| BlackRock, Inc. |
| <0.01% | <0.01% | #108 | $246.6M | 5.7M | $204.7M | 5.1M | +659,658+12.96% | Add |
| Avoro Capital Advisors LLC |
| 2.21% | 2.33% | #11 | $245.6M | 5.7M | $236.9M | 5.9M | -165,000-2.80% | Reduce |
| STATE STREET CORP |
| 0.01% | <0.01% | #94 | $178.0M | 4.1M | $135.3M | 3.4M | +785,148+23.34% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | 0.02% | #69 | $172.2M | 4.0M | $184.0M | 4.6M | -561,094-12.27% | Reduce |
| Deep Track Capital, LP |
| 2.5% | 2.7% | #10 | $171.6M | 4.0M | $165.2M | 4.1M | -106,067-2.58% | Reduce |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 1.75% | 1.77% | #12 | $168.1M | 3.9M | $149.7M | 3.7M | +194,300+5.22% | Add |
| Kynam Capital Management, LP |
| 6.85% | 8.43% | #1 | $124.0M | 2.9M | $136.7M | 3.4M | -508,165-14.95% | Reduce |
| MORGAN STANLEY |
| 0.01% | <0.01% | #89 | $120.1M | 2.8M | $8.0M | 274,523 | +2.5M+919.75% | Add |
| Sofinnova Investments, Inc. |
| 6.2% | 4.27% | #2 | $119.9M | 2.8M | $112.4M | 2.8M | 00.00% | Unchanged |
| FMR LLC |
| 0.01% | 0.01% | #97 | $119.0M | 2.8M | $107.7M | 2.7M | +97,648+3.65% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #123 | $118.2M | 2.8M | $108.0M | 2.7M | +71,806+2.68% | Add |
| Eversept Partners, LP |
| 4.93% | 4.61% | #3 | $94.9M | 2.2M | $87.4M | 2.2M | +39,484+1.82% | Add |
| Logos Global Management LP |
| 4.06% | — | #6 | $94.4M | 2.2M | $0 | 0 | +2.2M | New Buy |
| Integral Health Asset Management, LLC |
| 2.97% | 3.08% | #8 | $75.1M | 1.8M | $64.4M | 1.6M | +150,000+9.38% | Add |
| Bellevue Group AG |
| 1.54% | 1.64% | #14 | $73.4M | 1.7M | $68.8M | 1.7M | +37+0.00% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #106 | $72.6M | 1.7M | $63.2M | 1.6M | +122,365+7.79% | Add |
| ALLIANCEBERNSTEIN L.P. |
| 0.02% | 0.02% | #66 | $64.0M | 1.6M | $66.6M | 1.3M | +276,801+21.06% | Add |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #98 | $59.3M | 1.4M | $45.6M | 1.1M | +246,866+21.77% | Add |
| FRONTIER CAPITAL MANAGEMENT CO LLC |
| 0.52% | 0.23% | #26 | $55.6M | 1.3M | $22.2M | 551,493 | +743,912+134.89% | Add |
| Pictet Asset Management Holding SA |
| 0.05% | 0.04% | #52 | $53.6M | 1.2M | $42.3M | 1.1M | +197,831+18.81% | Add |
| DEUTSCHE BANK AG\ |
| 0.01% | 0.01% | #77 | $47.3M | 1.1M | $21.4M | 532,466 | +569,640+106.98% | Add |
| Qube Research & Technologies Ltd |
| 0.04% | 0.02% | #56 | $46.5M | 1.1M | $21.8M | 541,799 | +541,380+99.92% | Add |
| Woodline Partners LP |
| 0.13% | 0.15% | #38 | $43.0M | 1.0M | $40.3M | 1.0M | 00.00% | Unchanged |
| AMERICAN CENTURY COMPANIES INC |
| 0.02% | 0.02% | #72 | $37.2M | 866,243 | $29.3M | 728,330 | +137,913+18.94% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #147 | $27.6M | 642,873 | $22.2M | 552,971 | +89,902+16.26% | Add |
| VOYA INVESTMENT MANAGEMENT LLC |
| 0.02% | 0.01% | #65 | $27.6M | 642,562 | $11.7M | 290,476 | +352,086+121.21% | Add |
| GREAT POINT PARTNERS LLC |
| 4.87% | 1.84% | #4 | $25.8M | 600,836 | $8.0M | 199,348 | +401,488+201.40% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #138 | $25.3M | 590,103 | $23.7M | 589,684 | +419+0.07% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #117 | $24.9M | 581,126 | $20.9M | 519,445 | +61,681+11.87% | Add |
| BRAIDWELL LP |
| 0.9% | 0.7% | #20 | $24.2M | 564,724 | $21.1M | 523,824 | +40,900+7.81% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #113 | $23.4M | 545,013 | $21.1M | 524,562 | +20,451+3.90% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #103 | $22.7M | 527,853 | $11.2M | 278,765 | +249,088+89.35% | Add |
| SCHRODER INVESTMENT MANAGEMENT GROUP |
| 0.02% | 0.02% | #73 | $22.0M | 510,787 | $18.5M | 484,381 | +26,406+5.45% | Add |
| Davern Capital Partners, LP |
| 3.65% | — | #7 | $21.4M | 498,832 | $0 | 0 | +498,832 | New Buy |
| Candriam S.C.A. |
| 0.09% | 0.11% | #43 | $20.1M | 468,099 | $22.8M | 449,554 | +18,545+4.13% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #101 | $20.0M | 465,807 | $17.8M | 441,511 | +24,296+5.50% | Add |
| Elmind Capital, LP |
| 4.71% | 5.51% | #5 | $18.7M | 436,518 | $19.4M | 482,500 | -45,982-9.53% | Reduce |
| Rock Springs Capital Management LP |
| 0.9% | 1.19% | #21 | $18.3M | 427,584 | $20.3M | 503,585 | -76,001-15.09% | Reduce |
| Ikarian Capital, LLC |
| 1.74% | 0.89% | #13 | $16.4M | 381,700 | $10.9M | 271,700 | +110,000+40.49% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.02% | #67 | $16.1M | 374,951 | $16.9M | 419,570 | -44,619-10.63% | Reduce |
| ORBIMED ADVISORS LLC |
| 0.3% | 0.29% | #32 | $15.9M | 369,596 | $14.9M | 369,596 | 00.00% | Unchanged |
| TimesSquare Capital Management, LLC |
| 0.23% | 0.16% | #33 | $15.6M | 364,557 | $9.4M | 232,463 | +132,094+56.82% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #152 | $13.0M | 303,737 | $12.4M | 308,120 | -4,383-1.42% | Reduce |
| ARMISTICE CAPITAL, LLC |
| 0.16% | 0.21% | #37 | $12.9M | 300,000 | $12.0M | 298,164 | +1,836+0.62% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #116 | $12.8M | 298,410 | $16.0M | 398,602 | -100,192-25.14% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.02% | 0.03% | #71 | $12.0M | 279,528 | $18.4M | 457,300 | -177,772-38.87% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #104 | $12.0M | 278,658 | $11.8M | 293,497 | -14,839-5.06% | Reduce |
| CITIGROUP INC |
| <0.01% | <0.01% | #107 | $11.4M | 266,758 | $10.1M | 249,969 | +16,789+6.72% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #142 | $10.9M | 254,182 | $7.6M | 187,887 | +66,295+35.28% | Add |
| Affinity Asset Advisors, LLC |
| 0.48% | 0.52% | #27 | $10.7M | 250,000 | $10.1M | 250,000 | 00.00% | Unchanged |
