| FMR LLC |
| 0.02% | 0.02% | #82 | $353.8M | 5.1M | $309.6M | 4.3M | +764,732+17.77% | Add |
| Two Seas Capital LP |
| 4.28% | 1.97% | #5 | $215.9M | 3.1M | $141.0M | 2.0M | +1.1M+57.83% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #127 | $205.4M | 2.9M | $49.8M | 692,650 | +2.2M+324.72% | Add |
| BVF INC/IL |
| 4.27% | 5.87% | #6 | $166.9M | 2.4M | $184.2M | 2.6M | -168,520-6.58% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.01% | 0.01% | #96 | $104.5M | 1.5M | $65.0M | 903,190 | +593,987+65.77% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #142 | $104.5M | 1.5M | $86.1M | 1.2M | +299,794+25.04% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.06% | 0.05% | #63 | $83.9M | 1.2M | $67.0M | 930,741 | +271,263+29.14% | Add |
| Vestal Point Capital, LP |
| 1.63% | 0.57% | #12 | $69.8M | 1.0M | $20.5M | 285,000 | +715,000+250.88% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #123 | $65.4M | 936,560 | $52.9M | 929,151 | +7,409+0.80% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #145 | $63.5M | 909,679 | $17.6M | 244,727 | +664,952+271.71% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #126 | $61.5M | 881,306 | $25.0M | 346,795 | +534,511+154.13% | Add |
| Prosight Management, LP |
| 9.74% | 8.67% | #2 | $56.5M | 810,000 | $52.9M | 735,000 | +75,000+10.20% | Add |
| ARMISTICE CAPITAL, LLC |
| 0.62% | 0.74% | #28 | $50.5M | 724,000 | $41.6M | 578,000 | +146,000+25.26% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.02% | 0.01% | #83 | $45.2M | 648,120 | $29.1M | 404,277 | +243,843+60.32% | Add |
| GILDER GAGNON HOWE & CO LLC |
| 0.43% | 0.23% | #35 | $41.9M | 600,873 | $19.6M | 271,758 | +329,115+121.11% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | 0.01% | #116 | $34.8M | 499,047 | $47.9M | 665,431 | -166,384-25.00% | Reduce |
| BRAIDWELL LP |
| 1.22% | 0.53% | #17 | $33.1M | 473,617 | $16.0M | 222,701 | +250,916+112.67% | Add |
| Sofinnova Investments, Inc. |
| 1.7% | 1.39% | #11 | $32.9M | 471,763 | $36.7M | 509,546 | -37,783-7.42% | Reduce |
| Woodline Partners LP |
| 0.1% | 0.11% | #56 | $32.9M | 470,875 | $29.9M | 415,335 | +55,540+13.37% | Add |
| ORBIMED ADVISORS LLC |
| 0.61% | 0.39% | #29 | $32.5M | 465,346 | $19.8M | 275,000 | +190,346+69.22% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #118 | $29.9M | 428,400 | $23.0M | 320,172 | +108,228+33.80% | Add |
| EMERALD ADVISERS, LLC |
| 0.64% | 0.9% | #26 | $27.2M | 390,158 | $28.4M | 394,604 | -4,446-1.13% | Reduce |
| LORD, ABBETT & CO. LLC |
| 0.08% | 0.1% | #59 | $26.6M | 381,624 | $29.1M | 405,080 | -23,456-5.79% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #164 | $24.3M | 348,540 | $5.2M | 72,491 | +276,049+380.80% | Add |
| DAFNA Capital Management LLC |
| 4.24% | 2.7% | #7 | $22.2M | 318,380 | $11.9M | 165,178 | +153,202+92.75% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #132 | $21.5M | 308,531 | $5.7M | 78,598 | +229,933+292.54% | Add |
| Deep Track Capital, LP |
| 0.3% | — | #40 | $20.9M | 300,000 | $0 | 0 | +300,000 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #131 | $19.9M | 284,971 | $12.1M | 168,007 | +116,964+69.62% | Add |
| 22NW, LP |
| 18.75% | 15.92% | #1 | $19.6M | 281,115 | $20.2M | 281,115 | 00.00% | Unchanged |
| PRIMECAP MANAGEMENT CO/CA/ |
| 0.01% | 0.02% | #87 | $19.0M | 272,850 | $20.1M | 279,150 | -6,300-2.26% | Reduce |
| BARCLAYS PLC |
| <0.01% | <0.01% | #124 | $18.3M | 262,362 | $2.3M | 32,356 | +230,006+710.86% | Add |
| Nearwater Capital Markets, Ltd |
| 0.31% | 0.44% | #38 | $18.3M | 261,500 | $18.8M | 261,500 | 00.00% | Unchanged |
| EMERALD MUTUAL FUND ADVISERS TRUST |
| 0.63% | 0.89% | #27 | $17.8M | 255,587 | $18.4M | 256,106 | -519-0.20% | Reduce |
| ADAR1 Capital Management, LLC |
| 0.79% | 0.68% | #24 | $17.0M | 244,184 | $11.6M | 161,252 | +82,932+51.43% | Add |
| Creek Drive Management Group LLC |
| 8.24% | 2.89% | #3 | $17.0M | 243,000 | $12.7M | 176,400 | +66,600+37.76% | Add |
| SEVEN GRAND MANAGERS, LLC |
| 0.67% | 0.6% | #25 | $16.8M | 240,000 | $9.0M | 125,000 | +115,000+92.00% | Add |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #110 | $16.7M | 239,831 | $6.6M | 91,671 | +148,160+161.62% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #119 | $16.7M | 239,575 | $12.2M | 169,308 | +70,267+41.50% | Add |
| LMR Partners LLP |
| 0.06% | 0.01% | #65 | $16.1M | 230,000 | $3.5M | 48,294 | +181,706+376.25% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #155 | $16.0M | 228,490 | $9.1M | 126,942 | +101,548+80.00% | Add |
| NORGES BANK |
| <0.01% | — | #152 | $15.0M | 215,300 | $0 | 0 | +215,300 | New Buy |
| Bronte Capital Management Pty Ltd. |
| 1.49% | 2.86% | #13 | $13.9M | 198,434 | $28.8M | 400,756 | -202,322-50.49% | Reduce |
| Caption Management, LLC |
| 0.06% | 0.11% | #62 | $13.8M | 197,200 | $18.3M | 255,000 | -57,800-22.67% | Reduce |
| GREAT POINT PARTNERS LLC |
| 2.31% | 5.23% | #10 | $12.2M | 175,000 | $22.8M | 316,453 | -141,453-44.70% | Reduce |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #138 | $11.6M | 165,941 | $9.8M | 136,730 | +29,211+21.36% | Add |
| Quinn Opportunity Partners LLC |
| 0.5% | 0.67% | #31 | $10.7M | 153,076 | $12.9M | 179,247 | -26,171-14.60% | Reduce |
| Rhenman & Partners Asset Management AB |
| 0.93% | 0.52% | #21 | $9.9M | 141,250 | $4.2M | 59,000 | +82,250+139.41% | Add |
| Qube Research & Technologies Ltd |
| 0.01% | 0.03% | #95 | $9.1M | 130,521 | $28.1M | 390,675 | -260,154-66.59% | Reduce |
| Soleus Capital Management, L.P. |
| 0.31% | — | #39 | $9.0M | 128,362 | $0 | 0 | +128,362 | New Buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. |
| 0.47% | 0.75% | #33 | $8.6M | 122,767 | $8.8M | 122,326 | +441+0.36% | Add |
