| FMR LLC |
| 0.03% | 0.02% | #52 | $623.7M | 16.2M | $421.0M | 16.9M | -761,419-4.49% | Reduce |
| Deep Track Capital, LP |
| 5.24% | 4.68% | #2 | $359.9M | 9.3M | $286.3M | 11.5M | -2.2M-18.96% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #88 | $276.7M | 7.2M | $163.3M | 6.6M | +606,400+9.22% | Add |
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 1.03% | 0.22% | #17 | $223.7M | 5.8M | $38.4M | 1.5M | +4.3M+275.49% | Add |
| BAKER BROS. ADVISORS LP |
| 1.05% | 0.78% | #15 | $209.4M | 5.4M | $135.6M | 5.5M | -22,661-0.42% | Reduce |
| STATE STREET CORP |
| 0.01% | <0.01% | #80 | $177.9M | 4.6M | $112.7M | 4.5M | +79,076+1.74% | Add |
| MORGAN STANLEY |
| 0.01% | <0.01% | #66 | $174.7M | 4.5M | $31.6M | 2.0M | +2.6M+131.48% | Add |
| TCG Crossover Management, LLC |
| 4.13% | 3.17% | #5 | $171.8M | 4.5M | $110.7M | 4.5M | 00.00% | Unchanged |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | <0.01% | #75 | $150.7M | 3.9M | $92.0M | 3.7M | +205,604+5.55% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #104 | $140.2M | 3.6M | $89.9M | 3.6M | +18,631+0.51% | Add |
| JENNISON ASSOCIATES LLC |
| 0.08% | 0.05% | #36 | $127.5M | 3.3M | $79.4M | 3.2M | +113,533+3.55% | Add |
| RTW INVESTMENTS, LP |
| 1.05% | 0.79% | #16 | $122.4M | 3.2M | $78.9M | 3.2M | 00.00% | Unchanged |
| Two Seas Capital LP |
| 2.4% | 1.11% | #8 | $121.3M | 3.1M | $79.5M | 3.2M | -53,457-1.67% | Reduce |
| ARMISTICE CAPITAL, LLC |
| 1.38% | 2.41% | #11 | $113.1M | 2.9M | $135.7M | 5.5M | -2.5M-46.28% | Reduce |
| ADAR1 Capital Management, LLC |
| 4.14% | 3.92% | #4 | $89.8M | 2.3M | $66.5M | 2.7M | -348,294-13.00% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #83 | $86.1M | 2.2M | $52.0M | 2.1M | +142,500+6.81% | Add |
| T. Rowe Price Investment Management, Inc. |
| 0.06% | 0.06% | #41 | $85.6M | 2.2M | $89.7M | 3.6M | -1.4M-38.49% | Reduce |
| Woodline Partners LP |
| 0.24% | 0.19% | #25 | $76.1M | 2.0M | $49.1M | 2.0M | 00.00% | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | <0.01% | #74 | $70.5M | 1.8M | $8.4M | 339,607 | +1.5M+438.63% | Add |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #78 | $67.5M | 1.8M | $44.3M | 1.8M | -33,924-1.90% | Reduce |
| Alpine Global Management, LLC |
| 8.69% | 11.37% | #1 | $53.0M | 1.4M | $65.5M | 2.6M | -1.3M-47.86% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #87 | $52.7M | 1.4M | $30.3M | 1.2M | +150,606+12.36% | Add |
| PERCEPTIVE ADVISORS LLC |
| 0.79% | 0.78% | #19 | $52.3M | 1.4M | $39.7M | 1.6M | -240,000-15.02% | Reduce |
| D. E. Shaw & Co., Inc. |
| 0.02% | — | #56 | $47.8M | 1.2M | $0 | 0 | +1.2M | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #106 | $45.5M | 1.2M | $22.2M | 893,678 | +287,774+32.20% | Add |
| Aberdeen Group plc |
| 0.05% | 0.05% | #44 | $33.0M | 857,030 | $28.8M | 1.2M | -303,732-26.17% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #92 | $30.6M | 794,004 | $16.7M | 672,774 | +121,230+18.02% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.04% | 0.01% | #50 | $28.0M | 726,800 | $4.8M | 192,500 | +534,300+277.56% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #94 | $26.2M | 680,592 | $16.4M | 660,438 | +20,154+3.05% | Add |
| Logos Global Management LP |
| 1.1% | 1.33% | #13 | $25.6M | 665,000 | $26.7M | 1.1M | -410,000-38.14% | Reduce |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 2.48% | 1.05% | #6 | $23.9M | 619,096 | $10.3M | 414,236 | +204,860+49.45% | Add |
| Nuveen, LLC |
| 0.01% | <0.01% | #79 | $23.2M | 602,046 | $6.0M | 241,195 | +360,851+149.61% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #81 | $21.7M | 564,246 | $13.5M | 544,538 | +19,708+3.62% | Add |
| Connor, Clark & Lunn Investment Management Ltd. |
| 0.03% | 0.03% | #51 | $18.3M | 473,984 | $12.5M | 503,673 | -29,689-5.89% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #116 | $18.2M | 472,122 | $17.0M | 684,551 | -212,429-31.03% | Reduce |
| Pictet Asset Management Holding SA |
| 0.02% | 0.01% | #59 | $17.8M | 462,359 | $11.7M | 472,381 | -10,022-2.12% | Reduce |
| GROUP ONE TRADING LLC |
| 0.02% | <0.01% | #55 | $16.8M | 435,100 | $511,356 | 20,586 | +414,514+2,013.57% | Add |
| HRT FINANCIAL LP |
| 0.02% | <0.01% | #54 | $12.8M | 331,920 | $1.7M | 66,485 | +265,435+399.24% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #86 | $12.7M | 328,678 | $0 | 0 | +328,678 | New Buy |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.01% | <0.01% | #77 | $12.3M | 320,071 | $8.3M | 334,557 | -14,486-4.33% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #146 | $12.3M | 318,400 | $3.7M | 147,812 | +170,588+115.41% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #125 | $11.4M | 295,791 | $5.4M | 216,225 | +79,566+36.80% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #140 | $11.0M | 285,323 | $5.4M | 217,298 | +68,025+31.30% | Add |
| HighVista Strategies LLC |
| 2.44% | 1.54% | #7 | $10.7M | 277,873 | $5.6M | 225,139 | +52,734+23.42% | Add |
| STEMPOINT CAPITAL LP |
| 1.52% | 3.47% | #10 | $10.7M | 276,527 | $18.8M | 846,494 | -569,967-67.33% | Reduce |
| Tetragon Partners GP Ltd |
| 1.55% | 1.05% | #9 | $9.9M | 255,934 | $5.4M | 218,507 | +37,427+17.13% | Add |
| Soleus Capital Management, L.P. |
| 0.33% | 0.23% | #21 | $9.7M | 252,000 | $5.7M | 230,000 | +22,000+9.57% | Add |
| SUPERSTRING CAPITAL MANAGEMENT LP |
| 5.06% | 6.35% | #3 | $8.0M | 208,368 | $8.9M | 357,606 | -149,238-41.73% | Reduce |
| Granahan Investment Management, LLC |
| 0.28% | 0.29% | #22 | $8.0M | 206,372 | $6.1M | 244,430 | -38,058-15.57% | Reduce |
| ALGERT GLOBAL LLC |
| 0.07% | 0.04% | #38 | $6.2M | 159,840 | $2.6M | 105,770 | +54,070+51.12% | Add |
