| T. Rowe Price Investment Management, Inc. |
| 0.45% | 0.38% | #31 | $686.6M | 30.9M | $558.1M | 30.8M | +126,486+0.41% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #102 | $275.5M | 12.4M | $212.1M | 11.7M | +704,460+6.02% | Add |
| Jupiter Topco LLC |
| 0.11% | — | #41 | $266.6M | 12.0M | $0 | 0 | +12.0M | New Buy |
| FMR LLC |
| 0.01% | 0.01% | #74 | $248.9M | 11.2M | $161.5M | 8.9M | +2.3M+25.79% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #95 | $165.6M | 7.5M | $120.6M | 6.7M | +804,517+12.09% | Add |
| Orbis Allan Gray Ltd |
| 0.53% | 0.52% | #29 | $155.6M | 7.0M | $122.6M | 6.8M | +244,311+3.61% | Add |
| Atlas Venture Life Science Advisors, LLC |
| 17.14% | 20.95% | #1 | $151.0M | 6.8M | $165.5M | 9.1M | -2.3M-25.52% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #118 | $140.2M | 6.3M | $116.1M | 6.4M | -94,100-1.47% | Reduce |
| TCG Crossover Management, LLC |
| 2.46% | 2.39% | #8 | $102.5M | 4.6M | $83.7M | 4.6M | 00.00% | Unchanged |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #103 | $89.9M | 4.0M | $75.5M | 4.2M | -113,613-2.73% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | <0.01% | #84 | $87.4M | 3.9M | $42.2M | 2.3M | +1.6M+69.08% | Add |
| FCPM III SERVICES B.V. |
| 11.39% | 11.66% | #2 | $85.5M | 3.8M | $84.2M | 4.6M | -796,130-17.14% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #100 | $83.2M | 3.7M | $63.5M | 3.5M | +239,313+6.83% | Add |
| Vestal Point Capital, LP |
| 1.75% | 2.03% | #12 | $75.0M | 3.4M | $72.5M | 4.0M | -625,000-15.63% | Reduce |
| ORBIMED ADVISORS LLC |
| 1.36% | 1.05% | #16 | $71.9M | 3.2M | $52.9M | 2.9M | +317,800+10.89% | Add |
| Frazier Life Sciences Management, L.P. |
| 1.53% | 1.47% | #14 | $70.0M | 3.2M | $57.2M | 3.2M | 00.00% | Unchanged |
| ARMISTICE CAPITAL, LLC |
| 0.84% | 1.02% | #25 | $68.6M | 3.1M | $57.6M | 3.2M | -87,884-2.77% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #104 | $67.2M | 3.2M | $55.6M | 3.3M | -101,817-3.13% | Reduce |
| PERCEPTIVE ADVISORS LLC |
| 0.9% | 1.65% | #23 | $59.7M | 2.7M | $84.6M | 4.7M | -2.0M-42.40% | Reduce |
| Logos Global Management LP |
| 2.44% | 1.27% | #9 | $56.6M | 2.6M | $25.4M | 1.4M | +1.2M+82.14% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #114 | $49.6M | 2.2M | $26.2M | 1.4M | +790,085+54.74% | Add |
| Venrock Adviser, LLC |
| 1.46% | 1.47% | #15 | $48.3M | 2.2M | $39.4M | 2.2M | 00.00% | Unchanged |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #101 | $47.9M | 2.2M | $31.2M | 1.7M | +434,079+25.19% | Add |
| Siren, L.L.C. |
| 0.96% | 1.12% | #21 | $47.3M | 2.1M | $40.4M | 2.2M | -100,000-4.49% | Reduce |
| FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #82 | $45.1M | 2.0M | $36.4M | 2.0M | +21,737+1.08% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| 0.01% | <0.01% | #87 | $43.2M | 1.9M | $17.2M | 951,589 | +994,890+104.55% | Add |
| MPM BioImpact LLC |
| 2.6% | 1.97% | #7 | $42.7M | 1.9M | $25.5M | 1.4M | +513,941+36.50% | Add |
| SAMLYN CAPITAL, LLC |
| 0.63% | 0.59% | #27 | $39.0M | 1.8M | $34.9M | 1.9M | -167,835-8.73% | Reduce |
| Sofinnova Investments, Inc. |
| 1.9% | 1.13% | #11 | $36.8M | 1.7M | $29.6M | 1.6M | +24,487+1.50% | Add |
| Palo Alto Investors LP |
| 5.35% | 4.58% | #4 | $36.6M | 1.6M | $30.0M | 1.7M | -5,451-0.33% | Reduce |
| Vivo Capital, LLC |
| 3.16% | 2.35% | #6 | $34.6M | 1.6M | $28.2M | 1.6M | 00.00% | Unchanged |
| Aberdeen Group plc |
| 0.05% | 0.04% | #55 | $34.2M | 1.5M | $25.9M | 1.4M | +109,050+7.62% | Add |
| Deep Track Capital, LP |
| 0.48% | 0.59% | #30 | $33.3M | 1.5M | $36.3M | 2.0M | -500,000-25.00% | Reduce |
| MARSHALL WACE, LLP |
| 0.03% | <0.01% | #64 | $33.1M | 1.5M | $1.5M | 83,147 | +1.4M+1,690.70% | Add |
| Polar Capital Holdings Plc |
| 0.07% | 0.09% | #49 | $28.6M | 1.3M | $24.6M | 1.4M | -72,358-5.32% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #112 | $28.4M | 1.3M | $21.7M | 1.2M | +79,243+6.61% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #107 | $26.7M | 1.2M | $21.0M | 1.2M | +43,813+3.78% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #117 | $26.4M | 1.2M | $4.4M | 240,544 | +946,914+393.66% | Add |
| Saturn V Capital Management LP |
| 3.37% | 3.17% | #5 | $23.5M | 1.1M | $17.5M | 966,609 | +90,884+9.40% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #96 | $22.0M | 988,949 | $17.2M | 947,438 | +41,511+4.38% | Add |
| Novo Holdings A/S |
| 1.24% | — | #18 | $21.3M | 960,394 | $0 | 0 | +960,394 | New Buy |
| Rock Springs Capital Management LP |
| 1.02% | 1.04% | #20 | $20.9M | 942,154 | $17.6M | 972,198 | -30,044-3.09% | Reduce |
| BRAIDWELL LP |
| 0.76% | 1.02% | #26 | $20.5M | 921,598 | $30.5M | 1.7M | -760,400-45.21% | Reduce |
| FRONTIER CAPITAL MANAGEMENT CO LLC |
| 0.18% | 0.15% | #36 | $19.4M | 874,138 | $14.9M | 821,849 | +52,289+6.36% | Add |
| BAKER BROS. ADVISORS LP |
| 0.09% | 0.08% | #44 | $18.1M | 813,449 | $14.7M | 813,449 | 00.00% | Unchanged |
| Fiera Capital Corp |
| 0.06% | 0.09% | #51 | $17.5M | 789,989 | $25.0M | 1.4M | -590,631-42.78% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #162 | $16.6M | 746,200 | $18.0M | 1.4M | -672,807-47.41% | Reduce |
| Artisan Partners Limited Partnership |
| 0.02% | 0.02% | #66 | $14.7M | 659,786 | $11.2M | 619,457 | +40,329+6.51% | Add |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #109 | $12.8M | 576,350 | $8.2M | 451,644 | +124,706+27.61% | Add |
| TD ASSET MANAGEMENT INC |
| 0.01% | 0.01% | #77 | $12.2M | 548,112 | $9.6M | 529,312 | +18,800+3.55% | Add |
