| WELLINGTON MANAGEMENT GROUP LLP |
| 0.06% | 0.05% | #59 | $355.1M | 9.5M | $271.5M | 8.6M | +983,195+11.49% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #116 | $260.6M | 7.0M | $170.3M | 5.4M | +1.6M+30.40% | Add |
| Kynam Capital Management, LP |
| 10.95% | 11.43% | #1 | $198.1M | 5.3M | $185.3M | 5.8M | -517,659-8.86% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | 0.01% | #76 | $174.3M | 4.7M | $66.2M | 2.1M | +2.6M+124.57% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #113 | $145.1M | 3.9M | $88.9M | 2.8M | +1.1M+39.09% | Add |
| FMR LLC |
| 0.01% | 0.01% | #98 | $138.5M | 3.7M | $118.9M | 3.7M | -26,160-0.70% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #129 | $128.9M | 3.5M | $93.9M | 3.0M | +503,936+17.02% | Add |
| Deep Track Capital, LP |
| 1.59% | 0.67% | #17 | $109.4M | 2.9M | $40.7M | 1.3M | +1.7M+128.91% | Add |
| Logos Global Management LP |
| 3.36% | 0.71% | #8 | $78.1M | 2.1M | $14.3M | 450,000 | +1.7M+366.67% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #114 | $75.3M | 2.0M | $53.6M | 1.7M | +334,152+19.79% | Add |
| Eversept Partners, LP |
| 3.45% | 2.99% | #7 | $66.5M | 1.8M | $56.7M | 1.8M | -2,075-0.12% | Reduce |
| GOLDMAN SACHS GROUP INC |
| 0.01% | <0.01% | #100 | $60.1M | 1.6M | $31.4M | 988,416 | +626,927+63.43% | Add |
| Commodore Capital LP |
| 2.99% | 4.95% | #10 | $50.2M | 1.4M | $85.5M | 2.7M | -1.3M-49.94% | Reduce |
| Bellevue Group AG |
| 0.94% | 0.91% | #26 | $44.7M | 1.2M | $38.1M | 1.2M | 00.00% | Unchanged |
| BAKER BROS. ADVISORS LP |
| 0.22% | 0.12% | #42 | $44.0M | 1.2M | $21.1M | 665,370 | +517,241+77.74% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.02% | #82 | $43.6M | 1.2M | $39.8M | 1.3M | -82,745-6.60% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #93 | $40.0M | 1.1M | $33.6M | 1.1M | +14,451+1.36% | Add |
| AMERICAN CENTURY COMPANIES INC |
| 0.02% | 0.01% | #77 | $38.8M | 1.0M | $27.2M | 856,310 | +186,085+21.73% | Add |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 0.52% | 0.54% | #34 | $38.6M | 1.0M | $32.9M | 1.0M | 00.00% | Unchanged |
| Novo Holdings A/S |
| 2.22% | 3.08% | #12 | $38.1M | 1.0M | $38.1M | 1.2M | -175,000-14.58% | Reduce |
| Elmind Capital, LP |
| 9.25% | 7.79% | #2 | $36.8M | 990,000 | $27.4M | 865,000 | +125,000+14.45% | Add |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.21% | — | #43 | $36.8M | 989,442 | $0 | 0 | +989,442 | New Buy |
| Fisher Asset Management, LLC |
| 0.01% | 0.01% | #86 | $36.7M | 985,677 | $32.2M | 1.0M | -27,971-2.76% | Reduce |
| Pictet Asset Management Holding SA |
| 0.03% | 0.03% | #67 | $34.1M | 917,408 | $29.3M | 923,696 | -6,288-0.68% | Reduce |
| Foresite Capital Management VI LLC |
| 5.09% | 2.18% | #5 | $32.7M | 879,713 | $10.0M | 315,913 | +563,800+178.47% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #155 | $32.1M | 863,536 | $20.0M | 629,252 | +234,284+37.23% | Add |
| Assenagon Asset Management S.A. |
| 0.04% | 0.01% | #64 | $29.3M | 788,696 | $4.6M | 146,525 | +642,171+438.27% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #121 | $26.8M | 719,647 | $18.3M | 577,267 | +142,380+24.66% | Add |
| Woodline Partners LP |
| 0.08% | 0.06% | #54 | $26.1M | 700,830 | $15.9M | 500,127 | +200,703+40.13% | Add |
| Affinity Asset Advisors, LLC |
| 1.18% | 0.82% | #19 | $26.0M | 700,000 | $15.9M | 500,000 | +200,000+40.00% | Add |
| Rock Springs Capital Management LP |
| 1.27% | 1.22% | #18 | $26.0M | 699,146 | $20.6M | 650,270 | +48,876+7.52% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.02% | <0.01% | #75 | $24.6M | 661,235 | $4.3M | 137,015 | +524,220+382.60% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #120 | $24.4M | 655,954 | $17.3M | 545,486 | +110,468+20.25% | Add |
| ALGERT GLOBAL LLC |
| 0.29% | 0.1% | #37 | $24.1M | 647,836 | $6.8M | 215,159 | +432,677+201.10% | Add |
| ADAR1 Capital Management, LLC |
| 1.06% | 0.8% | #24 | $23.1M | 619,542 | $13.6M | 427,816 | +191,726+44.82% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #154 | $22.6M | 607,195 | $22.5M | 708,647 | -101,452-14.32% | Reduce |
| Ikarian Capital, LLC |
| 2.34% | 1.48% | #11 | $22.0M | 592,500 | $18.2M | 575,247 | +17,253+3.00% | Add |
| PANAGORA ASSET MANAGEMENT INC |
| 0.07% | 0.02% | #57 | $21.3M | 572,538 | $4.5M | 142,327 | +430,211+302.27% | Add |
| Nuveen, LLC |
| 0.01% | <0.01% | #102 | $21.2M | 568,460 | $6.4M | 201,949 | +366,511+181.49% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #108 | $20.6M | 552,973 | $13.6M | 429,597 | +123,376+28.72% | Add |
| 5AM Venture Management, LLC |
| 6.43% | 4.38% | #4 | $18.5M | 497,270 | $15.8M | 497,270 | 00.00% | Unchanged |
| FEDERATED HERMES, INC. |
| 0.03% | — | #70 | $18.3M | 492,893 | $0 | 0 | +492,893 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #139 | $17.9M | 481,997 | $9.4M | 296,970 | +185,027+62.30% | Add |
| Candriam S.C.A. |
| 0.08% | — | #53 | $17.9M | 481,125 | $0 | 0 | +481,125 | New Buy |
| BRAIDWELL LP |
| 0.6% | 1.43% | #31 | $16.2M | 436,646 | $43.0M | 1.4M | -919,436-67.80% | Reduce |
| Redmile Group, LLC |
| 1.08% | 0.55% | #23 | $16.1M | 433,921 | $8.3M | 261,508 | +172,413+65.93% | Add |
| CITIGROUP INC |
| <0.01% | <0.01% | #103 | $15.1M | 404,703 | $6.9M | 217,335 | +187,368+86.21% | Add |
| Palo Alto Investors LP |
| 2.17% | 1.44% | #13 | $14.9M | 399,856 | $9.4M | 296,408 | +103,448+34.90% | Add |
| TSP Capital Management Group, LLC |
| 3.3% | 2.9% | #9 | $13.8M | 371,127 | $11.9M | 375,127 | -4,000-1.07% | Reduce |
| PFM Health Sciences, LP |
| 1.09% | 0.94% | #22 | $12.8M | 342,751 | $10.3M | 324,957 | +17,794+5.48% | Add |
