| SB INVESTMENT ADVISERS (UK) LTD |
| 6.81% | 3.59% | #6 | $522.1M | 27.9M | $277.7M | 27.9M | 00.00% | Unchanged |
| FMR LLC |
| 0.02% | <0.01% | #80 | $376.3M | 20.1M | $36.8M | 3.7M | +16.4M+444.19% | Add |
| Casdin Capital, LLC |
| 15.02% | 10.86% | #1 | $300.0M | 16.0M | $143.5M | 14.4M | +1.6M+11.21% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #120 | $286.0M | 15.3M | $129.1M | 13.0M | +2.3M+17.83% | Add |
| PERCEPTIVE ADVISORS LLC |
| 3.96% | 1.9% | #9 | $263.9M | 14.1M | $97.0M | 9.8M | +4.4M+44.66% | Add |
| Commodore Capital LP |
| 13.37% | 9.79% | #2 | $224.5M | 12.0M | $169.2M | 17.0M | -5.0M-29.41% | Reduce |
| STATE STREET CORP |
| 0.01% | <0.01% | #107 | $189.5M | 10.1M | $62.0M | 6.2M | +3.9M+62.43% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #128 | $167.7M | 9.0M | $73.5M | 7.4M | +1.6M+21.35% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | <0.01% | #81 | $144.2M | 7.7M | $19.2M | 1.9M | +5.8M+300.45% | Add |
| Nextech Invest Ltd. |
| 6.04% | 3.87% | #7 | $126.8M | 6.8M | $55.0M | 5.5M | +1.3M+22.62% | Add |
| Bellevue Group AG |
| 2.44% | 1.85% | #12 | $115.7M | 6.2M | $77.6M | 7.8M | -1.6M-20.64% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #114 | $88.4M | 4.7M | $34.9M | 3.5M | +1.2M+34.64% | Add |
| TCG Crossover Management, LLC |
| 1.92% | 1.22% | #14 | $80.0M | 4.3M | $42.5M | 4.3M | 00.00% | Unchanged |
| MORGAN STANLEY |
| <0.01% | <0.01% | #125 | $72.1M | 3.9M | $9.2M | 1.8M | +2.1M+118.30% | Add |
| Siren, L.L.C. |
| 1.38% | — | #16 | $68.3M | 3.7M | $0 | 0 | +3.7M | New Buy |
| GOLDMAN SACHS GROUP INC |
| 0.01% | <0.01% | #108 | $63.8M | 3.4M | $25.3M | 2.5M | +866,840+34.10% | Add |
| WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.2% | — | #36 | $62.6M | 3.3M | $0 | 0 | +3.3M | New Buy |
| Kynam Capital Management, LP |
| 3.41% | 0.87% | #10 | $61.7M | 3.3M | $14.2M | 1.4M | +1.9M+131.70% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #88 | $58.5M | 3.1M | $29.2M | 2.9M | +187,028+6.36% | Add |
| Spruce Street Capital LP |
| 10.95% | 7.14% | #3 | $55.8M | 3.0M | $29.7M | 3.0M | 00.00% | Unchanged |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #144 | $54.1M | 2.9M | $18.5M | 1.9M | +1.0M+55.23% | Add |
| BAKER BROS. ADVISORS LP |
| 0.27% | 0.07% | #35 | $52.9M | 2.8M | $11.5M | 1.2M | +1.7M+143.66% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #132 | $50.4M | 2.7M | $19.3M | 1.9M | +757,413+39.09% | Add |
| MPM BioImpact LLC |
| 2.76% | 1.81% | #11 | $45.2M | 2.4M | $23.5M | 2.4M | +56,086+2.38% | Add |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.02% | <0.01% | #73 | $41.9M | 2.2M | $6.6M | 668,289 | +1.6M+235.02% | Add |
| ALLIANCEBERNSTEIN L.P. |
| 0.01% | <0.01% | #83 | $40.8M | 4.1M | $1.2M | 145,251 | +4.0M+2,719.67% | Add |
| Pictet Asset Management Holding SA |
| 0.04% | <0.01% | #61 | $39.2M | 2.1M | $194,940 | 19,592 | +2.1M+10,502.78% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #119 | $36.5M | 2.0M | $16.7M | 1.7M | +278,069+16.60% | Add |
| T. Rowe Price Investment Management, Inc. |
| 0.02% | — | #65 | $35.8M | 1.9M | $0 | 0 | +1.9M | New Buy |
| FRANKLIN RESOURCES INC |
| 0.01% | <0.01% | #99 | $34.7M | 1.9M | $486,704 | 48,915 | +1.8M+3,696.20% | Add |
| Polar Capital Holdings Plc |
| 0.08% | — | #43 | $33.5M | 1.8M | $0 | 0 | +1.8M | New Buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.05% | 0.04% | #57 | $32.6M | 1.7M | $25.8M | 2.6M | -850,000-32.82% | Reduce |
| Caption Management, LLC |
| 0.13% | 0.07% | #37 | $28.3M | 1.5M | $11.1M | 1.1M | +394,606+35.23% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #127 | $28.1M | 1.5M | $11.1M | 1.1M | +388,926+34.98% | Add |
| Elmind Capital, LP |
| 6.89% | 1.52% | #5 | $27.4M | 1.5M | $5.3M | 536,946 | +928,333+172.89% | Add |
| PANAGORA ASSET MANAGEMENT INC |
| 0.07% | 0.03% | #45 | $24.2M | 1.3M | $8.1M | 818,041 | +473,141+57.84% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #139 | $24.1M | 1.3M | $2.0M | 202,365 | +1.1M+536.02% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #95 | $23.9M | 1.3M | $12.8M | 1.3M | -10,559-0.82% | Reduce |
| Foresite Capital Management IV, LLC |
| 8.06% | 4.2% | #4 | $23.4M | 1.3M | $10.0M | 1.0M | +250,000+25.00% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | <0.01% | #111 | $22.9M | 1.2M | $9.0M | 900,546 | +323,460+35.92% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #142 | $20.5M | 1.1M | $5.2M | 527,611 | +567,369+107.54% | Add |
| FIRST TRUST ADVISORS LP |
| 0.01% | — | #85 | $20.1M | 1.1M | $0 | 0 | +1.1M | New Buy |
| Affinity Asset Advisors, LLC |
| 0.89% | 0.21% | #18 | $19.6M | 1.1M | $4.0M | 400,000 | +650,000+162.50% | Add |
| Frazier Life Sciences Management, L.P. |
| 0.41% | — | #28 | $19.0M | 1.0M | $0 | 0 | +1.0M | New Buy |
| Squadron Capital Management LLC |
| 5.63% | 3% | #8 | $18.1M | 970,000 | $8.2M | 822,500 | +147,500+17.93% | Add |
| Connor, Clark & Lunn Investment Management Ltd. |
| 0.03% | 0.02% | #62 | $18.0M | 961,702 | $8.3M | 837,038 | +124,664+14.89% | Add |
| Woodline Partners LP |
| 0.05% | 0.03% | #54 | $17.4M | 929,692 | $6.8M | 679,342 | +250,350+36.85% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #184 | $16.0M | 801,657 | $6.1M | 647,518 | +154,139+23.80% | Add |
| Alphabet Inc. |
| 0.36% | 0.39% | #30 | $15.6M | 1.6M | $15.6M | 1.6M | 00.00% | Unchanged |
| Timothy G. Youngquist 2020 Irrevocable Trust |
| 0.64% | — | #19 | $15.0M | 801,464 | $0 | 0 | +801,464 | New Buy |
