| BAKER BROS. ADVISORS LP |
| 2.39% | 3.96% | #2 | $477.7M | 32.8M | $690.0M | 36.4M | -3.6M-9.91% | Reduce |
| FMR LLC |
| 0.01% | 0.01% | #81 | $146.3M | 10.0M | $205.8M | 10.9M | -809,252-7.46% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #95 | $139.0M | 9.5M | $133.3M | 7.0M | +2.5M+35.69% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #124 | $138.8M | 9.5M | $183.0M | 9.7M | -124,717-1.29% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #132 | $83.6M | 5.7M | $108.3M | 5.7M | +22,682+0.40% | Add |
| UBS Group AG |
| 0.01% | 0.01% | #67 | $77.3M | 5.3M | $70.2M | 3.7M | +1.6M+43.40% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | 0.01% | #107 | $73.5M | 5.0M | $99.2M | 5.2M | -191,062-3.65% | Reduce |
| GOLDMAN SACHS GROUP INC |
| 0.01% | <0.01% | #85 | $65.8M | 4.5M | $5.9M | 310,728 | +4.2M+1,352.52% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.02% | #86 | $56.7M | 3.9M | $156.9M | 8.3M | -4.4M-52.96% | Reduce |
| Point72 Asset Management, L.P. |
| 0.06% | 0.02% | #30 | $53.9M | 3.7M | $15.2M | 801,086 | +2.9M+361.60% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #115 | $50.0M | 3.4M | $62.9M | 3.3M | +111,409+3.36% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #90 | $41.9M | 2.9M | $20.1M | 1.1M | +1.8M+171.00% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | 0.01% | #114 | $35.0M | 2.4M | $45.7M | 2.4M | -9,694-0.40% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | <0.01% | #61 | $34.2M | 2.3M | $2.4M | 126,273 | +2.2M+1,760.32% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.04% | — | #37 | $29.0M | 2.0M | $0 | 0 | +2.0M | New Buy |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.03% | 0.01% | #44 | $27.7M | 1.9M | $10.4M | 548,335 | +1.4M+247.28% | Add |
| Squarepoint Ops LLC |
| 0.03% | 0.01% | #49 | $26.7M | 1.8M | $11.6M | 613,877 | +1.2M+198.37% | Add |
| Aberdeen Group plc |
| 0.03% | 0.02% | #43 | $24.7M | 1.7M | $12.6M | 665,364 | +1.0M+154.54% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #140 | $21.1M | 1.5M | $39.8M | 1.9M | -476,809-24.75% | Reduce |
| NORGES BANK |
| <0.01% | <0.01% | #126 | $20.1M | 1.4M | $19.6M | 1.0M | +364,545+35.81% | Add |
| Logos Global Management LP |
| 0.85% | — | #8 | $19.7M | 1.4M | $0 | 0 | +1.4M | New Buy |
| Octagon Capital Advisors LP |
| 1.64% | — | #6 | $18.2M | 1.3M | $0 | 0 | +1.3M | New Buy |
| D. E. Shaw & Co., Inc. |
| 0.01% | 0.03% | #71 | $18.1M | 1.2M | $42.5M | 2.2M | -998,673-44.54% | Reduce |
| Kynam Capital Management, LP |
| 0.97% | — | #7 | $17.5M | 1.2M | $0 | 0 | +1.2M | New Buy |
| Pictet Asset Management Holding SA |
| 0.02% | 0.03% | #56 | $16.4M | 1.1M | $24.0M | 1.3M | -188,880-14.27% | Reduce |
| DIADEMA PARTNERS LP |
| 2.01% | — | #4 | $16.3M | 1.1M | $0 | 0 | +1.1M | New Buy |
| LMR Partners LLP |
| 0.06% | 0.03% | #32 | $14.8M | 1.0M | $13.0M | 684,622 | +332,055+48.50% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #131 | $14.2M | 976,851 | $18.2M | 960,867 | +15,984+1.66% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #109 | $14.1M | 966,585 | $17.7M | 934,394 | +32,191+3.45% | Add |
| APEIRON CAPITAL Ltd |
| 9% | 23.21% | #1 | $14.0M | 961,866 | $24.8M | 1.3M | -347,275-26.53% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #152 | $12.6M | 864,983 | $11.4M | 598,692 | +266,291+44.48% | Add |
| SCHRODER INVESTMENT MANAGEMENT GROUP |
| 0.01% | <0.01% | #72 | $12.0M | 835,963 | $4.3M | 251,391 | +584,572+232.53% | Add |
| CITIGROUP INC |
| <0.01% | <0.01% | #101 | $10.8M | 744,000 | $6.6M | 349,933 | +394,067+112.61% | Add |
| Rock Springs Capital Management LP |
| 0.51% | 0.79% | #9 | $10.4M | 715,000 | $13.5M | 710,000 | +5,000+0.70% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.02% | #74 | $10.2M | 696,714 | $18.6M | 981,185 | -284,471-28.99% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #145 | $9.2M | 633,794 | $11.0M | 581,600 | +52,194+8.97% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #156 | $9.2M | 633,700 | $5.7M | 299,900 | +333,800+111.30% | Add |
| MARSHALL WACE, LLP |
| 0.01% | 0.01% | #77 | $8.4M | 577,190 | $9.0M | 475,241 | +101,949+21.45% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #113 | $7.9M | 542,178 | $8.1M | 443,757 | +98,421+22.18% | Add |
| Candriam S.C.A. |
| 0.04% | 0.05% | #42 | $7.8M | 532,432 | $9.5M | 540,662 | -8,230-1.52% | Reduce |
| Caption Management, LLC |
| 0.04% | 0.03% | #41 | $7.7M | 528,700 | $4.9M | 260,000 | +268,700+103.35% | Add |
| Elmind Capital, LP |
| 1.81% | — | #5 | $7.2M | 493,820 | $0 | 0 | +493,820 | New Buy |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #141 | $6.4M | 441,934 | $6.9M | 362,858 | +79,076+21.79% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #146 | $6.3M | 431,299 | $7.7M | 404,679 | +26,620+6.58% | Add |
| WORLDQUANT MILLENNIUM ADVISORS LLC |
| 0.02% | <0.01% | #51 | $6.3M | 431,028 | $1.1M | 58,272 | +372,756+639.68% | Add |
| TD ASSET MANAGEMENT INC |
| 0.01% | 0.01% | #87 | $6.2M | 426,084 | $18.1M | 956,894 | -530,810-55.47% | Reduce |
| Invesco Ltd. |
| <0.01% | <0.01% | #170 | $6.1M | 416,847 | $10.0M | 526,103 | -109,256-20.77% | Reduce |
| Jump Financial, LLC |
| 0.05% | 0.03% | #35 | $5.7M | 389,618 | $2.2M | 115,738 | +273,880+236.64% | Add |
| QVT Financial LP |
| 0.31% | 0.5% | #13 | $5.3M | 360,524 | $6.8M | 360,524 | 00.00% | Unchanged |
| Ghisallo Capital Management LLC |
| 0.03% | — | #48 | $5.1M | 350,000 | $0 | 0 | +350,000 | New Buy |
