| Catalys Pacific, LLC |
| 92.94% | 92.81% | #1 | $213.2M | 7.9M | $214.1M | 7.9M | 00.00% | Unchanged |
| RA CAPITAL MANAGEMENT, L.P. |
| 1.8% | 2.21% | #13 | $207.6M | 7.7M | $208.4M | 7.7M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #113 | $158.8M | 5.9M | $121.4M | 4.5M | +1.4M+31.36% | Add |
| Samsara BioCapital, LLC |
| 13.01% | 15.45% | #3 | $158.4M | 5.9M | $159.0M | 5.9M | 00.00% | Unchanged |
| FMR LLC |
| 0.01% | 0.01% | #90 | $121.7M | 4.5M | $131.7M | 4.9M | -349,415-7.19% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #104 | $111.7M | 4.1M | $79.5M | 2.9M | +1.2M+41.07% | Add |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 1.11% | — | #19 | $106.8M | 4.0M | $0 | 0 | +4.0M | New Buy |
| ARMISTICE CAPITAL, LLC |
| 0.92% | 0.57% | #23 | $74.9M | 2.8M | $31.9M | 1.2M | +1.6M+136.05% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #129 | $74.4M | 2.8M | $66.5M | 2.5M | +302,407+12.32% | Add |
| Laurion Capital Management LP |
| 1.73% | 2.64% | #14 | $67.6M | 2.5M | $60.5M | 2.2M | +274,112+12.28% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | <0.01% | #88 | $61.0M | 2.3M | $36.4M | 1.3M | +919,163+68.43% | Add |
| ORBIMED ADVISORS LLC |
| 1.07% | 1.1% | #20 | $56.9M | 2.1M | $55.6M | 2.1M | +57,400+2.80% | Add |
| Capital World Investors |
| 0.01% | <0.01% | #84 | $53.9M | 2.0M | $10.8M | 398,179 | +1.6M+401.69% | Add |
| Troluce Capital Advisors LLC |
| 4.94% | 1.09% | #5 | $48.0M | 1.8M | $17.7M | 655,000 | +1.1M+171.57% | Add |
| FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #79 | $44.1M | 1.6M | $48.3M | 1.8M | -149,142-8.36% | Reduce |
| Andera Partners |
| 20.8% | 24.38% | #2 | $42.9M | 1.6M | $43.1M | 1.6M | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #115 | $42.8M | 1.6M | $35.3M | 1.3M | +283,191+21.76% | Add |
| SR ONE CAPITAL MANAGEMENT, LP |
| 4.06% | 4.63% | #6 | $42.2M | 1.6M | $42.4M | 1.6M | 00.00% | Unchanged |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #110 | $40.6M | 1.5M | $29.8M | 1.1M | +405,175+36.82% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #101 | $40.3M | 1.5M | $22.2M | 818,943 | +673,633+82.26% | Add |
| SPHERA FUNDS MANAGEMENT LTD. |
| 5.18% | 5.76% | #4 | $39.7M | 1.5M | $36.3M | 1.3M | +130,000+9.70% | Add |
| Pictet Asset Management Holding SA |
| 0.04% | 0.03% | #59 | $38.6M | 1.4M | $28.0M | 1.0M | +396,211+38.30% | Add |
| Polar Capital Holdings Plc |
| 0.09% | 0.14% | #51 | $38.3M | 1.4M | $40.7M | 1.5M | -79,895-5.32% | Reduce |
| Caption Management, LLC |
| 0.18% | 0.52% | #41 | $38.0M | 1.4M | $88.7M | 3.3M | -1.9M-56.97% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #74 | $33.8M | 1.3M | $14.2M | 525,260 | +727,698+138.54% | Add |
| Ghisallo Capital Management LLC |
| 0.18% | — | #40 | $30.4M | 1.1M | $0 | 0 | +1.1M | New Buy |
| Invesco Ltd. |
| <0.01% | <0.01% | #114 | $29.4M | 1.1M | $1.1M | 42,311 | +1.0M+2,478.95% | Add |
| ALLIANCEBERNSTEIN L.P. |
| 0.01% | 0.01% | #76 | $28.9M | 1.1M | $35.4M | 975,961 | +91,580+9.38% | Add |
| Logos Global Management LP |
| 1.22% | — | #17 | $28.3M | 1.1M | $0 | 0 | +1.1M | New Buy |
| AMERICAN CENTURY COMPANIES INC |
| 0.01% | 0.01% | #73 | $28.0M | 1.0M | $24.0M | 884,107 | +152,660+17.27% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #135 | $24.7M | 917,213 | $52.2M | 1.4M | -459,785-33.39% | Reduce |
| Davern Capital Partners, LP |
| 3.95% | 3.32% | #7 | $23.2M | 858,753 | $12.1M | 447,153 | +411,600+92.05% | Add |
| Candriam S.C.A. |
| 0.1% | 0.12% | #48 | $23.1M | 857,037 | $24.6M | 678,387 | +178,650+26.33% | Add |
| Nantahala Capital Management, LLC |
| 0.74% | 0.89% | #25 | $22.1M | 820,481 | $24.3M | 895,481 | -75,000-8.38% | Reduce |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | 0.02% | #100 | $21.8M | 806,716 | $91.0M | 3.4M | -2.6M-75.98% | Reduce |
| Affinity Asset Advisors, LLC |
| 0.91% | 1.05% | #24 | $20.2M | 750,000 | $20.3M | 750,000 | 00.00% | Unchanged |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #151 | $20.2M | 747,657 | $19.1M | 706,658 | +40,999+5.80% | Add |
| TUDOR INVESTMENT CORP ET AL |
| 0.03% | 0.05% | #63 | $20.1M | 745,870 | $28.5M | 1.1M | -304,770-29.01% | Reduce |
| Aberdeen Group plc |
| 0.03% | — | #65 | $18.6M | 689,235 | $0 | 0 | +689,235 | New Buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #134 | $18.0M | 667,970 | $38.9M | 1.4M | -766,300-53.43% | Reduce |
| ALGERT GLOBAL LLC |
| 0.21% | 0.11% | #36 | $17.5M | 649,027 | $7.1M | 260,264 | +388,763+149.37% | Add |
| Catalio Capital Management, LP |
| 3.29% | 2.48% | #8 | $17.5M | 648,722 | $11.9M | 439,041 | +209,681+47.76% | Add |
| Pale Fire Capital SE |
| 1.17% | 0.87% | #18 | $16.6M | 614,284 | $9.9M | 365,626 | +248,658+68.01% | Add |
| STEMPOINT CAPITAL LP |
| 2.32% | 2.66% | #10 | $16.3M | 602,686 | $14.4M | 533,378 | +69,308+12.99% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #123 | $16.1M | 595,998 | $20.7M | 763,141 | -167,143-21.90% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #125 | $14.9M | 551,491 | $12.0M | 442,874 | +108,617+24.53% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #122 | $14.1M | 521,216 | $12.0M | 443,898 | +77,318+17.42% | Add |
| Rock Springs Capital Management LP |
| 0.64% | 0.7% | #27 | $13.1M | 484,951 | $11.9M | 439,751 | +45,200+10.28% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #116 | $12.5M | 463,387 | $3.7M | 137,433 | +325,954+237.17% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #109 | $12.2M | 450,370 | $10.2M | 375,262 | +75,108+20.01% | Add |
