| ADAMS STREET PARTNERS LLC |
| 46.39% | 51.9% | #2 | $205.3M | 1.7M | $135.1M | 1.7M | 00.00% | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.01% | #62 | $121.2M | 1.0M | $58.2M | 737,518 | +272,804+36.99% | Add |
| BAILLIE GIFFORD & CO |
| 0.1% | 0.1% | #31 | $108.2M | 901,420 | $99.5M | 1.3M | -358,573-28.46% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #83 | $100.9M | 840,970 | $11.9M | 151,213 | +689,757+456.15% | Add |
| Invesco Ltd. |
| 0.01% | <0.01% | #67 | $100.3M | 835,614 | $32.1M | 406,512 | +429,102+105.56% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #102 | $95.9M | 799,468 | $14.4M | 182,463 | +617,005+338.15% | Add |
| Neuberger Berman Group LLC |
| 0.06% | 0.03% | #34 | $91.7M | 764,215 | $37.8M | 709,214 | +55,001+7.76% | Add |
| BAMCO INC /NY/ |
| 0.13% | 0.18% | #26 | $89.0M | 742,093 | $58.5M | 741,485 | +608+0.08% | Add |
| Civilization Ventures Management, LLC |
| 98.75% | 98.75% | #1 | $86.8M | 1.1M | $86.8M | 1.1M | 00.00% | Unchanged |
| WASATCH ADVISORS LP |
| 0.41% | 0.19% | #13 | $62.2M | 518,084 | $29.2M | 369,638 | +148,446+40.16% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.02% | — | #55 | $51.0M | 425,032 | $0 | 0 | +425,032 | New Buy |
| FULLER & THALER ASSET MANAGEMENT, INC. |
| 0.14% | — | #25 | $50.2M | 418,565 | $0 | 0 | +418,565 | New Buy |
| EMERALD ADVISERS, LLC |
| 1.06% | 0.6% | #7 | $45.1M | 375,858 | $18.9M | 239,562 | +136,296+56.89% | Add |
| NEXT CENTURY GROWTH INVESTORS LLC |
| 2.32% | 0.53% | #5 | $43.7M | 364,467 | $7.1M | 90,564 | +273,903+302.44% | Add |
| UBS Group AG |
| 0.01% | <0.01% | #77 | $41.3M | 344,287 | $9.6M | 121,604 | +222,683+183.12% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #97 | $41.0M | 340,371 | $19.9M | 283,140 | +57,231+20.21% | Add |
| AMERIPRISE FINANCIAL INC |
| 0.01% | <0.01% | #68 | $38.5M | 320,612 | $17.4M | 220,035 | +100,577+45.71% | Add |
| OBERWEIS ASSET MANAGEMENT INC/ |
| 0.74% | — | #10 | $35.9M | 299,030 | $0 | 0 | +299,030 | New Buy |
| WELLS FARGO & COMPANY/MN |
| 0.01% | <0.01% | #76 | $32.6M | 271,554 | $87,466 | 1,108 | +270,446+24,408.48% | Add |
| Napean Trading & Investment Co (Singapore) PTE Ltd |
| 9.62% | 7.91% | #3 | $28.0M | 233,333 | $18.4M | 233,333 | 00.00% | Unchanged |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| <0.01% | <0.01% | #79 | $26.9M | 223,933 | $19.0M | 240,587 | -16,654-6.92% | Reduce |
| EMERALD MUTUAL FUND ADVISERS TRUST |
| 0.86% | 0.51% | #9 | $24.5M | 203,990 | $10.4M | 132,206 | +71,784+54.30% | Add |
| ALLIANCEBERNSTEIN L.P. |
| 0.01% | 0.01% | #71 | $20.7M | 262,103 | $18.3M | 223,251 | +38,852+17.40% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #109 | $17.5M | 146,198 | $4.0M | 51,186 | +95,012+185.62% | Add |
| Penn Capital Management Company, LLC |
| 0.99% | 0.77% | #8 | $15.5M | 129,602 | $10.0M | 126,335 | +3,267+2.59% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.01% | <0.01% | #70 | $14.7M | 122,527 | $632 | 8 | +122,519+1,531,487.50% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #110 | $14.4M | 120,325 | $328,233 | 4,158 | +116,167+2,793.82% | Add |
| NEW YORK STATE COMMON RETIREMENT FUND |
| 0.02% | 0.01% | #52 | $14.1M | 117,771 | $7.0M | 88,682 | +29,089+32.80% | Add |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
| 0.06% | — | #35 | $14.0M | 117,063 | $0 | 0 | +117,063 | New Buy |
| BlackRock, Inc. |
| <0.01% | <0.01% | #139 | $13.7M | 114,281 | $7.5M | 95,160 | +19,121+20.09% | Add |
| FRED ALGER MANAGEMENT, LLC |
| 0.05% | — | #39 | $13.7M | 114,123 | $0 | 0 | +114,123 | New Buy |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.02% | 0.01% | #56 | $11.6M | 96,600 | $4.0M | 51,254 | +45,346+88.47% | Add |
| T. Rowe Price Investment Management, Inc. |
| 0.01% | — | #69 | $11.2M | 92,957 | $0 | 0 | +92,957 | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #120 | $10.6M | 87,934 | $7.0M | 89,114 | -1,180-1.32% | Reduce |
| PERCEPTIVE ADVISORS LLC |
| 0.16% | 0.14% | #22 | $10.4M | 86,812 | $7.2M | 91,812 | -5,000-5.45% | Reduce |
| LORD, ABBETT & CO. LLC |
| 0.03% | 0.01% | #47 | $10.4M | 86,293 | $3.5M | 44,289 | +42,004+94.84% | Add |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND |
| 0.01% | — | #57 | $10.0M | 83,300 | $0 | 0 | +83,300 | New Buy |
| HRT FINANCIAL LP |
| 0.02% | — | #53 | $9.7M | 80,709 | $0 | 0 | +80,709 | New Buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| <0.01% | <0.01% | #91 | $9.5M | 78,977 | $12.6M | 159,573 | -80,596-50.51% | Reduce |
| Greenwich Wealth Management LLC |
| 0.31% | — | #15 | $8.6M | 71,625 | $0 | 0 | +71,625 | New Buy |
| Blue Water Life Science Advisors, LP |
| 5.29% | 1.27% | #4 | $8.4M | 70,000 | $1.6M | 20,000 | +50,000+250.00% | Add |
| TD ASSET MANAGEMENT INC |
| 0.01% | <0.01% | #72 | $7.6M | 63,482 | $3.4M | 43,108 | +20,374+47.26% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #123 | $7.1M | 59,040 | $1.0M | 12,707 | +46,333+364.63% | Add |
| Verition Fund Management LLC |
| 0.01% | — | #66 | $6.8M | 57,000 | $0 | 0 | +57,000 | New Buy |
| Ensign Peak Advisors, Inc |
| 0.01% | 0.01% | #65 | $6.2M | 51,427 | $4.1M | 51,501 | -74-0.14% | Reduce |
| Jump Financial, LLC |
| 0.04% | — | #40 | $5.6M | 46,300 | $0 | 0 | +46,300 | New Buy |
| MARSHALL WACE, LLP |
| <0.01% | — | #84 | $5.4M | 44,662 | $0 | 0 | +44,662 | New Buy |
| F/m Investments LLC |
| 0.27% | 0.09% | #16 | $5.2M | 43,600 | $1.3M | 16,908 | +26,692+157.87% | Add |
| Weiss Asset Management LP |
| 0.05% | — | #36 | $5.2M | 43,057 | $0 | 0 | +43,057 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #119 | $5.2M | 42,955 | $426,276 | 5,400 | +37,555+695.46% | Add |
