| RA CAPITAL MANAGEMENT, L.P. |
| 23.83% | 24.92% | #1 | $2.74B | 10.3M | $2.35B | 10.3M | 00.00% | Unchanged |
| T. Rowe Price Investment Management, Inc. |
| 1.18% | 0.97% | #30 | $1.80B | 6.8M | $1.41B | 6.2M | +592,804+9.62% | Add |
| Avoro Capital Advisors LLC |
| 12.24% | 11.39% | #4 | $1.36B | 5.1M | $1.16B | 5.1M | +48,611+0.96% | Add |
| WESTFIELD CAPITAL MANAGEMENT CO LP |
| 4.18% | 4.62% | #10 | $1.28B | 4.8M | $1.10B | 4.8M | -15,173-0.32% | Reduce |
| Jupiter Topco LLC |
| 0.4% | — | #46 | $973.4M | 3.6M | $0 | 0 | +3.6M | New Buy |
| FMR LLC |
| 0.04% | 0.05% | #116 | $945.7M | 3.5M | $886.7M | 3.9M | -331,026-8.54% | Reduce |
| Artisan Partners Limited Partnership |
| 1.11% | 1.19% | #31 | $702.5M | 2.6M | $738.8M | 3.2M | -596,164-18.46% | Reduce |
| BlackRock, Inc. |
| 0.01% | <0.01% | #183 | $589.9M | 2.2M | $151.2M | 661,054 | +1.6M+234.59% | Add |
| Capital International Investors |
| 0.11% | 0.11% | #84 | $530.4M | 2.0M | $448.0M | 2.0M | +29,771+1.52% | Add |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.16% | 0.14% | #67 | $500.1M | 1.9M | $425.6M | 1.9M | +14,632+0.79% | Add |
| FRANKLIN RESOURCES INC |
| 0.1% | 0.1% | #87 | $496.8M | 1.9M | $469.3M | 2.1M | -189,445-9.23% | Reduce |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.07% | 0.08% | #102 | $413.1M | 1.5M | $402.0M | 1.8M | -208,997-11.89% | Reduce |
| AMERICAN CENTURY COMPANIES INC |
| 0.17% | 0.16% | #66 | $373.6M | 1.4M | $319.6M | 1.4M | +3,456+0.25% | Add |
| PERCEPTIVE ADVISORS LLC |
| 4.66% | 6.84% | #9 | $310.4M | 1.2M | $350.3M | 1.5M | -367,700-24.01% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.03% | 0.04% | #127 | $299.4M | 1.1M | $350.0M | 1.5M | -407,816-26.65% | Reduce |
| Capital World Investors |
| 0.03% | 0.03% | #128 | $241.7M | 906,081 | $206.0M | 900,517 | +5,564+0.62% | Add |
| PRINCIPAL FINANCIAL GROUP INC |
| 0.11% | 0.11% | #80 | $233.0M | 873,502 | $205.0M | 896,397 | -22,895-2.55% | Reduce |
| Polar Capital Holdings Plc |
| 0.39% | 0.53% | #47 | $164.5M | 616,908 | $149.1M | 651,712 | -34,804-5.34% | Reduce |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #167 | $149.2M | 559,534 | $129.5M | 566,192 | -6,658-1.18% | Reduce |
| MORGAN STANLEY |
| 0.01% | <0.01% | #186 | $145.2M | 544,393 | $80.9M | 406,761 | +137,632+33.84% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #206 | $137.1M | 513,969 | $20.0M | 87,334 | +426,635+488.51% | Add |
| Invesco Ltd. |
| 0.01% | 0.01% | #182 | $110.5M | 414,196 | $82.8M | 362,109 | +52,087+14.38% | Add |
| CITADEL ADVISORS LLC |
| 0.01% | <0.01% | #172 | $108.5M | 406,789 | $15.5M | 67,600 | +339,189+501.76% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #196 | $107.5M | 403,151 | $16.7M | 72,941 | +330,210+452.71% | Add |
| UBS Group AG |
| 0.01% | 0.01% | #166 | $107.2M | 401,881 | $47.4M | 207,339 | +194,542+93.83% | Add |
| ALLIANCEBERNSTEIN L.P. |
| 0.04% | 0.02% | #120 | $106.5M | 399,292 | $59.3M | 278,203 | +121,089+43.53% | Add |
| Vestal Point Capital, LP |
| 2.34% | 2.4% | #19 | $100.0M | 375,000 | $85.8M | 375,000 | 00.00% | Unchanged |
| JPMORGAN CHASE & CO |
| 0.01% | 0.01% | #197 | $97.0M | 367,781 | $117.8M | 539,434 | -171,653-31.82% | Reduce |
| FIL Ltd |
| 0.07% | 0.08% | #103 | $92.2M | 345,567 | $102.3M | 447,421 | -101,854-22.76% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| 0.03% | 0.02% | #126 | $87.7M | 328,708 | $43.2M | 189,027 | +139,681+73.89% | Add |
| AMERIPRISE FINANCIAL INC |
| 0.02% | 0.05% | #147 | $85.5M | 320,514 | $203.1M | 887,966 | -567,452-63.90% | Reduce |
| Bank of New York Mellon Corp |
| 0.01% | 0.01% | #163 | $85.2M | 319,412 | $52.3M | 228,675 | +90,737+39.68% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.06% | 0.04% | #109 | $81.9M | 307,203 | $51.6M | 225,441 | +81,762+36.27% | Add |
| JANE STREET GROUP, LLC |
| 0.01% | <0.01% | #192 | $75.6M | 283,341 | $17.5M | 76,400 | +206,941+270.87% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #200 | $69.5M | 260,638 | $45.4M | 198,505 | +62,133+31.30% | Add |
| Tri Locum Partners LP |
| 8.49% | 8.2% | #5 | $69.0M | 258,740 | $58.4M | 255,332 | +3,408+1.33% | Add |
| ORBIMED ADVISORS LLC |
| 1.23% | 0.82% | #29 | $65.2M | 244,456 | $41.6M | 181,977 | +62,479+34.33% | Add |
| SEI INVESTMENTS CO |
| 0.06% | 0.07% | #112 | $63.4M | 237,869 | $80.3M | 351,146 | -113,277-32.26% | Reduce |
| Pictet Asset Management Holding SA |
| 0.06% | 0.06% | #108 | $62.3M | 234,039 | $56.9M | 251,833 | -17,794-7.07% | Reduce |
| PFM Health Sciences, LP |
| 5.34% | 3.64% | #7 | $62.2M | 233,171 | $39.9M | 174,434 | +58,737+33.67% | Add |
| Frazier Life Sciences Management, L.P. |
| 1.31% | 0.78% | #27 | $60.1M | 225,155 | $30.5M | 133,333 | +91,822+68.87% | Add |
| Spyglass Capital Management LLC |
| 3.11% | 5.96% | #12 | $57.5M | 215,398 | $84.2M | 367,972 | -152,574-41.46% | Reduce |
| ARS Investment Partners, LLC |
| 2.45% | 2.49% | #18 | $56.1M | 210,462 | $47.9M | 209,456 | +1,006+0.48% | Add |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 5.72% | 2.91% | #6 | $55.0M | 206,234 | $28.5M | 124,658 | +81,576+65.44% | Add |
| NEW YORK STATE COMMON RETIREMENT FUND |
| 0.06% | 0.05% | #104 | $51.2M | 191,791 | $39.1M | 171,112 | +20,679+12.09% | Add |
| Empowered Funds, LLC |
| 0.26% | 0.07% | #58 | $49.9M | 187,271 | $11.7M | 51,135 | +136,136+266.23% | Add |
| Allspring Global Investments Holdings, LLC |
| 0.07% | 0.07% | #100 | $47.9M | 178,738 | $42.0M | 184,224 | -5,486-2.98% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.02% | 0.03% | #139 | $46.3M | 173,449 | $70.7M | 309,173 | -135,724-43.90% | Reduce |
| FRED ALGER MANAGEMENT, LLC |
| 0.15% | 0.31% | #71 | $45.7M | 171,447 | $69.7M | 304,896 | -133,449-43.77% | Reduce |
| Rock Springs Capital Management LP |
| 2.2% | 2.62% | #21 | $45.0M | 168,750 | $44.4M | 194,000 | -25,250-13.02% | Reduce |
