| MONTANOVA CAPITAL, LLC |
| 3.17% | 3.67% | #4 | $173.5M | 1.1M | $143.8M | 1.2M | -18,090-1.57% | Reduce |
| JENNISON ASSOCIATES LLC |
| 0.09% | 0.05% | #35 | $146.8M | 960,619 | $79.9M | 640,611 | +320,008+49.95% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #94 | $140.3M | 918,357 | $85.6M | 686,853 | +231,504+33.71% | Add |
| Frazier Life Sciences Management, L.P. |
| 2.94% | 2.83% | #5 | $134.8M | 882,400 | $110.0M | 882,400 | 00.00% | Unchanged |
| First Light Asset Management, LLC |
| 7.17% | 10.96% | #2 | $118.0M | 771,901 | $122.3M | 980,758 | -208,857-21.30% | Reduce |
| BVF INC/IL |
| 2.63% | 3.82% | #6 | $102.8M | 672,789 | $119.8M | 960,989 | -288,200-29.99% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #85 | $99.8M | 653,172 | $57.2M | 458,999 | +194,173+42.30% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.01% | #64 | $97.6M | 638,868 | $50.2M | 402,564 | +236,304+58.70% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #105 | $78.5M | 513,794 | $59.5M | 477,294 | +36,500+7.65% | Add |
| FRONTIER CAPITAL MANAGEMENT CO LLC |
| 0.68% | 0.48% | #18 | $73.2M | 478,833 | $46.6M | 374,035 | +104,798+28.02% | Add |
| FEDERATED HERMES, INC. |
| 0.1% | 0.09% | #34 | $66.2M | 433,015 | $54.0M | 433,015 | 00.00% | Unchanged |
| ORBIMED ADVISORS LLC |
| 0.96% | 0.46% | #12 | $50.8M | 332,360 | $23.0M | 184,600 | +147,760+80.04% | Add |
| Woodline Partners LP |
| 0.15% | 0.15% | #28 | $48.5M | 317,517 | $39.6M | 317,517 | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #92 | $42.2M | 276,164 | $25.6M | 205,609 | +70,555+34.32% | Add |
| Siren, L.L.C. |
| 0.8% | 0.89% | #16 | $39.3M | 257,485 | $32.1M | 257,485 | 00.00% | Unchanged |
| PRIMECAP MANAGEMENT CO/CA/ |
| 0.02% | 0.02% | #47 | $39.1M | 256,182 | $24.3M | 195,030 | +61,152+31.36% | Add |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 0.47% | 0.48% | #21 | $35.4M | 231,484 | $29.0M | 233,248 | -1,764-0.76% | Reduce |
| EMERALD ADVISERS, LLC |
| 0.83% | 0.64% | #14 | $35.1M | 229,486 | $20.1M | 161,500 | +67,986+42.10% | Add |
| FMR LLC |
| <0.01% | <0.01% | #112 | $32.8M | 214,841 | $26.9M | 215,808 | -967-0.45% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #90 | $32.8M | 214,597 | $24.0M | 192,908 | +21,689+11.24% | Add |
| ALLIANCEBERNSTEIN L.P. |
| 0.01% | 0.01% | #61 | $31.6M | 253,168 | $27.5M | 262,835 | -9,667-3.68% | Reduce |
| MPM BioImpact LLC |
| 1.9% | 1.99% | #9 | $31.2M | 204,027 | $25.7M | 206,404 | -2,377-1.15% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #88 | $30.8M | 201,514 | $24.2M | 194,179 | +7,335+3.78% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #111 | $27.7M | 181,428 | $8.7M | 138,505 | +42,923+30.99% | Add |
| Caption Management, LLC |
| 0.12% | 0.17% | #30 | $26.0M | 170,000 | $29.6M | 237,100 | -67,100-28.30% | Reduce |
| First Turn Management, LLC |
| 2.56% | 2.06% | #7 | $23.9M | 156,450 | $18.5M | 148,093 | +8,357+5.64% | Add |
| Bellevue Group AG |
| 0.5% | — | #20 | $23.7M | 155,000 | $0 | 0 | +155,000 | New Buy |
| EMERALD MUTUAL FUND ADVISERS TRUST |
| 0.7% | 0.64% | #17 | $19.8M | 129,847 | $13.2M | 105,820 | +24,027+22.71% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #126 | $19.7M | 128,962 | $11.3M | 90,858 | +38,104+41.94% | Add |
| Aberdeen Group plc |
| 0.03% | 0.02% | #45 | $18.4M | 120,238 | $10.1M | 81,081 | +39,157+48.29% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #101 | $14.9M | 97,193 | $8.0M | 64,371 | +32,822+50.99% | Add |
| NEXTBio Capital Management LP |
| 6.32% | 4.79% | #3 | $13.7M | 89,909 | $10.3M | 82,686 | +7,223+8.74% | Add |
| Clio Asset Management LLC |
| 10.49% | 9.48% | #1 | $13.2M | 86,343 | $11.3M | 90,757 | -4,414-4.86% | Reduce |
| Neuberger Berman Group LLC |
| 0.01% | <0.01% | #67 | $12.7M | 83,107 | $6.1M | 49,103 | +34,004+69.25% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #91 | $11.3M | 73,995 | $8.1M | 64,783 | +9,212+14.22% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #113 | $11.1M | 72,526 | $13.0M | 104,537 | -32,011-30.62% | Reduce |
| Avidity Partners Management LP |
| 1.71% | 1.77% | #10 | $10.7M | 70,000 | $8.7M | 70,000 | 00.00% | Unchanged |
| AWM Investment Company, Inc. |
| 0.92% | 0.96% | #13 | $10.6M | 69,416 | $8.7M | 69,416 | 00.00% | Unchanged |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| <0.01% | <0.01% | #99 | $10.3M | 67,469 | $8.7M | 69,901 | -2,432-3.48% | Reduce |
| SEVEN GRAND MANAGERS, LLC |
| 0.37% | 0.5% | #24 | $9.2M | 60,000 | $7.5M | 60,000 | 00.00% | Unchanged |
| Clearbridge Investments, LLC |
| 0.01% | 0.01% | #69 | $9.1M | 59,341 | $7.4M | 59,410 | -69-0.12% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #139 | $8.3M | 54,554 | $4.7M | 37,972 | +16,582+43.67% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | <0.01% | #60 | $8.1M | 53,270 | $2.2M | 17,970 | +35,300+196.44% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #87 | $8.0M | 52,212 | $11.7M | 93,646 | -41,434-44.25% | Reduce |
| Ensign Peak Advisors, Inc |
| 0.01% | 0.01% | #56 | $7.9M | 51,660 | $4.9M | 39,223 | +12,437+31.71% | Add |
| HSBC HOLDINGS PLC |
| <0.01% | — | #82 | $7.6M | 50,001 | $0 | 0 | +50,001 | New Buy |
| Nicholas Investment Partners, LP |
| 0.43% | 0.25% | #22 | $7.6M | 49,718 | $3.4M | 27,603 | +22,115+80.12% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #129 | $7.2M | 47,220 | $7.0M | 56,472 | -9,252-16.38% | Reduce |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | 0.02% | #66 | $6.8M | 44,536 | $12.1M | 96,726 | -52,190-53.96% | Reduce |
| Lisanti Capital Growth, LLC |
| 1.44% | 1.3% | #11 | $6.6M | 42,975 | $5.2M | 41,445 | +1,530+3.69% | Add |
