| Bain Capital Life Sciences Investors, LLC |
| 14.74% | 22.93% | #1 | $247.9M | 8.4M | $254.2M | 10.4M | -2.0M-19.14% | Reduce |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.04% | 0.05% | #36 | $230.7M | 7.9M | $291.5M | 12.0M | -4.1M-34.37% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #102 | $152.5M | 5.2M | $35.6M | 1.5M | +3.7M+255.38% | Add |
| FMR LLC |
| 0.01% | 0.01% | #76 | $141.4M | 4.8M | $131.3M | 5.4M | -576,858-10.69% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #83 | $105.2M | 3.6M | $49.8M | 2.0M | +1.5M+75.20% | Add |
| BAMCO INC /NY/ |
| 0.14% | 0.28% | #22 | $94.6M | 3.2M | $93.1M | 3.8M | -602,398-15.74% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #111 | $80.8M | 2.8M | $46.1M | 1.9M | +859,711+45.40% | Add |
| Jupiter Topco LLC |
| 0.03% | — | #41 | $71.0M | 2.4M | $0 | 0 | +2.4M | New Buy |
| Invesco Ltd. |
| 0.01% | 0.01% | #79 | $67.4M | 2.3M | $46.5M | 1.9M | +385,628+20.16% | Add |
| Point72 Asset Management, L.P. |
| 0.06% | 0.02% | #31 | $50.5M | 1.7M | $13.1M | 538,351 | +1.2M+219.73% | Add |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC |
| 0.87% | 0.58% | #10 | $49.7M | 1.7M | $21.7M | 892,093 | +802,558+89.96% | Add |
| ALLIANCEBERNSTEIN L.P. |
| 0.02% | 0.01% | #52 | $46.8M | 1.9M | $35.7M | 1.2M | +699,942+57.17% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #123 | $43.3M | 1.5M | $11.0M | 450,550 | +1.0M+225.36% | Add |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| 0.01% | 0.01% | #68 | $43.0M | 1.5M | $34.4M | 1.4M | +50,822+3.59% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #104 | $39.9M | 1.4M | $13.2M | 541,659 | +818,732+151.15% | Add |
| Nuveen, LLC |
| 0.01% | <0.01% | #59 | $39.7M | 1.4M | $565,405 | 23,239 | +1.3M+5,722.83% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #114 | $31.0M | 1.1M | $25.4M | 755,141 | +299,748+39.69% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #87 | $28.6M | 975,510 | $10.4M | 429,084 | +546,426+127.35% | Add |
| BNP Paribas Asset Management Holding S.A. |
| 0.03% | — | #43 | $27.3M | 931,160 | $0 | 0 | +931,160 | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #61 | $27.1M | 922,893 | $26.6M | 1.1M | -170,524-15.60% | Reduce |
| 12 West Capital Management LP |
| 4.95% | 2.63% | #2 | $26.5M | 902,500 | $15.6M | 640,000 | +262,500+41.02% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #95 | $24.8M | 846,083 | $18.7M | 768,705 | +77,378+10.07% | Add |
| FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #81 | $24.0M | 817,701 | $19.3M | 793,721 | +23,980+3.02% | Add |
| Champlain Investment Partners, LLC |
| 0.55% | 0.18% | #12 | $21.5M | 733,607 | $13.8M | 567,424 | +166,183+29.29% | Add |
| VOYA INVESTMENT MANAGEMENT LLC |
| 0.02% | 0.02% | #49 | $21.5M | 733,183 | $17.7M | 727,667 | +5,516+0.76% | Add |
| NEXT CENTURY GROWTH INVESTORS LLC |
| 1.04% | 1.17% | #8 | $19.7M | 671,404 | $15.9M | 652,969 | +18,435+2.82% | Add |
| NZS Capital, LLC |
| 0.5% | 0.24% | #13 | $19.2M | 656,014 | $7.1M | 290,133 | +365,881+126.11% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #89 | $19.1M | 650,849 | $1.5M | 61,048 | +589,801+966.13% | Add |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 0.25% | 0.3% | #17 | $18.7M | 636,942 | $18.4M | 756,956 | -120,014-15.85% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #116 | $17.8M | 607,387 | $5.4M | 220,540 | +386,847+175.41% | Add |
| Catalio Capital Management, LP |
| 3.21% | 2.05% | #3 | $17.1M | 583,055 | $9.8M | 403,588 | +179,467+44.47% | Add |
| Rock Springs Capital Management LP |
| 0.82% | 0.82% | #11 | $16.8M | 573,500 | $13.9M | 572,500 | +1,000+0.17% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #130 | $16.6M | 567,030 | $2.7M | 111,702 | +455,328+407.63% | Add |
| FRED ALGER MANAGEMENT, LLC |
| 0.05% | 0.07% | #33 | $15.8M | 539,160 | $15.5M | 638,306 | -99,146-15.53% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #109 | $15.8M | 537,902 | $3.9M | 158,338 | +379,564+239.72% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #135 | $15.5M | 441,237 | $10.7M | 446,985 | -5,748-1.29% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.01% | <0.01% | #72 | $15.0M | 511,523 | $8.3M | 342,809 | +168,714+49.22% | Add |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| <0.01% | — | #82 | $14.6M | 498,812 | $0 | 0 | +498,812 | New Buy |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.02% | — | #53 | $11.2M | 382,700 | $0 | 0 | +382,700 | New Buy |
| Alyeska Investment Group, L.P. |
| 0.03% | 0.02% | #45 | $10.3M | 350,000 | $5.5M | 225,000 | +125,000+55.56% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #91 | $8.9M | 303,220 | $5.1M | 208,814 | +94,406+45.21% | Add |
| Walleye Capital LLC |
| 0.03% | <0.01% | #39 | $8.8M | 298,568 | $473,559 | 19,464 | +279,104+1,433.95% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #127 | $8.7M | 297,254 | $3.6M | 149,113 | +148,141+99.35% | Add |
| RTW INVESTMENTS, LP |
| 0.07% | 0.12% | #27 | $8.7M | 295,000 | $12.0M | 495,000 | -200,000-40.40% | Reduce |
| XXEC, Inc. |
| 1.47% | 1.42% | #6 | $8.1M | 278,681 | $8.1M | 278,681 | 00.00% | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #142 | $7.0M | 238,268 | $779,000 | 31,975 | +206,293+645.17% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #118 | $6.9M | 235,809 | $3.7M | 150,457 | +85,352+56.73% | Add |
| Capricorn Investment Group LLC |
| 0.96% | 1.08% | #9 | $6.5M | 256,701 | $6.5M | 256,701 | 00.00% | Unchanged |
| LORD, ABBETT & CO. LLC |
| 0.02% | 0.04% | #50 | $5.9M | 200,536 | $11.0M | 450,364 | -249,828-55.47% | Reduce |
| Lisanti Capital Growth, LLC |
| 1.22% | 0.76% | #7 | $5.6M | 189,675 | $3.0M | 123,805 | +65,870+53.20% | Add |
