| ORBIMED ADVISORS LLC |
| 11.9% | 9.69% | #2 | $630.5M | 15.5M | $488.8M | 15.5M | 00.00% | Unchanged |
| Paradigm Biocapital Advisors LP |
| 7.77% | 4.74% | #3 | $415.1M | 10.2M | $232.0M | 7.4M | +2.9M+38.70% | Add |
| RA CAPITAL MANAGEMENT, L.P. |
| 2.96% | 3.48% | #12 | $341.0M | 8.4M | $328.5M | 10.4M | -2.0M-19.52% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #101 | $268.4M | 6.6M | $203.9M | 6.5M | +133,345+2.06% | Add |
| Jupiter Topco LLC |
| 0.1% | — | #44 | $246.9M | 6.1M | $0 | 0 | +6.1M | New Buy |
| FMR LLC |
| 0.01% | <0.01% | #78 | $223.0M | 5.5M | $32.0M | 1.0M | +4.5M+439.71% | Add |
| Novo Holdings A/S |
| 12.66% | 13.65% | #1 | $217.4M | 5.4M | $168.5M | 5.4M | 00.00% | Unchanged |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 1.11% | 1.04% | #22 | $192.1M | 4.7M | $141.1M | 4.5M | +250,681+5.60% | Add |
| PERCEPTIVE ADVISORS LLC |
| 2.67% | 2.72% | #14 | $177.7M | 4.4M | $139.4M | 4.4M | -50,000-1.13% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #109 | $156.9M | 3.9M | $119.3M | 3.8M | +72,509+1.91% | Add |
| BAKER BROS. ADVISORS LP |
| 0.75% | 1.19% | #28 | $150.4M | 3.7M | $207.1M | 6.6M | -2.9M-43.71% | Reduce |
| Siren, L.L.C. |
| 2.62% | 3.87% | #15 | $129.4M | 3.2M | $139.6M | 4.4M | -1.2M-28.12% | Reduce |
| Cormorant Asset Management, LP |
| 5.18% | 5.16% | #5 | $102.0M | 2.5M | $102.7M | 3.3M | -750,000-23.01% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #91 | $88.3M | 2.2M | $56.4M | 1.8M | +384,232+21.47% | Add |
| Integral Health Asset Management, LLC |
| 3.21% | 2.41% | #9 | $81.3M | 2.0M | $50.4M | 1.6M | +400,000+25.00% | Add |
| BRAIDWELL LP |
| 3% | 2.47% | #10 | $81.1M | 2.0M | $73.9M | 2.3M | -350,618-14.94% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #97 | $79.2M | 1.9M | $14.1M | 869,678 | +1.1M+124.06% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #126 | $74.3M | 1.8M | $54.1M | 1.7M | +111,104+6.47% | Add |
| ALLIANCEBERNSTEIN L.P. |
| 0.02% | 0.01% | #66 | $66.7M | 2.1M | $42.7M | 1.7M | +396,855+23.04% | Add |
| MPM BioImpact LLC |
| 4.02% | 4.04% | #6 | $65.9M | 1.6M | $52.3M | 1.7M | -39,916-2.40% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #99 | $63.3M | 1.6M | $41.8M | 1.3M | +230,900+17.40% | Add |
| Qube Research & Technologies Ltd |
| 0.05% | 0.03% | #51 | $50.9M | 1.3M | $26.0M | 825,910 | +426,597+51.65% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #79 | $46.3M | 1.1M | $38.4M | 1.2M | -79,991-6.56% | Reduce |
| AMERICAN CENTURY COMPANIES INC |
| 0.02% | 0.02% | #69 | $45.8M | 1.1M | $36.1M | 1.1M | -20,098-1.75% | Reduce |
| First Light Asset Management, LLC |
| 2.7% | 2.83% | #13 | $44.5M | 1.1M | $31.6M | 1.0M | +93,325+9.32% | Add |
| VICTORY CAPITAL MANAGEMENT INC |
| 0.02% | 0.02% | #68 | $36.7M | 902,870 | $24.9M | 789,043 | +113,827+14.43% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #111 | $33.2M | 816,518 | $2.2M | 69,427 | +747,091+1,076.08% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #140 | $32.0M | 786,456 | $17.6M | 557,260 | +229,196+41.13% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #115 | $27.3M | 671,270 | $18.2M | 576,556 | +94,714+16.43% | Add |
| Aberdeen Group plc |
| 0.04% | 0.04% | #56 | $26.3M | 647,926 | $26.0M | 826,059 | -178,133-21.56% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #108 | $25.2M | 620,532 | $18.8M | 596,310 | +24,222+4.06% | Add |
| Tyro Capital Management LLC |
| 5.59% | — | #4 | $24.9M | 612,965 | $0 | 0 | +612,965 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #129 | $24.4M | 599,469 | $19.8M | 629,820 | -30,351-4.82% | Reduce |
| Parkman Healthcare Partners LLC |
| 2.4% | 1.05% | #16 | $23.4M | 577,036 | $10.2M | 322,828 | +254,208+78.74% | Add |
| Artisan Partners Limited Partnership |
| 0.04% | 0.03% | #55 | $23.4M | 574,925 | $20.8M | 659,067 | -84,142-12.77% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #89 | $22.3M | 548,285 | $16.4M | 521,726 | +26,559+5.09% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #124 | $21.6M | 530,807 | $15.2M | 483,732 | +47,075+9.73% | Add |
| NORGES BANK |
| <0.01% | <0.01% | #130 | $20.7M | 510,140 | $1.1M | 47,755 | +462,385+968.24% | Add |
| Opaleye Management Inc. |
| 1.84% | 2.07% | #17 | $20.3M | 500,000 | $15.8M | 500,000 | 00.00% | Unchanged |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.03% | — | #62 | $18.8M | 462,000 | $0 | 0 | +462,000 | New Buy |
| Soleus Capital Management, L.P. |
| 0.63% | 1.85% | #31 | $18.3M | 450,889 | $45.7M | 1.4M | -999,026-68.90% | Reduce |
| Nuveen, LLC |
| <0.01% | <0.01% | #100 | $16.8M | 414,706 | $10.6M | 335,783 | +78,923+23.50% | Add |
| Sofinnova Investments, Inc. |
| 0.8% | 0.46% | #26 | $15.5M | 380,923 | $12.2M | 386,498 | -5,575-1.44% | Reduce |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND |
| 0.02% | 0.02% | #71 | $13.6M | 334,014 | $12.7M | 404,200 | -70,186-17.36% | Reduce |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #106 | $12.9M | 317,565 | $619,857 | 19,678 | +297,887+1,513.81% | Add |
| Squadron Capital Management LLC |
| 3.66% | 4.04% | #8 | $11.8M | 290,000 | $11.0M | 350,000 | -60,000-17.14% | Reduce |
| Universal- Beteiligungs- und Servicegesellschaft mbH |
| 0.02% | 0.01% | #72 | $11.5M | 283,333 | $8.9M | 283,312 | +21+0.01% | Add |
| DIADEMA PARTNERS LP |
| 1.37% | 1.14% | #20 | $11.1M | 272,214 | $6.7M | 212,500 | +59,714+28.10% | Add |
| PRUDENTIAL FINANCIAL INC |
| 0.01% | <0.01% | #75 | $10.6M | 260,725 | $334,058 | 10,605 | +250,120+2,358.51% | Add |
| KENNEDY CAPITAL MANAGEMENT LLC |
| 0.18% | 0.18% | #39 | $10.4M | 256,608 | $8.3M | 264,204 | -7,596-2.88% | Reduce |
