67,162+84.30% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #103 | $9.9M | 146,724 | $7.5M | 135,082 | +11,642+8.62% | Add |
| Connor, Clark & Lunn Investment Management Ltd. |
| 0.02% | 0.02% | #48 | $9.5M | 141,026 | $8.8M | 158,562 | -17,536-11.06% | Reduce |
| Ensign Peak Advisors, Inc |
| 0.01% | 0.01% | #59 | $7.2M | 107,096 | $7.0M | 125,633 | -18,537-14.75% | Reduce |
| FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #116 | $7.2M | 106,949 | $3.7M | 65,820 | +41,129+62.49% | Add |
| CITIGROUP INC |
| <0.01% | <0.01% | #102 | $6.7M | 99,114 | $4.1M | 73,406 | +25,708+35.02% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #158 | $6.5M | 96,500 | $2.2M | 39,577 | +56,923+143.83% | Add |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.01% | 0.01% | #65 | $6.3M | 93,732 | $5.2M | 93,732 | 00.00% | Unchanged |
| PRUDENTIAL FINANCIAL INC |
| 0.01% | <0.01% | #74 | $5.8M | 85,932 | $3.6M | 64,050 | +21,882+34.16% | Add |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main |
| <0.01% | — | #82 | $5.7M | 83,942 | $0 | 0 | +83,942 | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #171 | $5.3M | 80,236 | $645,018 | 11,645 | +68,591+589.02% | Add |
