| FMR LLC |
| 0.02% | 0.02% | #72 | $358.0M | 4.9M | $357.2M | 5.6M | -692,421-12.39% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #105 | $180.5M | 2.5M | $145.4M | 2.3M | +194,068+8.53% | Add |
| RA CAPITAL MANAGEMENT, L.P. |
| 1.56% | 1.66% | #17 | $179.2M | 2.5M | $156.7M | 2.5M | 00.00% | Unchanged |
| JPMORGAN CHASE & CO |
| 0.01% | 0.01% | #84 | $139.9M | 1.9M | $83.4M | 1.4M | +504,315+36.77% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.01% | #75 | $137.2M | 1.9M | $99.1M | 1.5M | +326,049+21.04% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.02% | 0.02% | #66 | $127.4M | 1.7M | $111.0M | 1.7M | +5,975+0.34% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #100 | $120.6M | 1.6M | $108.6M | 1.7M | -49,408-2.91% | Reduce |
| Vestal Point Capital, LP |
| 2.65% | 1.25% | #10 | $113.4M | 1.6M | $44.8M | 700,000 | +850,000+121.43% | Add |
| Atlas Venture Life Science Advisors, LLC |
| 12.56% | 12.25% | #1 | $110.7M | 1.5M | $96.8M | 1.5M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #117 | $100.1M | 1.4M | $87.9M | 1.4M | -6,403-0.47% | Reduce |
| Frazier Life Sciences Management, L.P. |
| 2.16% | 2.23% | #13 | $99.1M | 1.4M | $86.6M | 1.4M | 00.00% | Unchanged |
| TCG Crossover Management, LLC |
| 2.36% | 2.45% | #11 | $98.1M | 1.3M | $85.8M | 1.3M | 00.00% | Unchanged |
| BVF INC/IL |
| 2.16% | 2.59% | #14 | $84.4M | 1.2M | $81.4M | 1.3M | -118,700-9.33% | Reduce |
| Woodline Partners LP |
| 0.22% | 0.23% | #34 | $70.1M | 958,281 | $61.3M | 958,281 | 00.00% | Unchanged |
| Siren, L.L.C. |
| 1.31% | 1.75% | #18 | $65.0M | 888,401 | $63.2M | 988,401 | -100,000-10.12% | Reduce |
| Logos Global Management LP |
| 2.76% | 1.79% | #9 | $64.0M | 875,000 | $35.8M | 560,000 | +315,000+56.25% | Add |
| Opaleye Management Inc. |
| 5.66% | 3.55% | #3 | $62.5M | 855,000 | $26.9M | 421,000 | +434,000+103.09% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #102 | $57.8M | 789,724 | $47.6M | 744,222 | +45,502+6.11% | Add |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.5% | 0.5% | #26 | $48.1M | 657,000 | $42.0M | 657,000 | 00.00% | Unchanged |
| DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #85 | $41.6M | 569,018 | $25.2M | 394,447 | +174,571+44.26% | Add |
| Bellevue Group AG |
| 0.86% | 0.7% | #19 | $41.0M | 560,000 | $29.4M | 459,314 | +100,686+21.92% | Add |
| Saturn V Capital Management LP |
| 5.5% | 5.21% | #4 | $38.4M | 524,730 | $28.8M | 449,926 | +74,804+16.63% | Add |
| ARMISTICE CAPITAL, LLC |
| 0.41% | 0.61% | #28 | $33.6M | 460,000 | $34.3M | 536,000 | -76,000-14.18% | Reduce |
| JENNISON ASSOCIATES LLC |
| 0.02% | 0.03% | #68 | $32.1M | 439,520 | $39.0M | 610,382 | -170,862-27.99% | Reduce |
| Aberdeen Group plc |
| 0.04% | 0.04% | #52 | $32.0M | 438,174 | $24.0M | 375,614 | +62,560+16.66% | Add |
| Palo Alto Investors LP |
| 4.45% | 3.93% | #6 | $30.5M | 416,646 | $25.7M | 401,719 | +14,927+3.72% | Add |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 0.39% | 0.42% | #29 | $28.9M | 395,651 | $25.3M | 395,572 | +79+0.02% | Add |
| Pictet Asset Management Holding SA |
| 0.03% | 0.03% | #60 | $28.2M | 385,375 | $24.7M | 387,005 | -1,630-0.42% | Reduce |
| Assenagon Asset Management S.A. |
| 0.04% | 0.05% | #57 | $28.1M | 384,158 | $34.9M | 546,247 | -162,089-29.67% | Reduce |
| LOOMIS SAYLES & CO L P |
| 0.04% | 0.03% | #56 | $27.9M | 381,864 | $20.3M | 317,222 | +64,642+20.38% | Add |
| Foresite Capital Management V, LLC |
| 7.55% | 8.83% | #2 | $27.4M | 374,069 | $23.9M | 374,069 | 00.00% | Unchanged |
| ORBIMED ADVISORS LLC |
| 0.49% | 1.35% | #27 | $26.2M | 357,535 | $68.3M | 1.1M | -710,015-66.51% | Reduce |
| BAKER BROS. ADVISORS LP |
| 0.13% | 0.13% | #38 | $25.6M | 349,657 | $22.4M | 349,657 | 00.00% | Unchanged |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #138 | $20.6M | 281,937 | $15.8M | 247,338 | +34,599+13.99% | Add |
| Octagon Capital Advisors LP |
| 1.78% | 1.91% | #15 | $19.7M | 270,000 | $17.3M | 270,000 | 00.00% | Unchanged |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #116 | $19.4M | 264,990 | $15.8M | 247,195 | +17,795+7.20% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #112 | $18.8M | 257,382 | $16.1M | 251,195 | +6,187+2.46% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #118 | $17.7M | 242,308 | $8.4M | 131,130 | +111,178+84.78% | Add |
| Checkpoint Capital L.P. |
| 4.51% | 6.58% | #5 | $17.6M | 240,125 | $18.3M | 286,661 | -46,536-16.23% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #99 | $16.5M | 225,198 | $13.9M | 217,436 | +7,762+3.57% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #114 | $15.0M | 204,727 | $13.1M | 204,968 | -241-0.12% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.01% | <0.01% | #88 | $13.5M | 184,695 | $8.2M | 127,737 | +56,958+44.59% | Add |
| Catalio Capital Management, LP |
| 2.19% | 1.64% | #12 | $11.7M | 159,384 | $7.9M | 122,978 | +36,406+29.60% | Add |
| Caption Management, LLC |
| 0.05% | 0.11% | #49 | $11.0M | 150,000 | $19.2M | 300,000 | -150,000-50.00% | Reduce |
| Sofinnova Investments, Inc. |
| 0.55% | 0.19% | #25 | $10.7M | 146,239 | $5.0M | 78,320 | +67,919+86.72% | Add |
| Bain Capital Life Sciences Investors, LLC |
| 0.61% | 0.81% | #23 | $10.3M | 141,234 | $9.0M | 141,234 | 00.00% | Unchanged |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | — | #86 | $10.0M | 136,750 | $0 | 0 | +136,750 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #156 | $9.9M | 135,111 | $10.7M | 166,775 | -31,664-18.99% | Reduce |
| Alyeska Investment Group, L.P. |
| 0.02% | 0.02% | #64 | $9.1M | 125,000 | $8.0M | 125,000 | 00.00% | Unchanged |
| Ensign Peak Advisors, Inc |
| 0.01% | 0.02% | #74 | $8.9M | 122,111 | $12.2M | 191,487 | -69,376-36.23% | Reduce |
